Daniel G. Lloyd

Risk of campylobacteriosis from low-throughput poultry slaughterhouses

Iulia Gherman, Victoria Cohen, Daniel G. Lloyd, Wioleta J. Trzaska et autres

Campylobacter is the most common cause of bacterial foodborne illness in the UK. Every year there are an estimated 300,000 foodborne cases in the UK, of which more than half are related to poultry meat. Campylobacter naturally lives in the guts of …

De Novo Resistance to Arg 10 -Teixobactin Occurs Slowly and Is Costly

Daniel G. Lloyd, Benjamin J. Schofield, Matthew R. Goddard, Edward James Taylor

Bacterial pathogens are rapidly evolving resistance to all clinically available antibiotics. One part of the solution to this complex issue is to better understand the resistance mechanisms to new and existing antibiotics. Here, we focus on two antibiotics. Teixobactin is a recently …

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Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA)

Ruba Malkawi, Abhishek Iyer, Anish Parmar, Daniel G. Lloyd et autres

Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) without detectable resistance. In this work, we describe the design and rapid synthesis of novel teixobactin analogues containing two …

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Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo

Anish Parmar, Rajamani Lakshminarayanan, Abhishek Iyer, Venkatesh Mayandi et autres

The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only molecule in its class that has shown in vivo antibacterial efficacy. In this work, we …

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The Myxobacterium Myxococcus xanthus Can Sense and Respond to the Quorum Signals Secreted by Potential Prey Organisms

Daniel G. Lloyd, David E. Whitworth

The myxobacterium Myxococcus xanthus is a predatory member of the soil microfauna, able to consume bacteria (Gram-negative, Gram-positive), archaea and fungi. Many potential prey of M. xanthus communicate amongst themselves using acyl homoserine lactones (AHLs) as quorum signals. M. xanthus cannot itself …

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Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of l -allo-enduracididine with its isosteres

Anish Parmar, Abhishek Iyer, Daniel G. Lloyd, Charlotte S. Vincent et autres

). We can conclude that amino acids which are the closest isosteres of l-allo-enduracididine are the key to synthesising simplified potent analogues of teixobactin using rapid syntheses and improved yields.

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Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding

Anish Parmar, Abhishek Iyer, Stephen H. Prior, Daniel G. Lloyd et autres

Leu 10 -teixobactin and Ile 10 -teixobactin have shown comparable activity to natural teixobactin.

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The Magnuson-Moss Warranty Act v. the Federal Arbitration Act: The Quintessential Chevron Case

Daniel G. Lloyd

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