Axel Steiger

An Increase in C-Reactive Protein Levels during Antidepressant Treatment as a Candidate Marker for Treatment Nonresponse in Major Depressive Disorder

Marius Solon Etzel, Yevgenia Rosenblum, Martin Dresler, Axel Steiger et autres

INTRODUCTION: One-third of patients with major depressive disorder (MDD) exhibit low-grade inflammation as reflected by C-reactive protein (CRP) concentrations >3 mg/L. We explored whether CRP changes from baseline to week one of antidepressant treatment (ΔCRP) can serve as a marker of treatment …

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Medikamente zur Behandlung von Schlaf-Wach-Störungen

Axel Steiger, Frank Weber

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An increase in C-reactive protein levels during antidepressant treatment predicts treatment non-response in major depressive disorder

Yevgenia Rosenblum, Martin Dresler, Axel Steiger, Thorsten Mikoteit et autres

Abstract Background One-third of patients with major depressive disorder (MDD) exhibit low-grade inflammation as reflected by C-reactive protein (CRP) concentrations > 3 mg/L. We explored whether CRP changes from baseline to week one of antidepressant treatment (ΔCRP) can serve as a marker …

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Sleep Neurophysiology in Depression

Yevgenia Rosenblum, Jo Anne Nakagawa, Timo van Hattem, Elena Krugliakova et autres

Sleep disturbances are both a primary symptom of and risk factor for major depressive disorder (MDD). Sleep alterations in MDD include the presence of insomnia or hypersomnia and aberrations in sleep macro- and microstructure, including a reduced latency until and prolonged duration …

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In major depression early response to antidepressant treatment in week one is associated with FKBP5-gene variants rs1360780 and rs4713916

Thorsten Mikoteit, Serena Galli, Céline K. Stäuble, Marcel Zeising et autres

Background: Major Depressive Disorder (MDD) is often associated with disinhibition of the hypothalamic-pituitary-adrenal (HPA) axis, which is regulated by negative feedback, when cortisol binds to glucocorticoid receptors (GR). GR sensitivity is reduced by the cochaperone FK506-binding protein 51 (FKBP51). Elevated FKBP51 activity …

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Electrophysiological Correlates of Lucid Dreaming: Sensor and Source Level Signatures

Çağatay Demirel, Jarrod Gott, Kristoffer Appel, Katharina Lüth et autres

Lucid dreaming (LD) is a state of conscious awareness of the ongoing oneiric state, predominantly linked to REM sleep. Progress in understanding its neurobiological basis has been hindered by small sample sizes, diverse EEG setups, and artifacts like saccadic eye movements. To …

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Fractal cycles of sleep, a new aperiodic activity-based definition of sleep cycles

Yevgenia Rosenblum, Mahdad Jafarzadeh Esfahani, Nico Adelhöfer, Paul Zerr et autres

Sleep cycles are defined as episodes of non-rapid eye movement (non-REM) sleep followed by an episode of REM sleep. Fractal or aperiodic neural activity is a well-established marker of arousal and sleep stages measured using electroencephalography. We introduce a new concept of …

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Author response: Fractal cycles of sleep, a new aperiodic activity-based definition of sleep cycles

Yevgenia Rosenblum, Mahdad Jafarzadeh Esfahani, Nico Adelhöfer, Paul Zerr et autres

This valuable study provides a novel method to detect sleep cycles based on variations in the slope of the power spectrum from electroencephalography signals.The method, dispensing with timeconsuming and potentially subjective manual identification of sleep cycles, is supported by solid evidence and …

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Neuropeptide

Axel Steiger

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Sleep Neurophysiology in Depression

Yevgenia Rosenblum, Juan Nakagawa, Timo van Hattem, Elena Krugliakova et autres

Sleep disturbances are both a primary symptom of and risk factor for major depressive disorder (MDD). Sleep alterations in MDD include the presence of insomnia or hypersomnia and aberrations in sleep macro- and microstructure, including a reduced latency until and prolonged duration …

Schlafendokrinologie – unser nächtliches Hormonorchester

Axel Steiger

Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles

Yevgenia Rosenblum, Mahdad Jafarzadeh Esfahani, Nico Adelhöfer, Paul Zerr et autres

Abstract Nocturnal human sleep consists of 4 – 6 ninety-minute cycles defined as episodes of non-rapid eye movement (non-REM) sleep followed by an episode of REM sleep. While sleep cycles are considered fundamental components of sleep, their functional significance largely remains unclear. …

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