An increase in C-reactive protein levels during antidepressant treatment predicts treatment non-response in major depressive disorder
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Le résumé fourni par la source
Abstract Background One-third of patients with major depressive disorder (MDD) exhibit low-grade inflammation as reflected by C-reactive protein (CRP) concentrations > 3 mg/L. We explored whether CRP changes from baseline to week one of antidepressant treatment (ΔCRP) can serve as a marker of treatment response. Methods CRP plasma levels were measured at baseline and after the first week of treatment in 33 MDD patients and correlated with patients’ Hamilton depression scale (HAM-D), while adjusting for age, gender and body mass index. The early and final antidepressant responses were defined as a > 25% and > 50% HAM-D score reduction at week one and four of treatment compared to baseline, respectively. We compared baseline and week-one CRP levels with the paired t-test within responders and non-responders separately and ΔCRP between the groups with the ANCOVA. Results Higher ΔCRP correlated with lower final ΔHAM-D scores (r = −0.5, p = 0.006). Non-responders showed higher ΔCRP – but not baseline and week one CRP – than responders (p = 0.018, Cohen’s d = 1.1). A ΔCRP increase was observed in 13/16 (81%) non-responders and 7/17 (41%) responders (Fisher’s exact test’s p = 0.03). A ΔCRP increase combined with an early non-response was observed in 13/16 (81%) non-responders and 1/17 (6%) responders (p < 0.0001). Conclusions Rather early ΔCRP at week one than baseline CRP might be indicative of treatment response at week four, especially if combined with early ΔHAM-D. In the future, ΔCRP could be introduced into psychiatric practice to guide treatment plans.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- An increase in C-reactive protein levels during antidepressant treatment predicts treatment non-response in major depressive disorder
- Date Crossref
- 29/08/2025
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Max Planck Institute of Psychiatry pays non établi dans la noticeStructure de recherche
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Radboud University Nijmegen pays non établi dans la noticeUniversité ou école supérieure
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Radboud University Medical Center pays non établi dans la noticeOrganisme public
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Schweizerische Ärztegesellschaft für Psycholytische Therapie pays non établi dans la noticeOrganisation à but non lucratif
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München Klinik Schwabing pays non établi dans la noticeÉtablissement de santé
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Psychiatric Services Solothurn and Faculty of Medicine of University of Basel pays non établi dans la noticeUniversité ou école supérieure
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Psychiatric and Sleep Medicine Practice Munich-Schwabing pays non établi dans la noticeInstitution
Max Planck Institute of Psychiatry, Radboud University Nijmegen et Radboud University Medical Center, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.