Zhenghao Chen

Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies

Chiara Montironi, Zhenghao Chen, Ingrid A. M. Derks, Gaspard Cretenet et autres

The tumor suppressor p53 has been described to control various aspects of metabolic reprogramming in solid tumors, but in B cell malignancies that role is as yet unknown. We generated pairs of p53 functional and knockout (KO) clones from distinct B cell …

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Important Role for Glutamine in Human and Mouse TME Models of CLL ; Towards Development of a PET Tracer As a Novel Diagnostic Tool

Helga Simon‐Molas, Chiara Montironi, Gaspard Cretenet, Sjoerd P.P. van Eeden et autres

The amino acid transporter ASCT2, encoded by the gene SLC1A5, is the main glutamine importer in proliferating human and mouse cells. We recently showed that glutamine is the main fuel of the tricarboxylic acid (TCA) cycle in cells from chronic lymphocytic leukemia …

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Electron transport chain and mTOR inhibition synergistically decrease CD40 signaling and counteract venetoclax resistance in chronic lymphocytic leukemia

Zhenghao Chen, Gaspard Cretenet, Valeria Carnazzo, Helga Simon‐Molas et autres

CD40 signaling upregulates BCL-XL and MCL-1 expression in the chronic lymphocytic leukemia (CLL) lymph node microenvironment, affording resistance to the BCL-2 inhibitor, venetoclax. Venetoclax resistance in the therapeutic setting and after long-term laboratory selection has been linked to metabolic alterations, but the …

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Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment

Zhenghao Chen, Helga Simon‐Molas, Gaspard Cretenet, Beatriz Valle‐Argos et autres

Altered metabolism is a hallmark of both cell division and cancer. Chronic lymphocytic leukemia (CLL) cells circulate between peripheral blood (PB) and lymph nodes (LNs), where they receive proliferative and prosurvival signals from surrounding cells. However, insight into the metabolism of LN …

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Targeting Metabolic Alterations in CLL Microenvironment; Inhibition of Glutamine Import Attenuates Venetoclax Resistance

Zhenghao Chen, Helga Simon‐Molas, Gaspard Cretenet, Beatriz Valle‐Argos et autres

Abstract Introduction: For chronic lymphocytic leukemia (CLL), especially in the lymph node (LN) setting where cells receive proliferative and pro-survival signals, in-depth studies of altered metabolism and its relationship with therapeutic responses are still lacking. Venetoclax, a BCL-2 inhibitor currently in wide …

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Effects of Ibrutinib on Metabolic Alterations and Micro-Environmental Signalling in Chronic Lymphocytic Leukaemia

Zhenghao Chen, Gaspard Cretenet, Beatriz Valle‐Argos, Francesco Forconi et autres

Introduction. Altered metabolism is one of the hallmarks of cancer. CLL cells circulate between peripheral blood (PB) and lymph nodes (LN) which necessitates high metabolic plasticity. In LN, CLL cells receive proliferative and pro-survival signals from surrounding cells, and become metabolically activated. …

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Electron Transport Chain Inhibition Suppresses CD40 Expression and Sensitizes Chronic Lymphocytic Leukaemia Cells to Venetoclax

Zhenghao Chen, Gaspard Cretenet, Valeria Carnazzo, Gerritje J. W. van der Windt et autres

Alterations in expression of specifically BCL-XL and MCL-1 dictate sensitivity of CLL cells to the Bcl-2 specific inhibitor venetoclax (VEN). We and others have shown upregulation of these anti-apoptotic proteins by interaction of CLL cells with CD4+ T helper cells within their …

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Linking Microenvironmental Signals to Metabolic Switches and Drug Responses in Chronic Lymphocytic Leukemia

Zhenghao Chen, Gaspard Cretenet, Hanneke ter Burg, Gabriela Andrejeva et autres

Chronic lymphocytic leukemia (CLL) has become a paradigm for a cancer that depends on signals from the microenvironment. In lymph nodes (LN), CLL cells receive from surrounding cells proliferative and pro-survival signals, which can protect against chemotherapy and also the Bcl-2 inhibitor …

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Complete genome sequence of the siphovirus Roseophage RDJLΦ 2 infecting Roseobacter denitrificans OCh114

Yantao Liang, Yongyu Zhang, Chao Zhou, Zhenghao Chen et autres

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