Yannis Pantazis

Multivalvular Involvement in Acute Heart Failure: Associations with One-Year Outcomes and the Right-Heart Phenotype

Georgios Aletras, Stylianos Fiflis, Theodora Gergopoulou, Georgia Halkiadaki et autres

Background: Valvular heart disease frequently accompanies acute heart failure (AHF), yet most studies address single valve lesions, and the prognostic weight of concurrent multivalvular involvement is less well defined. We examined the prevalence of single- and multi-valve disease and its relationship with …

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Gene duplication shaped the origin and evolution of the vertebrate olfactory combinatorial code

Iordana Zirdeli, Elias Georgoulis, Yiannis Pyrris, Yannis Pantazis et autres

Abstract Animals read their chemical environment through olfactory receptors, which form part of the class A GPCRs and are the largest gene family devoted to a single function in animals. Each odorant molecule activates a different combination of receptors, projects distinctly in …

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Two Phenotypes, One Prognosis: Period-Specific Mortality and Prediction of Post-Discharge Events in Acute Heart Failure

Georgios Aletras, Kostas Stylianou, Maria E. Marketou, M Stratinaki et autres

Background: The prognostic relevance of left ventricular ejection fraction (LVEF) categories in acute heart failure (AHF) remains debated. We compared the clinical phenotype of patients hospitalized for AHF with preserved (LVEF ≥ 50%) versus reduced (LVEF < 50%) ejection fraction (EF), and …

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Data for: Gene duplication shaped the origin and evolution of the vertebrate olfactory combinatorial code (https://doi.org/10.64898/2026.08.31.747588)

Iordana Zirdeli, Elias Georgoulis, Yiannis Pyrris, Yannis Pantazis et autres

Computed data supporting "Gene duplication shaped the origin and evolution of the vertebrate olfactory combinatorial code" (Zirdeli et al. 2026). olfactory_receptor_downstream_probabilities_v1.zip Predicted binding probability for every receptor x odorant pair, as five independent model runs and their per-pair median. Covers the ancestral …

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Data for: Gene duplication shaped the origin and evolution of the vertebrate olfactory combinatorial code (https://doi.org/10.64898/2026.08.31.747588)

Iordana Zirdeli, Elias Georgoulis, Yiannis Pyrris, Yannis Pantazis et autres

Computed data supporting "Gene duplication shaped the origin and evolution of the vertebrate olfactory combinatorial code" (Zirdeli et al. 2026). olfactory_receptor_downstream_probabilities_v1.zip Predicted binding probability for every receptor x odorant pair, as five independent model runs and their per-pair median. Covers the ancestral …

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PROFET predicts continuous gene expression dynamics from scRNA-seq data to elucidate heterogeneity of cancer treatment responses

Yu-Chen Cheng, Hyemin Gu, Thomas O. McDonald, Wenbo Wu et autres

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High-accuracy fish species identification using transfer learning on vision foundation models

Andreas Kofidis, Eleni Dretaki, Maria Zotou, Dimitris Poursanidis et autres

Citizen science initiatives play an important role in large-scale monitoring of marine biodiversity, engaging the public in ecological data collection and supporting long-term assessments of species distribution. The Mediterranean Sea, one of the most biodiverse yet heavily impacted marine ecosystems, faces growing …

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NEXT-FRET maps nonequilibrium rerouting of Escherichia coli maltose-binding protein folding by its signal peptide and chaperones

Chara Sarafoglou, Andreas Kofidis, Marijn de Boer, Mikis Mylonakis et autres

Proteins fold through dynamic intermediates that dictate their routes to functional structures, with ensembles predominantly displaying heterogeneity across nanosecond-to-microsecond timescales. Directly observing these states in solution remains challenging as single-molecule methods often require technically demanding microfluidics, surface attachment that alters behavior, or …

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Acute Kidney Injury in Acute Heart Failure Revisited: Marker of Cardiorenal Disease Severity Rather Than Isolated Renal Injury

Georgios Aletras, Maria Bachlitzanaki, M Stratinaki, Ioannis Petrakis et autres

Background: Renal function deterioration during hospitalization for acute heart failure (AHF) is common and is traditionally classified as acute kidney injury (AKI) or worsening renal function (WRF) based on changes in serum creatinine (Cr). However, Cr-based definitions may inadequately reflect the complex …

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Diuretic resistance in cardiorenal syndrome: mechanisms, monitoring and phenotype-tailored management

Georgios Aletras, Maria Bachlitzanaki, M Stratinaki, Emmanuel Foukarakis et autres

Congestion drives most hospitalizations for acute and chronic heart failure (HF), reflecting the pivotal role of sodium and water retention in disease progression. Loop diuretics remain the first-line decongestive therapy, yet up to one-third of patients exhibit an inadequate natriuretic response-defined as …

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Beyond a passing decline: acute cardiorenal syndrome as a marker of true renal dysfunction

Georgios Aletras, Maria Bachlitzanaki, M Stratinaki, A Nerantzoulis et autres

Abstract Introduction Acute cardiorenal syndrome (ACRS) is a common complication in acute heart failure (AHF) and has been linked to worse outcomes. However, some cases of worsening renal function (WRF) may reflect hemodynamic shifts rather than true kidney injury. Purpose This study …

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Transfer learning on protein language models improves antimicrobial peptide classification

Michaela Areti Zervou, Yannis Pantazis

Antimicrobial peptides (AMPs) are essential components of the innate immune system in humans and other organisms, exhibiting potent activity against a broad spectrum of pathogens. Their potential therapeutic applications, particularly in combating antibiotic resistance, have rendered AMP classification a vital task in …

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