Tetsuya Kikuchi

Automated Surveillance of Ventilator-Associated Events and Mortality Before and During the COVID-19 Pandemic: A Single-Center Retrospective Study in Japan

Junichi Yoshida, Kenichiro Shiraishi, Akiko Mataga, Tetsuya Kikuchi et autres

Purpose Using in-house automated surveillance of ventilator-associated events (VAE) from our electronic health record (EHR) system, we investigated clinical and microbiological factors associated with mortality among patients receiving mechanical ventilation (MV). Our primary objective was to identify risk factors for mortality in …

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Development of enzyme-linked immunosorbent assays for the detection of myositis-specific autoantibodies against signal recognition particle, nuclear matrix protein 2, and small ubiquitin-like modifier activating enzyme

Akihiro Murakami, Hiroki Abe, Tetsuya Kikuchi, Shunsuke Kidani et autres

OBJECTIVES: To develop and validate enzyme-linked immunosorbent assay (ELISA) systems for the detection of autoantibodies against the signal recognition particle (SRP), nuclear matrix protein 2 (NXP2), and small ubiquitin-like modifier activating enzyme (SAE). METHODS: Serum samples from 288 individuals were analysed, including …

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Remdesivir use for COVID-19 patients: Rates of serum creatinine levels to baseline or to upper limits to monitor postadministration renal function

Junichi Yoshida, Kenichiro Shiraishi, Tetsuya Kikuchi, Masao Tanaka

Abstract Objectives: The incidence of remdesivir-induced renal dysfunction has not been investigated until now. The present study explored the clinical factors and laboratory data that predict remdesivir-induced renal dysfunction. The subjects were COVID-19 patients and we determined the endpoint as dialysis or …

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A Case of Japanese Spotted Fever Misdiagnosed as COVID-19 on Admission

Kenichiro SHIRAISHI, Takahiro Noda, Sawako Hashimoto, Hiroshi Uchida et autres

COVID-19 is manifested by various symptoms and needs to be distinguished from other diseases. We report the case of a patient with Japanese spotted fever (JSF) who was admitted with a diagnosis of COVID-19. The patient was a 72-year-old woman with high …

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The obesity paradox in Japanese COVID-19 patients

Junichi Yoshida, Kaoru SETOGUCHI, Kenichiro Shiraishi, Tetsuya Kikuchi et autres

Purpose: To investigate the effect of obesity on mortality and invasive respiratory care (IRC) in patients with COVID-19. Methods:We studied 1,105 patients for 34 months and collected data.The primary outcome was all-cause death at 29 days.The secondary outcome was IRC indicated by …

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Pandemic stewardship on antimicrobials: A historical control study before and after COVID-19 care in a teaching hospital

Junichi Yoshida, Kenichiro Shiraishi, Tetsuya Kikuchi, Akiko Mataga et autres

Abstract Background: To see how the COVID-19 pandemic influenced the 3-year use of parenteral antimicrobials, we attempted a historical control study. Main body: Materials were the electronic medical record on the use of a total of 33 antimicrobials. We compared antimicrobial use …

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Sotrovimab neutralizing SARS-CoV-2: Risk factors for post-infusion clinical events

Junichi Yoshida, Kenichiro Shiraishi, Hirotaka Noda, Kazuhiro Otani et autres

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Casirivimab-imdevimab neutralizing SARS-CoV-2: post-infusion clinical events and their risk factors

Junichi Yoshida, Kenichiro Shiraishi, Tetsuro Tamura, Kazuhiro Otani et autres

Abstract Background Casirivimab-imdevimab has been developed to neutralize SARS-CoV-2. The global clinical trials in outpatients documented several adverse effects (AE), which mandate caution in Japan where part of patients return home. To investigate post-infusion clinical events and their risk factors, we attempted …

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始祖鳥を題材とした中学生向けの進化の授業方法の提案 : ぬいぐるみを利用した導入から進化の道筋を考える展開へ

貴浩 山野井, 哲也 菊地, Takahiro Yamanoi, Tetsuya Kikuchi

Interprofessional Antimicrobial Stewardship Influencing Clostridioides difficile Infection: An 8-Year Study Using Antimicrobial Use Density

Junichi Yoshida, Tetsuya Kikuchi, Takako Ueno, Akiko Mataga et autres

Purpose: To reduce Clostridioides difficile infection (CDI), we implemented interprofessional antimicrobial, infection control, and diagnostic stewardship (ipAS) conducted by physicians/pharmacists, infection control nurses, and medical technologists, respectively. As a numerical indicator for ipAS, we used antimicrobial use density (AUD) in an 8-year …

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Performance of laboratory tests for detection for Clostridioides difficile: A multicenter prospective study in Japan

Mitsutoshi Senoh, Haru Kato, Hitoshi Honda, Tadashi Fukuda et autres

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Clostridioides (Clostridium) difficile infection burden in Japan: A multicenter prospective study

Haru Kato, Mitsutoshi Senoh, Hitoshi Honda, Tadashi Fukuda et autres

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