Medical & Biological Laboratories (Japan)

A Case of Familial Chylomicronemia Syndrome Caused by a Novel Homozygous GPIHBP1 Mutation Successfully Treated with the Selective PPARα Modulator Pemafibrate

Tomoko Otsuki, Yumi Chung, Yusuke Kawachi, Shiho Komuku et autres

AIM: Familial chylomicronemia syndrome (FCS) is a rare disorder characterized by the accumulation of chylomicrons in the circulation due to genetic defects or autoantibodies affecting lipoprotein lipase (LPL), the key enzyme responsible for the metabolism of chylomicrons and very-low-density lipoproteins (VLDL), or …

au, gb, jp (code pays fourni par la source)

Concordance for myositis-specific autoantibody detection between commercial ELISA and line blot assays: a multicentre study conducted across the Asia-Pacific region

Takahisa Gono, Vidya Limaye, Latika Gupta, Vikas Agarwal et autres

OBJECTIVES: Laboratory detection of myositis-specific autoantibodies (MSAs) utilizes ELISA and multianalyte line blot assays (LBA). We sought to evaluate the concordance and reliability of these two commercial assays. METHODS: Serum samples from patients with idiopathic inflammatory myopathies (IIMs) were obtained from seven …

jp, au, gb, in, hk, cn, my, sg, th (code pays fourni par la source)

Successful long-term remission of hyperchylomicronemia caused by GPIHBP1 autoantibodies: With insights into antibody epitope effects

Ayano Tsukagoshi‐Yamaguchi, Naoya Teramoto, Suzuka Watanabe, Hiyori Kaneko et autres

jp (code pays fourni par la source)

High lipoprotein(a) results in overestimation of BQ-based low-density lipoprotein-cholesterol measurement

Azusa Yamazaki, Yuna Hakii, Masumi Ai, Shuji Miyake et autres

Most conventional low-density lipoprotein cholesterol (LDL-C) assays are standardized by the CDC reference procedure of beta-quantification (BQ) method, which involves density-based ultracentrifugation to separate very low-density lipoprotein (VLDL) and LDL. Apolipoprotein (apo) (a) covalently binds to apoB, altering lipoprotein density thereby affecting …

jp (code pays fourni par la source)

Exosome-like nanoparticles from the Okinawan medicinal plant Talinum fruticosum exhibit subset-specific bioactivities in vitro : Suppression of IL-6 production and reduction of intracellular reactive oxygen species

Yasunari Kageyama, Kazunori Namba, Yuki Akamatsu, Tomoka Ebisui et autres

Plant-derived exosome-like nanoparticles (ELNs) exhibit diverse physiological activities across biological kingdoms.Talinum fruticosum (L.) Juss., known in Okinawa as 'Shibiran', is a traditional edible medicinal plant that is considered a food-based remedy.Okinawa, one of the five globally recognized 'blue zones', is renowned for …

jp (code pays fourni par la source)

Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia

Rinako Tanaka, Jingzhu Liao, Yue Liu, Wenjun Zhu et autres

Copy number variations in the ARHGAP10 gene encoding Rho GTPase-activating protein 10 are significantly associated with schizophrenia. ARHGAP10 negatively regulates RhoA/Rho-kinase (ROCK) signaling. We previously demonstrated that fasudil, a non-selective ROCK inhibitor, exhibited antipsychotic-like effects in several mouse models of schizophrenia. ROCK …

jp (code pays fourni par la source)

Radioimmunotherapy for Malignant Mesothelioma Targeting C-ERC/Mesothelin

Hirofumi Hanaoka, Aiko Yamaguchi, Masahiro Maeda, Tatsuya Segawa et autres

Background/Objectives: Malignant mesothelioma has a poor prognosis and limited therapeutic options. C-ERC/mesothelin is highly expressed in mesotheliomas and is a potential target for radioimmunotherapy (RIT). This study evaluated the radiolabeled anti-C-ERC/mesothelin antibody mAb 22A31 as a therapeutic agent. Methods: C-ERC/mesothelin expression in …

jp, us (code pays fourni par la source)

A fully automated immunoassay for plasma kallikrein-8: Development and evaluation in mild cognitive impairment

Ishita Gupta, Masahiro Miura, Ayaka Kimura, Sayaka Tanaka et autres

jp (code pays fourni par la source)

Important relationship between hematological, biochemical findings and glycemic control in patients with diabetic type 2 in diabetic center in teaching Merjan hospital

Ragdah Hameed Jasim, Rasha Hussein Oudah, Haider Abbas Hadi Al-Mhanaa, Hiyam Faez Ahmed

Background: Type 2 diabetes mellitus (T2DM) exists as a chronic metabolic condition which involves ongoing hyperglycemia together with multiple changes in hematological and biochemical levels. HbA1c serves as the marker to determine the effectiveness of blood sugar control because it helps avoid …

iq, jp, gb, cz (code pays fourni par la source)

Development of enzyme-linked immunosorbent assays for the detection of myositis-specific autoantibodies against signal recognition particle, nuclear matrix protein 2, and small ubiquitin-like modifier activating enzyme

Akihiro Murakami, Hiroki Abe, Tetsuya Kikuchi, Shunsuke Kidani et autres

OBJECTIVES: To develop and validate enzyme-linked immunosorbent assay (ELISA) systems for the detection of autoantibodies against the signal recognition particle (SRP), nuclear matrix protein 2 (NXP2), and small ubiquitin-like modifier activating enzyme (SAE). METHODS: Serum samples from 288 individuals were analysed, including …

jp (code pays fourni par la source)

Challenges in improving the equation for estimating 24-h urinary sodium excretion from casual urine in hypertensive patients taking antihypertensive drugs: addressing overestimation, especially at low sodium excretion levels

Morio Matsumoto, Kimika Arakawa, Kai Asai, Takuya Tsuchihasi

jp (code pays fourni par la source)

Energy Harvesting Using Large Deformable Permanent Magnet

Gakuho Oe, Tomoya TSUCHIDA, Yuhiro Iwamoto, Yasushi Ido et autres

In this study, we develop a permanent magnet capable of withstanding high loads (~2 kN) and large displacements (~50% compressive deformation). This magnet can be used to develop a battery‐free Internet of Things device. To investigate the power generation mechanism, we build …

jp (code pays fourni par la source)