Betsabeh Khoramian Tusi

A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity 2258066

Kamil Slowikowski, Pritha Sen, Christopher V. Cosgriff, Jessica Tantivit et autres

Abstract Introduction The alpha-variant wave of the COVID-19 pandemic provided a unique opportunity to study, at single-cell resolution, how near-universal exposure to the same pathogen can lead to either effective or dysfunctional immune responses in humans. Methods We analyzed 2.5 million circulating …

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Generation of HLA-Compatible Hematopoietic Stem Cells from iPSCs Using a GMP-Compliant Platform for Transplantation Applications

Gurinder Singh, Qiao Lin, Aayudh Das, Zhi-Jian Liu et autres

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ST-101: Manufacturing GMP-compliant HLA-compatible definitive human hematopoietic stem and progenitors cells from iPSCs using Piezo1 agonists for clinical transplant

Gurinder Singh, Qiao Lin, Aayudh Das, Zhijian Liu et autres

Abstract Making transplantable human hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs) has been a longstanding objective of the field. Such a product would potentially provide the ability to produce unlimited numbers of HSC in vitro andeliminate the need to …

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Translational genetics identifies a phosphorylation switch in CARD9 required for innate inflammatory responses

Marta Brandt, Zhifang Cao, Chirag Krishna, Jennifer L. Reedy et autres

Population genetics continues to identify genetic variants associated with diseases of the immune system and offers a unique opportunity to discover mechanisms of immune regulation. Multiple genetic variants linked to severe fungal infections and autoimmunity are associated with caspase recruitment domain-containing protein …

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Akkermansia muciniphila phospholipid induces homeostatic immune responses

Munhyung Bae, Chelsi D. Cassilly, Xiaoxi Liu, Sung‐Moo Park et autres

Abstract Multiple studies have established associations between human gut bacteria and host physiology, but determining the molecular mechanisms underlying these associations has been challenging 1–3 . Akkermansia muciniphila has been robustly associated with positive systemic effects on host metabolism, favourable outcomes to …

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Functional analyses and single cell immunoprofiling uncover sex-specific differences in SARS-CoV2 immune memory development

Basak Eraslan, Eric Brown, Maura Benson, Liat Amir-Zilberstein et autres

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Lyme Disease, Borrelia burgdorferi, and Lipid Immunogens

Dávid Szamosvári, Munhyung Bae, Sunghee Bang, Betsabeh Khoramian Tusi et autres

High Resolution Image Download MS PowerPoint Slide The human immune system detects potentially pathogenic microbes with receptors that respond to microbial metabolites. While the overall immune signaling pathway is known in considerable detail, the initial molecular signals, the microbially produced immunogens, for …

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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

Johannes F. Scheid, Christopher O. Barnes, Basak Eraslan, Andrew Hudak et autres

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Cell Type– and Stimulation-Dependent Transcriptional Programs Regulated by Atg16L1 and Its Crohn's Disease Risk Variant T300A

Mukund Varma, Motohiko Kadoki, Ariel Lefkovith, Kara L. Conway et autres

Abstract Genome-wide association studies have identified common genetic variants impacting human diseases; however, there are indications that the functional consequences of genetic polymorphisms can be distinct depending on cell type–specific contexts, which produce divergent phenotypic outcomes. Thus, the functional impact of genetic …

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Novel FACS strategy for identification of early hematopoietic progenitors including BFU-e, CFU-e and erythroid-biased MPPs

Merav Socolovsky, Betsabeh Khoramian Tusi

We used single-cell RNA-seq and fate potential assays to develop a novel FACS strategy that identi es erythroid-biased multipotent progenitors, and erythroid committed progenitors, directly in freshly isolated mouse bone marrow.It also identi es subsets enriched for progenitors of the basophil/ mast …

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Population snapshots predict early haematopoietic and erythroid hierarchies

Betsabeh Khoramian Tusi, Samuel L. Wolock, Caleb Weinreb, Yung Hwang et autres

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Fundamental limits on dynamic inference from single-cell snapshots

Caleb Weinreb, Samuel L. Wolock, Betsabeh Khoramian Tusi, Merav Socolovsky et autres

Single-cell expression profiling reveals the molecular states of individual cells with unprecedented detail. Because these methods destroy cells in the process of analysis, they cannot measure how gene expression changes over time. However, some information on dynamics is present in the data: …

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