Nicoline M. Korthagen

Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model

Nicoline M. Korthagen, Evelyn Houtman, Irene U. Boone, Rodrigo Coutinho de Almeida et autres

OBJECTIVE: To characterize aspects of triiodothyronine (T3) induced chondrocyte terminal maturation within the molecular osteoarthritis pathophysiology using the previously established T3 human ex vivo osteochondral explant model. DESIGNS: RNA-sequencing was performed on explant cartilage obtained from OA patients (n = 8), that …

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ANTI-HYPERTROPHIC COMPOUND REVERSES DETRIMENTAL EFFECTS OF TERMINAL MATURATION IN HIGH-THROUGHPUT IN-VIVO AND EX-VIVO HUMAN OA MODELS

Ilja Boone, Nicoline M. Korthagen, Vicki van der Stap, Katryn Kampen et autres

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A Translational Model for Repeated Episodes of Joint Inflammation: Welfare, Clinical and Synovial Fluid Biomarker Assessment

Clodagh Kearney, Nicoline M. Korthagen, Saskia G. M. Plomp, Margot C. Labberté et autres

This study investigates repeated low-dose lipopolysaccharide (LPS) injections in equine joints as a model for recurrent joint inflammation and its impact on animal welfare. Joint inflammation was induced in eight horses by injecting 0.25 ng of LPS three times at two-week intervals. …

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Microencapsulated stem cells reduce cartilage damage in a material dependent manner following minimally invasive intra-articular injection in an OA rat model

Castro Johnbosco, Lisanne Karbaat, Nicoline M. Korthagen, Kelly Warmink et autres

Osteoarthritis (OA) is a degenerative disease of the joints for which no curative treatment exists. Intra-articular injection of stem cells is explored as a regenerative approach, but rapid clearance of cells from the injection site limits the therapeutic outcome. Microencapsulation of mesenchymal …

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Effects of different obesogenic diets on joint integrity, inflammation and intermediate monocyte levels in a rat groove model of osteoarthritis

Kelly Warmink, Jaqueline Lourdes Rios, Devin R. van Valkengoed, Palakkad Krishnan Unni Vinod et autres

Introduction: Obesogenic diets aggravate osteoarthritis (OA) by inducing low-grade systemic inflammation, and diet composition may affect OA severity. Here, we investigated the effect of diet on joint damage and inflammation in an OA rat model. Methods: Wistar-Han rats (n = 24) were …

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Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model

Kelly Warmink, Jaqueline Lourdes Rios, Suzy Varderidou‐Minasian, Marta Torres et autres

BACKGROUND: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient …

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Macrophage-Driven Inflammation in Metabolic Osteoarthritis: Implications for Biomarker and Therapy Development

Kelly Warmink, Prateeksha Vinod, Nicoline M. Korthagen, Harrie Weinans et autres

Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear disease, and the immune system might have …

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Mesenchymal Stem/Stromal Cells-derived extracellular vesicles as a safer therapeutic strategy in a mild metabolic osteoarthritis model

Kelly Warmink, Jaqueline Lourdes Rios, Marta Torres, Devin van Valkengoed et autres

nl, es (code pays fourni par la source)

Treatment Effects of Intra-Articular Allogenic Mesenchymal Stem Cell Secretome in an Equine Model of Joint Inflammation

Clodagh Kearney, Sohrab Khatab, Gerben M. van Buul, Saskia G. M. Plomp et autres

Background: and small animal models and warrants further investigation. Objectives: To investigate if intra-articular allogenic MSC-secretome has anti-inflammatory effects using an equine model of joint inflammation. Study Design: Randomized positively and negatively controlled experimental study. Method: In phase 1, joint inflammation was …

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Sprague Dawley Rats Show More Severe Bone Loss, Osteophytosis and Inflammation Compared toWistar Han Rats in a High-Fat, High-Sucrose Diet Model of Joint Damage

Kelly Warmink, Jaqueline Lourdes Rios, Devin R. van Valkengoed, Nicoline M. Korthagen et autres

In animal models, joint degeneration observed in response to obesogenic diet varies in nature and severity. In this study, we compare joint damage in Sprague Dawley and Wistar-Han rats in response to a high-fat, high-sucrose (HFS) diet groove model of osteoarthritis (OA). …

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RNA SEQUENCING REVEALS NOVEL MARKERS AND PATHWAYS OF T3-INDUCED CARTILAGE HYPERTROPHY

Nicoline M. Korthagen, Evelyn Houtman, Irene U. Boone, Rodrigo Coutinho de Almeida et autres

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Folate Receptor Expression by Human Monocyte–Derived Macrophage Subtypes and Effects of Corticosteroids

Kelly Warmink, M. Siebelt, Philip S. Low, Frank M. Riemers et autres

Objective Folate receptor beta (FR-β) has been used as a clinical marker and target in multiple inflammatory diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA). However, the conditions under which FR-β + macrophages arise remain unclear and could be affected by corticosteroids. …

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