Cornelius Rohde

Side-by-side evaluation of two Crimean-Congo hemorrhagic fever virus isolates in IFNAR-/-[sup] mice

Cornelius Rohde, Anke Werner, Michelle Gellhorn Serra, Petra Emmerich et autres

Identification of a pan- orthoebolavirus -reactive antibody from an rVSV-EBOV vaccinated individual

Paulina Tarnow, Hadas Cohen-Dvashi, Cornelius Rohde, Verena Kraehling et autres

Abstract Orthoebolaviruses such as Ebola virus (EBOV), Sudan virus (SUDV) and Bundibugyo virus (BDBV) can cause severe disease with high case-fatality rates. While licensed EBOV vaccines and therapeutic antibodies protect against EBOV infection, no single monoclonal antibody currently provides broad protection across …

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Side-by-side evaluation of two Crimean-Congo hemorrhagic fever virus isolates in IFNAR−/− mice

Cornelius Rohde, Anke Werner, Michelle Gellhorn Serra, Petra Emmerich et autres

Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of a severe hemorrhagic fever in humans, associated with case fatality rates up to 40%. Due to the lack of approved vaccines or specific antiviral treatments, CCHFV is classified as a biosafety …

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Lethal Sudan virus infection in IFNAR -/- mice reveals hallmarks of a cytokine storm

Michelle Gellhorn Serra, Cornelius Rohde, Lucie Sauerhering, Lars Meier et autres

Abstract Sudan virus (SUDV) is a member of the family Filoviridae , which comprises highly pathogenic viruses associated with unusually high case fatality rates. The development of medical countermeasures against filoviruses, including antivirals, vaccines, and therapeutic antibodies, requires preclinical evaluation in suitable …

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IQGAP1 and IQGAP3 are critical host factors for Marburg virus replication, nucleocapsid transport, and cell-to-cell spread

Olga Dolnik, K. Voigt, Victoria Hunszinger, Cornelius Rohde et autres

The IQGAP protein family-comprising IQGAP1, IQGAP2, and IQGAP3-exhibits structural similarity but fulfils distinct cellular functions. We previously demonstrated that IQGAP1 is recruited to Marburg virus (MARV)-induced inclusion bodies (IBs) and associates with motile nucleocapsids. To further elucidate the roles of IQGAP proteins …

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Side-by-side evaluation of two mouse models for Crimean-Congo Hemorrhagic Fever Virus infection

Cornelius Rohde, Anke Werner, Michelle Gellhorn Serra, Petra Emmerich et autres

Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of a severe hemorrhagic fever in humans, associated with case fatality rates ranging from 10 to 40%. Due to the lack of approved vaccines or specific antiviral treatments, CCHFV is classified as …

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Rapid Development of Modified Vaccinia Virus Ankara (MVA)-Based Vaccine Candidates Against Marburg Virus Suitable for Clinical Use in Humans

Alina Tscherne, Georgia Kalodimou, Alexandra Kupke, Cornelius Rohde et autres

BACKGROUND/OBJECTIVES: Marburg virus (MARV) is the etiological agent of Marburg Virus Disease (MVD), a rare but severe hemorrhagic fever disease with high case fatality rates in humans. Smaller outbreaks have frequently been reported in countries in Africa over the last few years, …

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Corrigendum to “Rescue and characterization of the first West African Marburg virus 2021 from Guinea” [Heliyon Volume 9, Issue 9, September 2023, e19613]

Isabel von Creytz, Gesche K. Gerresheim, Clemens Lier, Jana Schneider et autres

In the original published version of this article, there was a mistake made in an amino acid description in the Discussion section. Marburg virus Guinea encodes an aspartate (D) residue at amino acid position 56, not an arginine (R) residue. In the …

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The cellular protein phosphatase 2A is a crucial host factor for Marburg virus transcription

Isabel von Creytz, Cornelius Rohde, Nadine Biedenkopf

Little is known regarding the molecular mechanisms that highly pathogenic Marburg virus (MARV) utilizes to transcribe and replicate its genome. Previous studies assumed that dephosphorylation of the filoviral transcription factor VP30 supports transcription, while phosphorylated VP30 reduces transcription. Here, we focused on …

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Rescue and characterization of the first West African Marburg virus 2021 from Guinea

Isabel von Creytz, Gesche K. Gerresheim, Clemens Lier, Jana Schneider et autres

Marburg virus (MARV) is a causative agent of a severe hemorrhagic fever with high fatality rates endemic in central Africa. Current outbreaks of MARV in Equatorial Guinea and Tanzania underline the relevance of MARV as a public health emergency pathogen. In 2021, …

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Short- and Long-Interval Prime-Boost Vaccination with the Candidate Vaccines MVA-SARS-2-ST and MVA-SARS-2-S Induces Comparable Humoral and Cell-Mediated Immunity in Mice

Georgia Kalodimou, Sylvia Jany, Astrid Freudenstein, Jan Hendrik Schwarz et autres

The COVID-19 pandemic caused significant human health and economic consequences. Due to the ability of SARS-CoV-2 to spread rapidly and to cause severe disease and mortality in certain population groups, vaccines are essential for controlling the pandemic in the future. Several licensed …

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Inhibition of Rab1B Impairs Trafficking and Maturation of SARS-CoV-2 Spike Protein

Christopher Veeck, Nadine Biedenkopf, Cornelius Rohde, Stephan Becker et autres

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) utilizes cellular trafficking pathways to process its structural proteins and move them to the site of assembly. Nevertheless, the exact process of assembly and subcellular trafficking of SARS-CoV-2 proteins remains largely unknown. Here, we have identified …

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