Maja Milojković

Oxidative Phosphorylation and Fatty Acid Oxidation Are Central to Mitochondrial Metabolism Rewiring in CML Stem/Progenitor Cell Survival

Jelena Milenković, Dijana Stojanovic, Branka Djordjevic, Sanja Veličković et autres

Background/Objectives: Quiescent leukemia stem cells (LSCs) are self-renewing, pluripotent cells that present a major obstacle to the successful curative treatment of chronic myeloid leukemia (CML). LSCs function independently of BCR::ABL1 signaling and persist following tyrosine kinase inhibitor treatment. The mechanisms enabling LSC …

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Energy Metabolism at the Intersection of Signaling Networks in Chronic Myeloid Leukemia

Jelena Milenković, Dijana Stojanovic, Branka Djordjevic, Sanja Veličković et autres

Background/Objectives: Quiescent leukemia stem cells (LSCs) are self-renewing, pluripotent cells that represent a major obstacle to successful curative treatment of chronic myeloid leukemia (CML). LSCs are independent of BCR-ABL1 signaling and persist following tyrosine-kinase inhibitor treatment. The mechanisms that enable LSCs' survival …

Low Renalase Levels in Newly Diagnosed CML: Dysregulation Sensitive to Modulation by Tyrosine Kinase Inhibitors

Jelena Milenković, Dijana Stojanovic, Sanja Veličković, Branka Djordjevic et autres

Background: A dysregulated proinflammatory microenvironment is considered one of the reasons why current therapies of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKI) do not secure disease control. Therefore, the development of BCR-ABL1-independent therapies is encouraged. Renalase (RNLS) is a multifunctional …

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Indicators of stress hematopoiesis in the blood predict COVID-19 progression in patients over 65 years old

Miodrag Vučić, Jelena Milenković, Boris Djindjić, Vladana Stojiljković et autres

OBJECTIVES: Advanced age is a well-established risk factor for severe coronavirus disease 2019 (COVID-19). Exacerbated inflammation affects multiple organs, among which hematopoiesis responds by increased output of various cells. We aimed to determine the association between COVID-19 progression and large immature cell …

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The Multi-Faceted Nature of Renalase for Mitochondrial Dysfunction Improvement in Cardiac Disease

Dijana Stojanović, Miodrag Stojanović, Jelena Milenković, Aleksandra Ivana Veličkov et autres

The cellular mechanisms and signaling network that guide the cardiac disease pathophysiology are inextricably intertwined, which explains the current scarcity of effective therapy and to date remains the greatest challenge in state-of-the-art cardiovascular medicine. Accordingly, a novel concept has emerged in which …

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THE EMERGING BENEFITS OF RENALASE BASED ON PRECLINICAL STUDIES: THE CURRENT PERSPECTIVE

Dijana Stojanović, Jelena Milenković, Aleksandra Ivana Veličkov, Aleksandra Ignjatović et autres

The Mammalian Gene Collection Project enabled the discovery of a novel kidney enzyme, subsequently named renalase in 2005.Renalase was initially identified in proximal renal tubules, however the following research reveals its broad pattern of tissue expression.Evidence demonstrates its cytoprotective properties, establishing it …

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The Scientific Rationale for the Introduction of Renalase in the Concept of Cardiac Fibrosis

Dijana Stojanović, Valentina Mitić, Miodrag Stojanović, Jelena Milenković et autres

Cardiac fibrosis represents a redundant accumulation of extracellular matrix proteins, resulting from a cascade of pathophysiological events involved in an ineffective healing response, that eventually leads to heart failure. The pathophysiology of cardiac fibrosis involves various cellular effectors (neutrophils, macrophages, cardiomyocytes, fibroblasts), …

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Renalase Challenges the Oxidative Stress and Fibroproliferative Response in COVID‐19

Dijana Stojanović, Miodrag Stojanović, Jelena Milenković, Aleksandra Ivana Veličkov et autres

The hallmark of the coronavirus disease 2019 (COVID‐19) pathophysiology was reported to be an inappropriate and uncontrolled immune response, evidenced by activated macrophages, and a robust surge of proinflammatory cytokines, followed by the release of reactive oxygen species, that synergistically result in …

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The Discriminatory Ability of Renalase and Biomarkers of Cardiac Remodeling for the Prediction of Ischemia in Chronic Heart Failure Patients With the Regard to the Ejection Fraction

Dijana Stojanović, Valentina Mitić, Miodrag Stojanović, Dejan Petrović et autres

Background: Renalase has been implicated in chronic heart failure (CHF); however, nothing is known about renalase discriminatory ability and prognostic evaluation. The aims of the study were to assess whether plasma renalase may be validated as a predictor of ischemia in CHF …

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Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats

Novica Z. Bojanic, Dijana Stojanović, Maja Milojković, Boris Djindjić et autres

Introduction/Objective. Research has demonstrated the toxicant potential of aluminum, but no therapeutic options have been suggested. The aim of the study was to investigate the extent of the aluminuminduced toxicity, evaluated by hematological/biochemical disarrangements, hepcidin concentration and tissue accumulation after chronic aluminum …

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Interaction of thrombophilic SNPs in patients with unexplained infertility—multifactor dimensionality reduction (MDR) model analysis

Jelena Milenković, Maja Milojković, Dejan Mitić, Tatjana Jevtović−Stoimenov et autres

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PATHOPHYSIOLOGICAL MECHANISMS OF ALUMINIUM TOXICITY

Novica Z. Bojanic, Jelena Milenković, Dijana Stojanović, Maja Milojković et autres

Aluminium forms about 8% of the earth's crust.It is most commonly found as bauxite ore, which is used for extraction of this metal.Aluminium has a high reactivity and forms compounds such as aluminium oxide, aluminium hydroxide, and potassium aluminium sulfate.Exposure of these …

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