Yassmine Chebaro

A vitamin D‐based strategy overcomes chemoresistance in prostate cancer

Kateryna LEN-TAYON, C Béraud, Anna Y. Belorusova, Yassmine Chebaro et autres

BACKGROUND AND PURPOSE: Castration-resistant prostate cancer (CRPC) is a common male malignancy that requires new therapeutic strategies due to acquired resistance to its first-line treatment, docetaxel. The benefits of vitamin D on prostate cancer (PCa) progression have been previously reported. This study …

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Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants

Anna Y. Belorusova, Daniela Rovito, Yassmine Chebaro, Stefanie Doms et autres

The Vitamin D receptor (VDR) plays a key role in calcium homeostasis, as well as in cell proliferation and differentiation. Among the large number of VDR ligands that have been developed, we have previously shown that BXL-62 and Gemini-72, two C-20-modified vitamin …

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High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression

Juline Poirson, Irina P. Suárez, Marie‐Laure Straub, A. Cousido-Siah et autres

Persistent HPV infections can be associated with the development of several cancers. The ability to persist depends on the ability of the virus to escape the host immune system. The type I interferon (IFN) system is the first-line antiviral defense strategy. HPVs …

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A structural signature motif enlightens the origin and diversification of nuclear receptors

Brice Beinsteiner, Gabriel V. Markov, Stéphane Erb, Yassmine Chebaro et autres

Nuclear receptors are ligand-activated transcription factors that modulate gene regulatory networks from embryonic development to adult physiology and thus represent major targets for clinical interventions in many diseases. Most nuclear receptors function either as homodimers or as heterodimers. The dimerization is crucial …

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A Structural Signature Motif Enlightens the Origin and Diversification of Nuclear Receptors

Brice Beinsteiner, Gabriel V. Markov, Stéphane Erb, Yassmine Chebaro et autres

Abstract Nuclear receptors are ligand-activated transcription factors that modulate gene regulatory networks from embryonic development to adult physiology and thus represent major targets for clinical interventions in many diseases. Most nuclear receptors function either as homodimers or as heterodimers. The dimerization is …

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A multifunnel energy landscape encodes the competing α-helix and β-hairpin conformations for a designed peptide

Debayan Chakraborty, Yassmine Chebaro, David J. Wales

Depending on the amino acid sequence, as well as the local environment, some peptides have the capability to fold into multiple secondary structures. Conformational switching between such structures is a key element of protein folding and aggregation. Specifically, understanding the molecular mechanism …

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Structural Basis for DNA Gyrase Interaction with Coumermycin A1

Arnaud Vanden Broeck, Alastair G. McEwen, Yassmine Chebaro, Noëlle Potier et autres

Coumermycin A1 is a natural aminocoumarin that inhibits bacterial DNA gyrase, a member of the GHKL proteins superfamily. We report here the first cocrystal structures of gyrase B bound to coumermycin A1, revealing that one coumermycin A1 molecule traps simultaneously two ATP-binding …

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BpForms: a toolkit for concretely describing modified DNA, RNA and proteins

Paul Lang, Yassmine Chebaro, Jonathan R. Karr

Although non-canonical residues, caps, crosslinks, and nicks play an important role in the function of many DNA, RNA, proteins, and complexes, we do not fully understand how networks of non-canonical macromolecules generate behavior. One barrier is our limited formats, such as IUPAC, …

Allostery in Its Many Disguises: From Theory to Applications

Shoshana J. Wodak, Emanuele Paci, Nikolay V. Dokholyan, Igor N. Berezovsky et autres

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Modulation of RXR-DNA complex assembly by DNA context

Judit Ősz, Alastair G. McEwen, Justine Wolf, Pierre Poussin‐Courmontagne et autres

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NR3E receptors in cnidarians: A new family of steroid receptor relatives extends the possible mechanisms for ligand binding

Konstantin Khalturin, Isabelle M. L. Billas, Yassmine Chebaro, Adam M. Reitzel et autres

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Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ

Yassmine Chebaro, Serena Sirigu, Ismail Amal, Régis Lutzing et autres

Retinoic acid (RA) plays key roles in cell differentiation and growth arrest through nuclear retinoic acid receptors (RARs), which are ligand-dependent transcription factors. While the main trigger of RAR activation is the binding of RA, phosphorylation of the receptors has also emerged …

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