Lindy Berkman

Personalising radiotherapy dose in anal cancer (PLATO) Platform: 6-month patient reported outcomes across ACT3, ACT4 and ACT5 trials

Alexandra Gilbert, Chloe Gaul, Joanne Webster, Sarah Brown et autres

PURPOSE: The Personalising Radiotherapy Dose in Anal Cancer (PLATO) platform was designed to evaluate risk‑adapted dose optimisation for anal squamous cell carcinoma (ASCC). A key secondary objective was to assess the impact of tailored treatment on patient‑reported outcomes (PROs), using the EORTC …

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Early outcomes of the PLATO ACT5 randomised trial: Personalizing anal cancer radiotherapy dose.

M. Hawkins, Alexandra Gilbert, Richard Adams, Lindy Berkman et autres

1 Background: The optimal dose of radiotherapy (RT) in advanced anal squamous cell carcinoma (ASCC) is uncertain. Cure rates need to improve, but higher dose RT may result in significant morbidity. Methods: PLATO ACT5 is a seamless pilot/phII/phIII prospective, multi-centre, 3-arm RCT …

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Personalising anal cancer radiotherapy dose (PLATO): protocol for a multicentre integrated platform trial

Russell Frood, Alexandra Gilbert, Duncan Charles Gilbert, Natalie Louise Abbott et autres

INTRODUCTION: The incidence of anal carcinoma is increasing, with the current gold standard treatment being chemoradiotherapy. There is currently a wide range in the radiotherapy dose used internationally which may lead to overtreatment of early-stage disease and potential undertreatment of locally advanced …

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No Time for Waste! Co‐Producing Practice Guidelines and Research Recommendations to Promote Earlier Diagnosis of Colorectal Cancer in Community Pharmacies: A Qualitative Analysis

Dan Brunsdon, Shakira Hollyfield, Sanjana Venkat, Aradhna Kaushal et autres

INTRODUCTION: In the United Kingdom, community pharmacists (CPs) are increasingly being used to provide supplemental care for patients with specific conditions while the NHS is under pressure from declining GP numbers alongside a rising demand for services. CPs are ideally placed to …

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Standard versus reduced-dose chemoradiotherapy in anal cancer (PLATO-ACT4): short-term results of a phase 2 randomised controlled trial

Alexandra Gilbert, Richard Adams, Joanne Webster, Duncan Charles Gilbert et autres

BACKGROUND: Localised squamous cell carcinoma of the anus is treated with radical chemoradiotherapy. Cure rates are high, but treatment can result in substantial acute and long-term morbidity. We aimed to assess whether lower dose chemoradiotherapy maintains high local control rates in patients …

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3895 Long term toxicity results of ACT4 RCT: evaluating reduced dose and standard dose chemoradiotherapy in early-stage anal cancer (ISRCTN:88455282)

Alexandra Gilbert, Joanne Webster, Sarah Brown, Joanne Copeland et autres

3665 PLATO ACT 4: Long term results of an RCT evaluating reduced dose and standard dose chemoradiotherapy in early-stage anal cancer (ISRCTN:88455282)

David Sebag‐Montefiore, Mark Harrison, Alexandra Gilbert, Natalie Louise Abbott et autres

1435 De-escalating Anal Cancer Treatment (DeACT) in co-morbid and frail patients: A retrospective UK national service evaluation.

Hamish Sinclair, Michael Rowe, Vinita Ruparel, Timothy J. Mitchell et autres

Standard Versus Dose Reduced Chemoradiotherapy in Anal Cancer: Short Term Results of the PhaseII PLATO-ACT4 Randomised Controlled Trial (RCT) ISRCTN88455282

Alexandra Gilbert, Richard Adams, Webster Joanne, Duncan Charles Gilbert et autres

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Liver transplantation for isolated unresectable colorectal liver metastases - Protocol for a service evaluation in the United Kingdom - UKCoMET study

Krishna V Menon, Aarathi Vijayashanker, Jamie Murphy, Pål‐Dag Line et autres

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Aspirin as an adjuvant treatment for cancer: feasibility results from the Add-Aspirin randomised trial

Nalinie Joharatnam‐Hogan, Fay Helen Cafferty, Richard A Hubner, Daniel Swinson et autres

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Using specialist screening practitioners (SSPs) to increase uptake of bowel scope (flexible sigmoidoscopy) screening: results of a feasibility single-stage phase II randomised trial

Lesley McGregor, Hanna Skrobanski, Mary Ritchie, Lindy Berkman et autres

OBJECTIVE: To determine the feasibility of specialist screening practitioners (SSPs) offering patient navigation (PN) to facilitate uptake of bowel scope screening (BSS) among patients who do not confirm or attend their appointment. DESIGN: A single-stage phase II trial. SETTING: South Tyneside District …

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