Ianik Plante

Space Radiation Risk Assessment Project

Myung-Hee Co-Investigator: Kim, Leif Co-Investigator: Peterson, Ianik Plante, Janice Co-Investigator: Pluth et autres

Computational Model Prediction and Biological Validation using Simplified Mixed Field Exposures for the Development of a GCR Reference Field

Zarana S. Patel, Ianik Plante, Artem L. Ponomarev, Mark R. Shavers et autres

Intercomparison of low-energy electron transport calculations by different Monte Carlo track-structure simulation codes

Ioanna Kyriakou, Alexis Papadopoulos, Ioannis Polopetrakis, Christina Kotroumpelou et autres

Abstract Objective. To evaluate the uncertainty of physical features of low-energy electron transport in liquid water due to the use of different Monte Carlo track-structure (MCTS) codes. Approach. Five MCTS codes developed specifically for liquid water, namely, Geant4-DNA, PHITS-TS, RITRACKS, NASIC, and …

gr, us, jp, cn, cz, it, se, pt, fr, de (code pays fourni par la source)

CosmicDNA: A high energy extension and validation of Geant4-DNA physics models for electrons, protons and arbitrary HZE ions

Jay W. Archer, Hoang Ngoc Tran, S. Incerti, Floriane Poignant et autres

au, fr, us, jp, ch (code pays fourni par la source)

DNA decompaction enhances the formation of radiation-induced DNA double strand breaks and chromosome aberrations

Floriane Poignant, Victor Levrague, S. Incerti, Michaël Beuve et autres

Chromosome aberrations, a biomarker of space radiation-induced carcinogenesis, are a direct consequence of DNA double-strand break (DSB) misrepair and play an important role in the fate of irradiated cells. Their formation is a function of different physical and biological factors including the …

us, fr (code pays fourni par la source)

Analytical calculation of the dose to a spherical target by an ion at almost all impact parameters, and calculation of the energy deposition spectra

Ianik Plante, Floriane Poignant, Tony C. Slaba

us (code pays fourni par la source)

The long-term stability of solid-state oral pharmaceuticals exposed to simulated intravehicular space radiation

Ianik Plante, Vernie Daniels, Millennia Young, Ramona Gaza et autres

Pharmaceutical products brought for space missions must remain effective and safe throughout the mission. Previous NASA experiments suggest that radiation exposure could threaten drug stability during long-duration space missions. The Exploration Medical Capability (ExMC) Element has evaluated this possibility by exposing four …

us (code pays fourni par la source)

Effect of fluorescence in situ hybridization detection threshold on chromosome aberration counting: a simulation study

Floriane Poignant, Janice L. Huff, Stephen R. Kunkel, Ianik Plante et autres

PURPOSE: Radiation-induced carcinogenesis remains one of the main hurdles for long duration missions in deep space. The space radiation environment is diverse and includes high linear energy transfer (LET) ions that are particularly effective at inducing adverse health outcomes including cancer. Quantifying …

us (code pays fourni par la source)

Analytic and Monte Carlo calculations of dose-mean lineal energy for 1 MeV–1 GeV protons with application to radiation protection quality factor

Alexis Papadopoulos, Ioanna Kyriakou, Yusuke Matsuya, Miguel Antonio Cortés-Giraldo et autres

Abstract Radiation quality for determining biological effects is commonly linked to the microdosimetric quantity lineal energy ( $$y$$ y ) and to the dose-mean lineal energy ( $${y}_{\text{D}}$$ y D ). Calculations of $${y}_{\text{D}}$$ y D are typically performed by specialised Monte …

gr, jp, es, us, fr, de, nl (code pays fourni par la source)

Comparison of Geant4-DNA and RITRACKS/RITCARD: microdosimetry, nanodosimetry and DNA break predictions

Victor Levrague, R. Delorme, Hoang Ngoc Tran, S. Incerti et autres

This work aims at investigating the impact of DNA geometry, compaction and calculation chain on DNA break and chromosome aberration predictions for high charge and energy (HZE) ions, using the Monte Carlo codes Geant4-DNA, RITRACKS and RITCARD. To ensure consistency of ion …

fr, us (code pays fourni par la source)

Effect of Simulated Cosmic Radiation on Cytomegalovirus Reactivation and Lytic Replication

Satish Kumar Mehta, Douglass M. Diak, Sara Bustos-Lopez, Mayra A. Nelman-Gonzalez et autres

Human exploration of the solar system will expose crew members to galactic cosmic radiation (GCR), with a potential for adverse health effects. GCR particles (protons and ions) move at nearly the speed of light and easily penetrate space station walls, as well …

us (code pays fourni par la source)

Comparison of Geant4-DNA and RITRACKS/RITCARD: microdosimetry, nanodosimetry and DNA damage predictions for low to high LET ions

Floriane Poignant, Victor Levrague, Mathieu Roccia, Ngoc Hoang Tran et autres

International audience