Accès ouvert
2026
article
OpenAlex
Martha A. Q. Curley, Sue R. Beers, Lisa A. Asaro, Cheryl Burns et autres
Importance: Sedatives, commonly administered in the clinical treatment of young children with critical illness, may be harmful to early brain development. Objective: To investigate whether sedative choice during critical illness in early childhood is associated with long-term neurocognitive function. Design, Setting, and …
us
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2026
article
OpenAlex
Laura Beth Kalvas, Onella S. Dawkins-Henry, Monica Roosa Ordway, Sapna R. Kudchadkar et autres
BACKGROUND: Sleep health is an overlooked but important part of children's health and development. The health consequences associated with poor sleep health may impact recovery during critical illness. OBJECTIVE: Explore sleep health among children in the pediatric intensive care unit (PICU) receiving …
us
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Accès ouvert
2025
article
OpenAlex
Jessica Ruiz, Lisa A. Asaro, Allison S Bernique, Elizabeth Healey et autres
OBJECTIVES: Quantitative glycemic metrics are needed to identify undiagnosed celiac disease in type 1 diabetes and reduce delays in celiac diagnosis. Celiac enteropathy drives malabsorption that increases the risk of prandial insulin-glucose mismatch and hypoglycemia. We assessed if children with type 1 …
us
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Accès ouvert
2025
article
OpenAlex
Matt S. Zinter, C. Taylor, Daniela Markovic, Matteo Pellegrini et autres
Abstract Rationale Tight glycemic control (TGC) with insulin has not consistently shown benefit in critically ill patients. We previously reported that the subset of children with a hyperinflammatory subphenotype benefited from TGC in the HALF-PINT (Heart and Lung Failure – Pediatric Insulin …
us, pk, vn
(code pays fourni par la source)
2025
article
OpenAlex
Laura Beth Kalvas, Mallory Perry, Amy Cassidy, Onella S. Dawkins-Henry et autres
BACKGROUND: Adequately powered randomized controlled clinical trials (RCTs) provide the highest level of evidence to support nursing interventions that are thought to improve clinical outcomes. To ensure adequate power, recruitment at multiple study sites is often required. Complexity is exponentiated when RCTs …
us, ca
(code pays fourni par la source)
2025
article
OpenAlex
Kerri L. LaRovere, Lisa A. Asaro, Kerry Coughlin-Wells, Vinay Nadkarni et autres
OBJECTIVES: To compare two blood glucose (BG) ranges in critically ill children with and without primary neurologic diagnoses in the Heart and Lung Failure-Pediatric Insulin Titration trial (HALF-PINT; ClinicalTrials.gov Identifier NCT01565941). DESIGN: Non-prespecified post hoc analysis. SETTING: Thirty-one PICUs in the United …
us, il
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Accès ouvert
2025
article
OpenAlex
Shan L. Ward, Onella S. Dawkins-Henry, Lisa A. Asaro, David Wypij et autres
OBJECTIVES: This study aimed to investigate the impact of obesity on the use of analgesics and sedatives, rates of iatrogenic withdrawal syndrome (IWS), and outcomes in mechanically ventilated pediatric patients. Additionally, it sought to assess whether a nurse-implemented sedation protocol would be …
us, il
(code pays fourni par la source)
2024
article
OpenAlex
Martha A. Q. Curley, Laura Beth Kalvas, Mallory Perry, Lisa A. Asaro et autres
BACKGROUND: Although subject coenrollment into multiple trials is desirable, thoughtful consideration is required to avoid compromising each trial's scientific integrity. OBJECTIVE: We developed a Decision-Making Grid (GRID) to help investigators determine whether a clinical trial is compatible with a second clinical trial, …
us
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2024
conference-abstract
OpenAlex
Laura Beth Kalvas, Lisa A. Asaro, David Wypij, Martha A. Q. Curley
Aims & Objectives: Conducting multiple clinical trials simultaneously in a clinical unit may result in potential subjects being eligible for multiple trials. Though co-enrollment in multiple studies is optimal for recruitment needs, it may compromise the scientific integrity of these clinical trials. …
us
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Laura Beth Kalvas, Lisa A. Asaro, Tracy Ann Pasek, Amy Cassidy et autres
Aims & Objectives: As mortality in the pediatric intensive care unit (PICU) declines, there is growing recognition of the post-PICU morbidity experienced by survivors and their families. The Post-Intensive Care Syndrome-pediatrics (PICS-p) Longitudinal Cohort Study is currently mapping out the PICS-p trajectory …
us
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Laura Beth Kalvas, Onella S. Dawkins-Henry, Monica Roosa Ordway, Lisa A. Asaro et autres
Aims & Objectives: Sleep disruption is common in children in the pediatric intensive care unit (PICU). This prespecified secondary analysis of the RESTORE Resilience clinical trial explores associations between sleep disruption and delirium. Methods: We enrolled 54 children (6 months-17 years) with …
us
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Accès ouvert
2024
article
OpenAlex
Martha A. Q. Curley, Onella S. Dawkins-Henry, Laura Beth Kalvas, Mallory Perry et autres
OBJECTIVES: Pilot test the nurse-led chronotherapeutic bundle in critically ill children, RESTORE Resilience (R 2 ). DESIGN: A two-phase cohort study was carried out from 2017 to 2021. SETTING: Two similarly sized and organized PICUs in the United States. PATIENTS: Children 6 …
us
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