Accès ouvert
2026
article
OpenAlex
Kalil G. Abdullah, Kenji Miki, Charles K. Edgar, Shuangcheng Alivia Wu et autres
receptors and causing depolarizing currents in glioma-associated neurons with dysregulated chloride homeostasis. Depleting tumoral GAA decreased electrochemical activity, neuron-glioma interactions, and tumor aggressiveness. Our findings unveil a mechanism linking cancer metabolism with cancer neuroscience and leverage human genetics to nominate GAA synthesis …
us, es
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Karen Malacon, Kiarash Shamardani, Sophie Artandi, Lijun Ni et autres
SUMMARY Brain development, especially developmental myelination, continues through young adulthood. Concordantly, children may be particularly vulnerable to neural-immune challenges. To investigate the consequences of major childhood immune challenges, juvenile mice were exposed to respiratory influenza (H1N1) infection. White matter-specific microglial reactivity accompanied …
us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Yoon Seok Kim, Shawn Gillespie, Anna C. Geraghty, Belgin Yalçın et autres
Glioma pathophysiology is robustly regulated by interactions with neurons. Key to these interactions is the role of neuroligin-3 (NLGN3), a synaptic adhesion molecule shed in response to neuronal activity that functions as a paracrine factor crucial for glioma growth. Here we elucidate …
us, ch, de
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Richard Drexler, Belgin Yalçın, Rebecca Mancusi, Abigail Rogers et autres
Abstract High-grade gliomas are lethal brain cancers that are powerfully regulated by glutamatergic neurons through activity-dependent paracrine factors and functional neuron-to-glioma synapses. Here, we report that serotonergic neurons promote the proliferation of high-grade gliomas throughout the brain. Serotonergic neuronal activity drives circuit-specific …
us, de, fr
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Richard Drexler, Belgin Yalçın, Rebecca Mancusi, Abigail Rogers et autres
Abstract High-grade gliomas are the most aggressive form of brain tumors, and neuronal activity has emerged as a driver of glioma pathophysiology. Activity-dependent glioma growth results from paracrine factor signaling and bona fide neuron-to-glioma synapses that integrate glioma cells into brain-wide neuronal …
us, de
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Tara Barron, Belgin Yalçın, Minhui Su, Aaron Mochizuki et autres
Abstract Pediatric high-grade gliomas (HGGs) are the leading cause of brain cancer-related death in children. HGGs include distinct subtypes defined by anatomical location as well as molecular characteristics that stratify into H3K27M-altered diffuse midline gliomas (DMG) and hemispheric HGGs such as isocitrate …
us, de, fi
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Solomiia Savchuk, Kaylee M. Gentry, Wengang Wang, Elana Carleton et autres
Abstract Neural activity is increasingly recognized as a crucial regulator of cancer growth. In the brain, neuronal activity robustly influences glioma growth through paracrine mechanisms 1 and by electrochemical integration of malignant cells into neural circuitry via neuron-to-glioma synapses 2,3 . Outside …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Richard Drexler, Antonia Drinnenberg, Avishai Gavish, Belgin Yalçın et autres
Abstract Neuronal activity robustly drives the progression of diffuse midline gliomas (DMG), mediated through paracrine and synaptic neuron-to-glioma interactions. To date, research has primarily focused on glutamatergic and GABAergic neurons, while the impact of neuromodulatory neuron subpopulations and their long-range projections remain …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Shawn Gillespie, Yoon Seok Kim, Anna C. Geraghty, Belgin Yalçın et autres
Abstract Glioma pathophysiology is robustly regulated by interactions with neurons. Key to these interactions is the role of neuroligin-3 (NLGN3), a synaptic adhesion molecule shed in response to neuronal activity 1–5 that functions as a paracrine factor crucial for glioma growth. Here, …
us, de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Richard Drexler, Antonia Drinnenberg, Avishai Gavish, Belgin Yalçın et autres
Glutamatergic neuronal activity promotes proliferation of both oligodendrocyte precursor cells (OPCs) and gliomas, including diffuse midline glioma (DMG). However, the role of neuromodulatory brainstem neurons projecting to midline structures where DMGs arise remains unexplored. Here, we demonstrate that midbrain cholinergic neuronal activity …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Tara Barron, Belgin Yalçın, Minhui Su, Youkyeong Gloria Byun et autres
Abstract High-grade gliomas (HGGs) are the leading cause of brain cancer-related death. HGGs include clinically, anatomically and molecularly distinct subtypes that stratify into diffuse midline gliomas (DMGs), such as H3K27M -altered diffuse intrinsic pontine glioma, and hemispheric HGGs, such as IDH wild-type …
us, fi
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Solomiia Savchuk, Wengang Wang, Kaylee M. Gentry, Elana Carleton et autres
Abstract Neural activity is increasingly recognized as a crucial regulator of cancer growth. In the brain, neuronal activity robustly influences glioma growth both through paracrine mechanisms and through electrochemical integration of malignant cells into neural circuitry via neuron-to-glioma synapses. Outside of the …
us
(code pays fourni par la source)