Ningxin Chen

Muscle-building interventions improve glucose metabolism in elderly type 2 diabetic patients with sarcopenic obesity

Tingting Han, Xinyue Liang, Hongxia Liu, Mingyu Zhu et autres

BACKGROUND: Among all the elderly patients with type 2 diabetes mellitus (T2DM) of different body compositions, patients with sarcopenic obesity exhibited the most severe degree of insulin resistance despite possessing a normal body weight. It is well-established that interventions encompassing resistance training …

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Development and validation of a predicative model for identifying sarcopenia in Chinese adults using nutrition indicators (AHLC)

Xin Gui Zhao, Pengdong Yan, Ningxin Chen, Tingting Han et autres

Background: Sarcopenia, a condition characterized by low muscle mass, plays a critical role in the health of older adults. Early identification of individuals at risk is essential to prevent sarcopenia-related complications. This study aimed to develop a predictive model using readily available …

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Akkermansia muciniphila improve anti-PD-1 therapy against hepatocellular carcinoma by increasing host TUDCA synthesis

Xiucai Lan, Jiaming Ma, Zhipeng Huang, Ningxin Chen et autres

Abstract The immune checkpoint inhibitor PD-1mAb have shown excellent treatment in a variety of cancers including hepatocellular carcinoma (HCC), However, the patients' response rates are still low and many initial responders might become resistant to the therapy. Akkermansia muciniphila (AKK) is reported …

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Sarcopenic Obesity with Normal Body Size May Have Higher Insulin Resistance in Elderly Patients with Type 2 Diabetes Mellitus

Tingting Han, Ting Yuan, Xinyue Liang, Ningxin Chen et autres

Tingting Han, Ting Yuan, Xinyue Liang, Ningxin Chen, Jia Song, Xin Zhao, Yurong Weng, Yaomin Hu Department of Geriatrics, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People’s Republic of ChinaCorrespondence: Yaomin Hu, Department of Geriatrics, Ren Ji …

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Irisin alleviates FFA induced β-cell insulin resistance and inflammatory response through activating PI3K/AKT/FOXO1 signaling pathway

Shuang Qi Zheng, Ningxin Chen, Xing-Jian Kang, Yaomin Hu et autres

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TRB3 stimulates SIRT1 degradation and induces insulin resistance by lipotoxicity via COP1

Xingxing Ren, Ningxin Chen, Ya–Wen Chen, Wei Liu et autres

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Fenofibrate ameliorates insulin resistance in lipoprotein lipase heterozygous knockout mice and its possible mechanisms

Han Tingting, Yangxue Li, Shuang Qi Zheng, Xingxing Ren et autres

Objective To investigate the effect of fenofibrate on glucolipid metabolism and insulin sensitivity in lipoprotein lipase heterozygous knockout(LPL+ /-)mice, and to explore its mechanism. Methods LPL+ /- mice and wild type(WT)C57 mice were selected and divided into 3 groups(n=6 each group): LPL+ …

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