Katharina M. Huster

BRIDGE pilot study: a bilateral regulatory investigation of data governance and exchange

Helen X. Hou, Tom Bisson, Sophia M. Leiss, Julia Thierauf et autres

National privacy laws diverge between the European Union and United States, hindering transatlantic health data exchange and slowing AI-driven medical innovation. In response, the German Ministry of Health launched the pre-competitive Data for Health initiative, leading to the BRIDGE Pilot Study (2023-2025), …

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Intra-subject stability of different expressions of spatial QRS-T angle and their relationship to heart rate

Irena Andršová, Katerina Hnatkova, Ondřej Toman, Martina Šišáková et autres

Three-dimensional angle between the QRS complex and T wave vectors is a known powerful cardiovascular risk predictor. Nevertheless, several physiological properties of the angle are unknown or poorly understood. These include, among others, intra-subject profiles and stability of the angle relationship to …

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The Polyscore of autonomic parameters predicts mortality and identifies low-risk individuals among diabetic survivors of acute myocardial infarction

Alexander Steger, Michael Dommasch, Alexander Müller, Petra Barthel et autres

Survivors of an acute myocardial infarction with diabetes mellitus retain an increased mortality risk. Reliable assessment of individual risk is required for effective and cost-efficient medical care in these patients. The Polyscore is a previously established risk predictor consisting of seven autonomic …

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Short-Term Beat-to-Beat QT Variability Appears Influenced More Strongly by Recording Quality Than by Beat-to-Beat RR Variability

Ondřej Toman, Katerina Hnatkova, Martina Šišáková, Peter Smetana et autres

Increases in beat-to-beat variability of electrocardiographic QT interval duration have repeatedly been associated with increased risk of cardiovascular events and complications. The measurements of QT variability are frequently normalized for the underlying RR interval variability. Such normalization supports the concept of the …

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Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects

Irena Andršová, Katerina Hnatkova, Martina Šišáková, Ondřej Toman et autres

While it is now well-understood that the extent of QT interval changes due to underlying heart rate differences (i.e., the QT/RR adaptation) needs to be distinguished from the speed with which the QT interval reacts to heart rate changes (i.e., the so-called …

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Remote monitoring of COVID-19 positive high-risk patients in domestic isolation: A feasibility study

David Wurzer, Paul Spielhagen, Adonia Siegmann, Ayca Gercekcioglu et autres

BACKGROUND: If a COVID-19 patient develops a so-called severe course, he or she must be taken to hospital as soon as possible. This proves difficult in domestic isolation, as patients are not continuously monitored. The aim of our study was to establish …

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Influence of heart rate correction formulas on QTc interval stability

Irena Andršová, Katerina Hnatkova, Martina Šišáková, Ondřej Toman et autres

Monitoring of QTc interval is mandated in different clinical conditions. Nevertheless, intra-subject variability of QTc intervals reduces the clinical utility of QTc monitoring strategies. Since this variability is partly related to QT heart rate correction, 10 different heart rate corrections (Bazett, Fridericia, …

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Spatial distribution of physiologic 12-lead QRS complex

Katerina Hnatkova, Irena Andršová, Ondřej Toman, Peter Smetana et autres

The normal physiologic range of QRS complex duration spans between 80 and 125 ms with known differences between females and males which cannot be explained by the anatomical variations of heart sizes. To investigate the reasons for the sex differences as well …

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The Telecovid Study: Remote Monitoring of COVID-19 Positive High-Risk Patients in Domestic Isolation

David Wurzer, Paul Spielhagen, Adonia Siegmann, Ayca Gercekcioglu et autres

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Nocturnal respiratory rate predicts ICD benefit: A prospective, controlled, multicentre cohort study

Michael Dommasch, Alexander Steger, Petra Barthel, Katharina M. Huster et autres

Background Implantable cardioverter defibrillators (ICDs) prevent sudden cardiac death. ICD implantation decisions are currently based on reduced left ventricular ejection fraction (LVEF≤35%). However, in some patients, the non-arrhythmic death risk predominates thus diminishing ICD-therapy benefits. Based on previous observations, we tested the …

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Heart Rate Influence on the QT Variability Risk Factors

Irena Andršová, Katerina Hnatkova, Martina Šišáková, Ondřej Toman et autres

QT interval variability, mostly expressed by QT variability index (QTVi), has repeatedly been used in risk diagnostics. Physiologic correlates of QT variability expressions have been little researched especially when measured in short 10-second electrocardiograms (ECGs). This study investigated different QT variability indices, …

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Heart Rate Dependency and Inter-Lead Variability of the T Peak – T End Intervals

Irena Andršová, Katerina Hnatkova, Martina Šišáková, Ondřej Toman et autres

The electrocardiographic (ECG) assessment of the T peak–T end (Tpe) intervals has been used in many clinical studies, but several related physiological aspects have not been reported. Specifically, the sources of the Tpe differences between different ECG leads have not been systematically …

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