Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects
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Le résumé fourni par la source
While it is now well-understood that the extent of QT interval changes due to underlying heart rate differences (i.e., the QT/RR adaptation) needs to be distinguished from the speed with which the QT interval reacts to heart rate changes (i.e., the so-called QT/RR hysteresis), gaps still exist in the physiologic understanding of QT/RR hysteresis processes. This study was designed to address the questions of whether the speed of QT adaptation to heart rate changes is driven by time or by number of cardiac cycles; whether QT interval adaptation speed is the same when heart rate accelerates and decelerates; and whether the characteristics of QT/RR hysteresis are related to age and sex. The study evaluated 897,570 measurements of QT intervals together with their 5-min histories of preceding RR intervals, all recorded in 751 healthy volunteers (336 females) aged 34.3 ± 9.5 years. Three different QT/RR adaptation models were combined with exponential decay models that distinguished time-based and interval-based QT/RR hysteresis. In each subject and for each modelling combination, a best-fit combination of modelling parameters was obtained by seeking minimal regression residuals. The results showed that the response of QT/RR hysteresis appears to be driven by absolute time rather than by the number of cardiac cycles. The speed of QT/RR hysteresis was found decreasing with increasing age whilst the duration of individually rate corrected QTc interval was found increasing with increasing age. Contrary to the longer QTc intervals, QT/RR hysteresis speed was faster in females. QT/RR hysteresis differences between heart rate acceleration and deceleration were not found to be physiologically systematic (i.e., they differed among different healthy subjects), but on average, QT/RR hysteresis speed was found slower after heart rate acceleration than after rate deceleration.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects
- Date Crossref
- 07/02/2022
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Masaryk University pays non établi dans la noticeUniversité ou école supérieure
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University Hospital Brno pays non établi dans la noticeÉtablissement de santé
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Imperial College London National Heart and Lung Institute pays non établi dans la noticeUniversité ou école supérieure
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Wilhelminen Hospital pays non établi dans la noticeÉtablissement de santé
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TUM Klinikum pays non établi dans la noticeÉtablissement de santé
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Technical University of Munich pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Wilhelminenspital der Stadt Wien pays non établi dans la noticeInstitution
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Klinikum rechts der Isar pays non établi dans la noticeInstitution
Masaryk University, University Hospital Brno et National Heart and Lung Institute — Imperial College London, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.