Eftychia Bellou

Life stage shifts in salivary microbiota determinants: a cross-sectional study in twins

Simon Haworth, Eftychia Bellou, Ralf Kuja‐Halkola, Wai Lok Yau et autres

Both host genetics and environmental exposures shape the salivary microbiota; however, the relative contributions of these factors from early life to adulthood remain unclear. To address this, we profiled the salivary microbiota of 3387 twin pairs: 939 infant pairs (9-12 months) and …

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Patient reported outcome measures of head and neck cancer patients treated with curative intent radiotherapy within the Head and Neck 5000 cohort

Siona Growcott, Todd Dembrey, Yasmin Odding, Eftychia Bellou et autres

The AddORN Project: Spatial relationships between dental extractions, maximum mandibular dose and osteoradionecrosis.

Sarah Hargreaves, Eftychia Bellou, Rachel Brooker, Emma De Winton et autres

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Benchmarking Alzheimer’s disease prediction: personalised risk assessment using polygenic risk scores across various methodologies and genome-wide studies

Eftychia Bellou, Woori Kim, Ganna Leonenko, Feifei Tao et autres

BACKGROUND: The success of selecting high risk or early-stage Alzheimer's disease individuals for the delivery of clinical trials depends on the design and the appropriate recruitment of participants. Polygenic risk scores (PRS) show potential for identifying individuals at risk for Alzheimer's disease …

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Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks

Andrew Graham, Eftychia Bellou, Janet Harwood, Ümran Yaman et autres

Ageing underlies functional decline of the brain and is the primary risk factor for several neurodegenerative conditions, including Alzheimer's disease (AD). However, the molecular mechanisms that cause functional decline of the brain during ageing, and how these contribute to AD pathogenesis, are …

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Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer’s disease in a European population

Emily Simmonds, Ganna Leonenko, Ümran Yaman, Eftychia Bellou et autres

Although there are several genome-wide association studies available which highlight genetic variants associated with Alzheimer's disease (AD), often the X chromosome is excluded from the analysis. We conducted an X-chromosome-wide association study (XWAS) in three independent studies with a pathologically confirmed phenotype …

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Genetic variation associated with human longevity and Alzheimer’s disease risk act through microglia and oligodendrocyte cross-talk

Andrew Graham, Eftychia Bellou, Janet Harwood, Ümran Yaman et autres

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Genetic variation associated with human longevity and Alzheimer's disease risk act through microglia and oligodendrocyte cross-talk

Andrew Graham, Eftychia Bellou, Janet Harwood, Ümran Yaman et autres

Ageing is the greatest global healthcare challenge, as it underlies age-related functional decline and is the primary risk factor for a range of common diseases, including neurodegenerative conditions such as Alzheimer's disease (AD). However, the molecular mechanisms defining chronological age versus biological …

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Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas, Sonia Moreno–Grau, Niccoló Tesi, Benjamin Grenier‐Boley et autres

The original version of this Article omitted from the author list the 212th author Patrizia Mecocci, who is from the Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. Consequently, the “Sample Contribution” section of Author Contributions was …

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Are Alzheimer's and coronary artery diseases genetically related to longevity?

Eftychia Bellou, Valentina Escott‐Price

Introduction In the last decade researchers have attempted to investigate the shared genetic architecture of longevity and age-related diseases and assess whether the increased longevity in certain people is due to protective alleles in the risk genes for a particular condition or …

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Blood plasma biomarkers improve prediction accuracy over and above genetic predictors of Alzheimer’s disease

Joshua Stevenson‐Hoare, Amanda Heslegrave, Ganna Leonenko, Dina Fathalla et autres

Abstract Background Prediction models of Alzheimer’s disease using genetic information, such as polygenic risk scores, have been able to reach high levels of prediction accuracy. However, since confirmation of the disease is only possible post‐mortem, these levels of prediction accuracy are typically …

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Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization

Sizheng Steven Zhao, Eftychia Bellou, Suzanne Verstappen, Michael J. Cook et autres

OBJECTIVES: To examine associations between PsA and psoriasis vs lifestyle factors and comorbidities by triangulating observational and genetic evidence. METHODS: We analysed cross-sectional data from the UK Biobank (1836 PsA, 8995 psoriasis, 36 000 controls) to describe the association between psoriatic disease …

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