Upasana Mehra

Structural characterization of the HDV virion and its ribonucleoprotein

Samuel Itskanov, Beatrice E. Ary, Upasana Mehra, Irene Lew et autres

Hepatitis D virus (HDV) is a small RNA satellite virus of hepatitis B virus (HBV) which encodes a single protein, HDV delta antigen (HDAg), that is required for replication. Viral replication occurs independently from HBV and relies primarily on host RNA polymerase(s). …

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Insights into Mtg3-mitochondrial ribosome association in Saccharomyces cerevisiae

Ritika Kapila, Upasana Mehra, Jaswinder Kaur, Yash Verma et autres

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Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection

Dara L. Burdette, Anastasia Hyrina, Zhijuan Song, Rudolf K. F. Beran et autres

The standard of care for the treatment of chronic hepatitis B (CHB) is typically lifelong treatment with nucleos(t)ide analogs (NAs), which suppress viral replication and provide long-term clinical benefits. However, infectious virus can still be detected in patients who are virally suppressed …

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MRX8, the conserved mitochondrial YihA GTPase family member, is required for de novo Cox1 synthesis at suboptimal temperatures in Saccharomyces cerevisiae

Yash Verma, Upasana Mehra, Dharmendra Kumar Pandey, Joy Kar et autres

The role of the novel protein Mrx8, a putative GTPase essential for optimal Cox1 translation under cold stress, is reported. Additionally, GTPBP8, the human orthologue, rescues cellular respiration in Δ cells and localizes to the mitochondria in mammalian cells, indicating a universal …

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Hepatitis B Virus X Protein Function Requires Zinc Binding

Dhivya Ramakrishnan, Weimei Xing, Rudolf K. F. Beran, Saketh Chemuru et autres

The structural maintenance of chromosomes 5/6 complex (Smc5/6) is a host restriction factor that suppresses HBV transcription. HBV counters this restriction by expressing HBV X protein (HBx), which redirects a host ubiquitin ligase to target Smc5/6 for degradation. Despite this recent advance …

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A YEAST SPECIFIC INSERTION AMIDST OBG FOLD IS CRITICAL FOR THE MITOCHONDRIAL FUNCTION OF M tg 2 p IN SACCHAROMYCES CEREVISIAE

Upasana Mehra, Jaswinder Kaur, Dharmendra Kumar Pandey, Kaustuv Datta

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High-Throughput Screening of Formulations to Optimize the Thermal Stability of a Therapeutic Monoclonal Antibody

Anita Niedziela‐Majka, Elaine Kan, Perry Weissburg, Upasana Mehra et autres

Monoclonal antibodies (mAbs) are an important class of biotherapeutics. Successful development of a mAb depends not only on its biological activity but also on its physicochemical properties, such as homogeneity and stability. mAb stability is affected by its formulation. Among the many …

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Abstract LB-121: Dissecting MAPK pathway in BRAFmut melanoma: Intricacies of ERK1 and ERK2

Tatiana Zavorotinskaya, Upasana Mehra, Yumin Dai, Michel P. Faure et autres

Abstract The MAPK signaling cascade, comprised of the RAS GTPases, the RAF, MEK1/2 and ERK1/2 kinases is frequently deregulated in cancer. ERK1 and ERK2 transmit signals generated by mutant BRAF, Ras or by activated receptor tyrosine kinases to a wide range of …

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1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

Sampath‐Kumar Anandan, Heather Kay Webb, Dawn Chen, Yixin Wang et autres

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Inhibition of Soluble Epoxide Hydrolase Attenuated Atherosclerosis, Abdominal Aortic Aneurysm Formation, and Dyslipidemia

Le-Ning Zhang, Jon Vincelette, Ying Cheng, Upasana Mehra et autres

OBJECTIVE: Epoxyeicosatrienoic acids (EETs) have been shown to have antiinflammatory effects and therefore may play a role in preventing vascular inflammatory and atherosclerotic diseases. Soluble epoxide hydrolase (s-EH) converts EETs into less bioactive dihydroxyeicosatrienoic acids. Thus, inhibition of s-EH can prevent degradation …

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Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation and dyslipidemia in apolipoprotein E deficient mice infused with angiotensin II

Lening Zhang, Jon Vincelette, Ying Cheng, Upasana Mehra et autres

Objective‐Epoxyeicosatrienoic acids (EETs) have been shown to have anti‐inflammatory effects. So they may play a role in preventing vascular inflammatory and atherosclerotic diseases. Soluble epoxide hydrolase (s‐EH) converts EETs into less bioactive dihydroxyeicosatrienoic acids. Thus, inhibition of s‐EH can prevent degradation of …

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Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

Dean R. Artis, Jack J. Lin, Chao Zhang, Weiru Wang et autres

In a search for more effective anti-diabetic treatment, we used a process coupling low-affinity biochemical screening with high-throughput co-crystallography in the design of a series of compounds that selectively modulate the activities of all three peroxisome proliferator-activated receptors (PPARs), PPARalpha, PPARgamma, and …

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