Marc D. Beyer

A single-cell transcriptional reference for the functional and developmental diversity of neonatal innate lymphoid cells

Sabrina Bianca Bennstein, Julian Reiß, Katharina Raba, Thi X.U. Pham et autres

Circulating innate lymphoid cells (cILCs) comprise a complex mixture of subsets with effector functions and progenitor potential toward mature ILCs and natural killer (NK) cells. Here, we dissected cord blood (CB) cILC complexity using single-cell RNA sequencing (RNA-seq) combined with developmental and …

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A reproducible human brain tissue model to study physiological and disease-associated microglia phenotypes

Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, Stephan A. Müller et autres

Abstract Stem-cell-based in vitro models offer promising potential to elucidate human brain cell functions and interactions under physiological and pathological conditions. However, harnessing this potential is impaired by low reproducibility, maturity, or cell-type diversity of existing models. Especially, prolonged incorporation of mature …

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Laser-Capture Microdissection Followed by ATAC-Seq

Celia L. Hartmann, Joachim L. Schultze, Marc D. Beyer, Caterina Carraro

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Kupffer cells control neonatal hepatic metabolism via Igf1 signaling

Nikola Makdissi, DORIS J. HIRSCHMANN, A. N. FROLOV, Inaam Sado et autres

During perinatal development, liver metabolism is tightly regulated to ensure energy supply for the newborn. Before birth, glycogen is stored in hepatocytes and later metabolized to glucose, meeting neonatal energy demands. Shortly after birth, lipogenesis begins, driven by transcriptional activation of enzymes …

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Microbial translocation in liver fibrosis induces chronic IFNAR signaling that directly affects innate immune responses to systemic bacterial infection

Z Abdullah, P Hackstein, J Trebicka, Marc D. Beyer et autres

A common clinical complication in patients with liver fibrosis or cirrhosis is exacerbations of bacterial infections, which often persist in these patients. In order to study the underlying pathophysiological cellular and molecular mechanisms in mice, we investigated the immune responses to Listeria …

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