G T Pickering

Genetic Variability Determines Cardiometabolic Response to Orange Juice and Hesperidin Intake

Dragan Milenković, Caroline Gilcher, Nicolas Macian, Christine Morand et autres

Objectives: Several clinical studies have suggested that intake of orange juice and/or hesperidin has a positive effect on health outcomes. However, large interindividual variability in response has been described, which could be attributed to different factors, including genetic polymorphisms described in one …

us, de, fr, mk (code pays fourni par la source)

Multidimensional phenotyping towards personalized preventive nutritional support for older adults, protocol for an open trial in >100 subjects

Laurent Mosoni, Cécile Gladine, Marie-Anne Verny, Jérémie David et autres

Introduction: Inter-individual variability in response to food is higher than originally thought. This variability may increase with age and lower the efficiency of general dietary guidelines. Thus, following the lead of pioneering studies in adults, our aim is to characterize interindividual variability …

Postmenopausal Osteoporosis, Endothelial Dysfunction, and Cardiovascular Risk

Marie‐Eva Pickering, Christian Heiss, Véronique Morel, G T Pickering et autres

BACKGROUND/OBJECTIVES: Bone and cardiovascular health are interconnected, yet their relationship with endothelial function in postmenopausal osteoporosis remains insufficiently understood. This study aimed to investigate, in women with osteoporosis, the associations between endothelial function, assessed by flow-mediated dilation (FMD), bone turnover, and cardiovascular …

fr, gb, us (code pays fourni par la source)

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

Nicolas Macian, Christian Dualé, M. DeLay, Vincent Leray et autres

BACKGROUND: Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway. …

fr, ch, us (code pays fourni par la source)

Increasing plant protein sources in the diet modulates gut microbiota and tryptophan metabolism in men at cardiometabolic risk

Gaïa Lépine, Anne-Marie Davila, Gwendal Cueff, G T Pickering et autres

). Compared to CON, FLEX increased fecal xanthurenic acid and decreased the genetic potential for indole production. Combined with previously reported plasma changes (increased indole propionic acid and decreased indoxyl sulfate after FLEX), these findings suggest a shift away from indole production …

fr, in (code pays fourni par la source)

Bioavailable human metabolites of a keratin-derived hydrolysate promote primary human dermal fibroblast activities and protect against oxidative stress-related damages

Fabien Wauquier, Line Boutin-Wittrant, Jean‐Philippe Soulard, Régine Minet Quinard et autres

Introduction: Nutricosmetic strategies may support skin homeostasis by modulating dermal fibroblast function. Poultry feather keratin hydrolysates are a sustainable source of amino acids and low-molecular weight peptides. We investigated whether bioavailable human metabolites generated after ingestion of a keratin-derived hydrolysate (Kera‑Diet®) influence …

pl, fr (code pays fourni par la source)

Quantitative sensory testing of pain in osteoporosis: a pilot randomized clinical trial with magnesium supplementation

Marie‐Eva Pickering, Véronique Morel, Macian Nicolas, Christian Dualé et autres

BACKGROUND: Bisphosphonates (BP) are a recommended treatment for osteoporosis and an analgesic effect has been suggested. Magnesium is involved in pain mechanisms, mood disorders and also in bone homeostasis. Association of BPs and magnesium has however not been studied to explore pain …

fr, dk (code pays fourni par la source)

Orange juice and hesperidin increase flavanone exposure without detectable short-term vascular benefits: a randomized crossover trial

Caroline Gilcher, Dragan Milenković, Marie Taillandier, Tatjana Ruskovska et autres

CON. Marked interindividual variability was observed in vascular responses and flavanone bioavailability, although treatment effects were unrelated to baseline endothelial function or flavanone exposure. Exploratory transcriptomic analyses suggested modulation of pathways involved in vascular biology following OJ and HESP. Under nutritionally realistic …

de, us, fr, mk (code pays fourni par la source)

Médecine de la douleur

Françoise Capriz, G T Pickering

Médecine de la douleur

Véronique Morel, G T Pickering

Médecine de la douleur

G T Pickering, Françoise Capriz

Estrategia de investigación sobre el dolor para europa: sondeo europeo y documento de posicionamiento de la federación Europea del Dolor EFIC

G T Pickering, Mary O'Keeffe, Kirsty Bannister, Susanne Becker et autres

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fr, ie, gb, de, at, il, dk, fi, pl, es, be, hr, nl, gr, rs, it (code pays fourni par la source)