Tatjana Ruskovska

Integrative functional bioinformatic analysis of NAD+-associated protein coding genes in adipose tissue (dys)function – evidence from targeted rodent transcriptomic studies

Filip Postolov, Dragan Milenković, Tatjana Ruskovska

One of the key regulatory mechanisms in adipose biology is the NAD + /SIRT axis, which is disrupted in conditions such as obesity and insulin resistance. In recent years, increasing attention has been directed toward understanding the role of NAD + in …

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Genetic Variability Determines Cardiometabolic Response to Orange Juice and Hesperidin Intake

Dragan Milenković, Caroline Gilcher, Nicolas Macian, Christine Morand et autres

Objectives: Several clinical studies have suggested that intake of orange juice and/or hesperidin has a positive effect on health outcomes. However, large interindividual variability in response has been described, which could be attributed to different factors, including genetic polymorphisms described in one …

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Efficacy of anthocyanins on cardiometabolic health: an umbrella review of meta-analyses of randomized controlled trials and observational studies

Emily Conrad, Brendan Kesler, Abbie Cawood, Anthony Lynn et autres

Non-communicable diseases (NCDs) remain the leading global health burden; according to the World Health Organization (WHO), seven out of the ten leading causes of death globally in 2021. Today, ischemic heart disease ranks first, and type 2 diabetes mellitus (the most common …

A lipidomics roadmap: from basic research to societal challenges

Maria Fedorova, Anne K. Bendt, Justine Bertrand-Michel, Oliver Fiehn et autres

Lipidomics, a rapidly evolving discipline at the interface of biology and analytical chemistry, seeks to comprehensively characterize the lipid composition of biological systems. Driven by advances in mass spectrometry, chromatography and computational analysis, lipidomics has enabled the high-resolution mapping of lipid networks …

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Obesity, Insulin Resistance and Dysregulation of the mTOR Signalling Pathway in Hidradenitis Suppurativa

Ivana Tusheva, Irena Dimitrovska, Vesna Trajkova, Vesna Brishkoska-Boshkovski et autres

BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent painful nodules, abscesses, and draining tunnels, with a predilection for intertriginous regions. AIM: We aimed to review dysregulation of mTOR signalling pathway based on the latest relevant scientific studies. …

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Obesity, insulin resistance and dysregulation of the mTOR signalling pathway in hidradenitis suppurativa

Ivana Tusheva, Irena Dimitrovska, Vesna Trajkova, Vesna Brishkoska Boshkovski et autres

BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent painful nodules, abscesses, and draining tunnels, with a predilection for intertriginous regions. AIM: We aimed to review dysregulation of mTOR signalling pathway based on the latest relevant scientific studies. …

Outcomes and future activities of the ‘Pan-European network in Lipidomics and EpiLipidomics – EpiLipidNET’

Julia Kuligowski, Justine Bertrand-Michel, Amaury Cazenave-Gassiot, Laura Goracci et autres

Background: Lipidomics and its branch epilipidomics are rapidly advancing fields that explore the roles of native and modified lipids (e.g., oxidized, nitrated and halogenated lipid species), respectively, in biological systems. Dysregulation of lipid metabolism and signaling contributes to numerous diseases, including cardiovascular, …

es, sg, ca, fi, se, is, at, us, pt, nl, gb, de (code pays fourni par la source)

Outcomes and future activities of the ‘Pan-European network in Lipidomics and EpiLipidomics – EpiLipidNET’

Julia Kuligowski, Justine Bertrand‐Michel, Amaury Cazenave-Gassiot, Laura Goracci et autres

BACKGROUND: Lipidomics and its branch epilipidomics are rapidly advancing fields that explore the roles of native and modified lipids (e.g., oxidized, nitrated and halogenated lipid species), respectively, in biological systems. Dysregulation of lipid metabolism and signaling contributes to numerous diseases, including cardiovascular, …

es, fr, sg, it, pt, fi, se, is, at, nl, gb, mk, rs, pl, de (code pays fourni par la source)

Integrative multi-layer bioinformatics of transcriptomic data for elucidating molecular mechanisms of action of polyphenol-rich extract on cardiometabolic health

Tatjana Ruskovska, Dragan Milenković

Polyphenols are bioactive compounds of plant origin, widely present in plants. Importantly, several hundreds of them are relevant for human nutrition. Numerous studies have shown that adequate daily polyphenol intake is associated with a beneficial effect on cardiometabolic health in humans. Despite …

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Orange juice and hesperidin increase flavanone exposure without detectable short-term vascular benefits: a randomized crossover trial

Caroline Gilcher, Dragan Milenković, Marie Taillandier, Tatjana Ruskovska et autres

CON. Marked interindividual variability was observed in vascular responses and flavanone bioavailability, although treatment effects were unrelated to baseline endothelial function or flavanone exposure. Exploratory transcriptomic analyses suggested modulation of pathways involved in vascular biology following OJ and HESP. Under nutritionally realistic …

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Pan-European network for inflammaging: a multi-omics integration approach (INFLAMomx)

Andrea Gelemanović, Biljana Stankovic, Ines Mollet, Ovidiu Radulescu et autres

The prevalence of noncommunicable diseases (NCDs) rises with age, placing a significant burden on public health. As the population ages, an increase in co- and multimorbidity is anticipated, making prevention a key scientific priority at the European level. In recent years, considerable …

Impact of (poly)phenol-rich dietary sources on DNA damage: insights from human intervention studies using the Comet assay – a review and perspective

M Milev, Boris Roglev, Maria Kondeva Rogleva, Milena Georgieva et autres

(Poly)phenols are plant-derived food bioactives abundantly present in human diet. They exert positive effects on various aspects of human health and in particular in reducing the risk of chronic non-communicable diseases. Dietary (poly)phenols have been reported to improve vascular function, blood lipids, …

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