Giacomo Colussi

Virtual augmentation of a simulated scenario for first aid operators training

Giacomo Colussi, Giovanni Serena, Federico Fontana, Fabio Buttussi

Simulations are frequently used in first aid training to help first aid operators experience real-world scenarios in a controlled, safe environment. In these simulations, special effects can be used to enhance the realism of the scene, such as fake blood and makeup. …

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Serum phosphate is associated with increased risk of bone fragility fractures in haemodialysis patients

Pedro Barrera-Baena, Minerva Rodríguez-García, Enrique Rodríguez-Rubio, Lucía González-Llorente et autres

BACKGROUND: Bone fragility fractures are associated with high morbidity and mortality. This study analysed the association between the current biochemical parameters of chronic kidney disease-mineral and bone disorders (CKD-MBD) and bone fragility fractures in the COSMOS (Current management Of Secondary hyperparathyroidism: a …

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Clinical and genetic characteristics of Dent's disease type 1 in Europe

Carla Burballa, Gerard Cantero-Recasens, Larisa Prikhodina, Francesca Lugani et autres

BACKGROUND: Dent's disease type 1 (DD1) is a rare X-linked nephropathy caused by CLCN5 mutations, characterized by proximal tubule dysfunction, including low molecular weight proteinuria (LMWP), hypercalciuria, nephrolithiasis-nephrocalcinosis, progressive chronic kidney disease (CKD) and kidney failure (KF). Current management is symptomatic and …

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End-proximal tubule phosphate concentration increases as GFR falls in humans: measurement by means of a lithium clearance-based methodology

Giacomo Colussi, Alberto Menegotto, Marialuisa Querques, Federica Ravera et autres

BACKGROUND: Microscopic nephrocalcinosis secondary to intratubular calcium phosphate (CaP) precipitation is thought to accelerate progression to end-stage renal failure in chronic kidney diseases. In phosphorus (P)-loaded uninephrectomized rats, intratubular CaP crystal formation and progressive tubular damage occurred when end-proximal tubule P concentration …

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Radiation dose from medical imaging in end stage renal disease patients: a Nationwide Italian Survey

Maurizio Postorino, Domenico Lizio, Andreana De Mauri, Carmela Marino et autres

BACKGROUND AND OBJECTIVES: End stage renal disease (ESRD) patients are exposed to the risk of ionizing radiation during repeated imaging studies. The variability in diagnostic imaging policies and the accompanying radiation doses across various renal units is still unknown. We studied this …

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Renal involvement in sarcoidosis: histological patterns and prognosis, an Italian survey.

Francesco Rastelli, Ivano Baragetti, Laura Buzzi, Francesca Ferrario et autres

BACKGROUND: Granulomatous interstitial nephritis in sarcoidosis (sGIN) is generally clinically silent, but in <1% causes acute kidney injury (AKI). METHODS: This Italian multicentric retrospective study included 39 sarcoidosis-patients with renal involvement at renal biopsy: 31 sGIN-AKI, 5 with other patterns (No-sGIN-AKI), 3 …

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A simple method for the calculation of dialysis Kt factor as a quantitative measure of removal efficiency of uremic retention solutes: Applicability to high-dialysate vs low-dialysate volume technologies

Giacomo Colussi, C. Brunati, Francesca Gervasi, Alberto Montoli et autres

Dialysis urea removal metrics may not translate into proportional removal efficiency of non-urea solutes. We show that the Kt factor (plasma volume totally cleared of any solutes) differentiates removal efficiency of non-urea solutes in different technologies, and can easily be calculated by …

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Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes

Paola Maffi, Torbjörn Lundgren, Gunnar Tufveson, Ehab Rafael et autres

OBJECTIVE Reparixin is an inhibitor of CXCR1/2 chemokine receptor shown to be an effective anti-inflammatory adjuvant in a pilot clinical trial in allotransplant recipients. RESEARCH DESIGN AND METHODS A phase 3, multicenter, randomized, double-blind, parallel-assignment study (NCT01817959) was conducted in recipients of …

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Single Session and Weekly Beta 2-Microglobulin Removal with Different Dialytic Procedures: Comparison between High-Flux Standard Bicarbonate Hemodialysis, Post-Dilution Hemodiafiltration, Short Frequent Hemodialysis with NxStage Technology and Automated Peritoneal Dialysis

C. Brunati, Francesca Gervasi, Mara Cabibbe, Federica Ravera et autres

BACKGROUND: NxStage System One cycler (NSO) is a widespread system for home daily dialysis. Few data are available on the impact of this "low dialysate volumes system" on the removal rate of poorly diffusible, time-dependent solutes like β2-microglobulin (β2M). METHODS: Single-session and …

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Treatment and long-term outcome in primary distal renal tubular acidosis

Sergio Camilo Lopez-Garcia, Francesco Emma, Stephen B. Walsh, Marc Fila et autres

BACKGROUND: Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment and long-term outcome. METHODS: We contacted paediatric and adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic and clinical data …

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Home hemodialysis treatment and outcomes: retrospective analysis of the Knowledge to Improve Home Dialysis Network in Europe (KIHDNEy) cohort

Shashidhar Cherukuri, M. Auxiliadora Bajo, Giacomo Colussi, Roberto Corciulo et autres

BACKGROUND: Utilization of home hemodialysis (HHD) is low in Europe. The Knowledge to Improve Home Dialysis Network in Europe (KIHDNEy) is a multi-center study of HHD patients who have used a transportable hemodialysis machine that employs a low volume of lactate-buffered, ultrapure …

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Long-Term Outcome and Treatment Practices in Distal Renal Tubular Acidosis

Sergio Camilo Lopez-Garcia, Francesco Emma, Stephen B. Walsh, Marc Fila et autres

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