Accès ouvert déclaré
2023
article
Serum phosphate is associated with increased risk of bone fragility fractures in haemodialysis patients
Pedro Barrera-Baena, Minerva Rodríguez-García, Enrique Rodríguez-Rubio, Lucía González-Llorente, Alberto Ortíz, Carmine Zoccali, Jürgen Floege, Martine Cohen‐Solal, Markus Ketteler, Gérard M. London, José Luis Górriz, J. Emilio Sánchez-Álvarez, Miguel Ángel Hevia-Suárez, J.M. Fernández Gómez, Beatriz Martín-Carro, Carlos Gómez‐Alonso, Cristina Alonso‐Montes, Jorge B. Cannata‐Andía, José Luis Fernández Martín, L Marosi, Bernhard Robl, Heinrich Kiss, Ulrich Neyer, Wilfried Jilly, Kramar, Dierik Verbeelen, Anne Wauters, R Cuvelier, C M De Mouscron, Max Dratwa, Chu Brugmann, Christian Tielemans, F. Dehout, Pierre Claus, A. Dhondt, B Jeren-Strujić, Marijana Gulin, Valentina Ćorić-Martinović, Draško Pavlović, Jana Smržová, Pavlikova, Valkovsky, Zahradnik, Vladimı́r Teplan, Pavukova, Nemocnice Poliklinikou, Dialyzacni Stredisko, Moucka Nemocnice, Overlæge Kjeld Otte, Fredericia Sygehus, James Heaf, Overlæge Henning Danielsen, Viborg Sygehus, Mari Kolunen, L L Markku Asola, Philit Jean-Baptiste, Philippe Nicoud, François-Louis Maurice, Mohamed Brahim Bounab, Philippe Bertocchio, Guillaume Jean, Bony Chantal, Pierre Grimal, J. Gaultier, Alex Mouneimne, Brignon, Dupuy, Jean-Paul Jaulin, Pablo Ureña, Marc Pocheville, Valérie Masson, Marc Uzan, Dominique Besnier, M Labeeuw, Głowacki, Cattanéo, Bois Guillaume, Bouchouareb, Petitjean Philippe, Dahmane Djamel, A N G Kim-Seng, Saveanu, Bouali Boussad, François-Pascal Wambergue, J.F. de Frémont, Michel, P Giraud, Jean-Paul Eche, Bernard S. López, Catherine Delcroix, Duchet, Ghandour Majdalani, Guy, Hadj, Marie-Paule Guillodo, Jochen Selbach, Arnold Röckel, B. Krumme, Bolley, M Grieger, Won-Ho Hahn, M. Daschner, Beate Iwig, Susanne Arendt, Dieter Berger, Bernd Wölbert, H Holzmann, Guenther Graf, Carsten Brockmann, W. J. Brech, A Mandelbaum, Wolfang Lauerwald, Johannes Bunia, Ulrich Lammer, Dieu Nguyet Au, Carsten Kurth, Schnierda, Stolz, Joachim Harlos, Steffen Berweck, Karl-August Brensing, Burkhard Kreft, Heinrich Jahnz, W. Kohnle, Wilfried Kamen, Sodemann, Peter Nachtigall, Jürgen Schäffer, Leimenstoll, K. Stenger, Wollschläger, Christine Langer, W Clasen, Christoph Röger, Klaus Burkhardt, J. P. Steinbach, Walter Schulz, Wolfgang Pommer, Michael Wilfling, Karla Schmaltz, Michael Eichhorn, E. Müller, Carola Striebing, H Schobel, Wolfgang Ludwig, Ulrich Frei, Helmut Peter Becker, Hans-Christoph Fischer, Maximilian Goller, Dieter Brückner, G Janning, Wolfgang Bagnewski, H. Preßler, Christoph C. Haufe, P. Grützmacher, Hans-Joachim Miska, Tomas Lenz, Olaf Frank Hoeft, Rolfdieter Krause, Kirsten de Groot, H. Armbruster, Peter Spellerberg, Wolfgang Stützer, Josef Nikolay, Rüdiger Schmidt, Johannes F.E. Mann, Rainer Roth, Johann-Borwin Lüth, Sybille Merscher, Hans-Jürgen Schmidt-Gürtler, Wolfgang Groß, Dehnert, Eva Roth, Stefan Heidenreich, Günter Bahlmann, Olaf Loke, Matthias Becker, Rolf Ebbinghaus, Matthias Weiß, Berhard Frye, F Matzkies, Katrin Gebauer, H-J Schurek, M. Heck, Helge Hohage, Ullrich Welling, M. Zeh, Schwietzer, Hermann Haller, U. Metz-Kurschel, Roland Fulde, Christoph Ganzemüller, Jörg Radermacher, Joachim Materna, Oliver Hebgen, Bernhard Weber, Dieter Hummel, Scheuerle, Joachim Beige, Ralf Lorenz, Dimitrios Plakias, Stauroula Solomakou, Georgios Bristogiannis, Kleonikos Kalaitzidis, Dimitrios Kavvadias, Dimitrios Memmos, Antonis Papantoniou, Kyriaki Stamatelou, Ioannis Stefanidis, Konstantinos Siamopoulos, Csaba Rikker, Imre Kulcsár, B. Tichy, Sándor Ferenczi, Andrea Hering, Ottó Árkossy, Judit Nagy, Ascanio de Gregorio, Gianmaria Frattini, Antonio La Corte, Ugo Rotolo, Diego Brancaccio, Maurizio Gallieni, Fusaro, A Albertazzi, Livia Nazzaro, Francesco Randazzo, C Lodeserto, Angela D’Angelo, Giovanni M. Frascà, Fabio Malberti, Deni Aldo Procaccini, Cesare Dell, Goffredo Del Rosso, E Dialisi, Spotti Donatella, Giuseppe Bianchi, Marco Biagini, Filippo Aucella, Antonio Scarlatella, A Jeantet, Marco Farina, Canulla Francesco, Maria Vittoria Cossu, Ssa Gina Meneghel, Mario Bonomini, Roberto Palla, Morosetti Massimo, Giancarlo Marinangeli, Rosella Estivi, Martin Giuliano, Renzo Scanziani, Conte Ferruccio, Giorgio Munatetto, Pastori Giordano, Giacomino Rossi, L Cagnoli, Massimo Morossetti, D Plutino, Alberto Galbiati, Loreto Gesualdo, M Querques, Giacomo Colussi, U Nefrologia, Andrea Macchi, Adalberto Tommasi, Eric F.H. van Bommel, Willem Jan W. Bos, Gaico H. Verseput, Louis Jean Vleming, C T Op De Hoek, Henk W. van Hamersvelt, Femke Hoekstra, H. A. H. Kaasjager, Magdalena Durlik, Miroslav Grzeszczyk, Andrzej Rydzewski, Dorota Śliwicka, Antoni Sydor, Tadeusz Gauda, Malgorzata Figarska, Szpital Powiatowy, Slawomir Trudnowski, Med Justyna Matulewicz-Gilewicz, Marek Sobocki, Jacek J Felisiak, R Rudka, Kizysztof Bidas, Paweł Krzywicki, Jarosław Hawryluk, Zdzisław Goździk, Oddzial Nefrologii, Krzysztof Dziewanowski, Cristina Resina, Fernando Carrera, Pedro Afonso Coelho Maia, J.F. Jiménez Cruz, Aníbal Ferreira, Ernesto Rocha, Doutor Rui Alves, P. Ponce, Sílvia Ribeiro, Ilídio Rodrigues, Radu Macavei, Adrian Covic, Cristian Gabriel Bako, Radu Alecsandru, Adrian Ghenu, O. Golea, Irinel Craciun, Ioana Iacob, Simona Kralj-Lopert, Marko Malovrh, Mihael Benedik, Milagros Ortiz, Ester Rubio, R. Rentero, S. Catalán Amigo, E. Mas, Josep Prim Gutiérrez, Guillermina Fernández Herrero, Ma Josefade la Torre Diz, Rafael Giner Seguí, J. Gonzalez, Carlos Santiago Guervas, Carmina Gómez Roldán, Fernando Vidaur Otegui, Guillermo Martín Reyes, Antonio de Paula de Pedro, Pilar Sánchez‐Pérez, Margarita López, Ma Carmen Prados Soler, Maria Dolores Paz Calvo, Rafael Romero Burgos, La Rosaleda, Pedro C Rodrigo Mateos, Dolores Arenas Jimenez, Aurelio Sanz, Björn Rogland, Margareta Karsberg, Alberto Gutiérrez, Stig Bucht, Michel Burnier, Pierre‐Yves Martin, Kistler Thomas, Claudio Marone, Rudolf P. Wüthrich, Peter D. McClelland, David Smithard, Ibi Erekosima, David Goldsmith, Thomas Mark, Martin Wilkie, Mike Cassidy, Morwenna Wood, Ramesh Naik, Patrick Harnett, Es J. Will, Charles G. Newstead
35Citations signalées — pas une note de qualité
22Institutions déclarées
5Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: Bone fragility fractures are associated with high morbidity and mortality. This study analysed the association between the current biochemical parameters of chronic kidney disease-mineral and bone disorders (CKD-MBD) and bone fragility fractures in the COSMOS (Current management Of Secondary hyperparathyroidism: a Multicentre Observational Study) project. METHODS: COSMOS is a 3-year, multicentre, open cohort, prospective, observational study carried out in 6797 haemodialysis patients (227 centres from 20 European countries). The association of bone fragility fractures (outcome) with serum calcium, phosphate and parathyroid hormone (PTH) (exposure), was assessed using standard Cox proportional hazards regression and Cox proportional hazards regression for recurrent events. Additional analyses were performed considering all-cause mortality as a competitive event for bone fragility fracture occurrence. Multivariable models were used in all strategies, with the fully adjusted model including a total of 24 variables. RESULTS: During a median follow-up of 24 months, 252 (4%) patients experienced at least one bone fragility fracture (incident bone fragility fracture rate 28.5 per 1000 patient-years). In the fractured and non-fractured patients, the percentage of men was 43.7% and 61.4%, mean age 68.1 and 63.8 years and a haemodialysis vintage of 55.9 and 38.3 months, respectively. Baseline serum phosphate >6.1 mg/dL (reference value 4.3-6.1 mg/dL) was significantly associated with a higher bone fragility fracture risk in both regression models {hazard ratio (HR) 1.53 [95% confidence interval (CI) 1.10-2.13] and HR 1.44 (95% CI 1.02-2.05)}. The significant association persisted after competitive risk analysis [subHR 1.42 (95% CI 1.02-1.98)] but the finding was not confirmed when serum phosphate was considered as a continuous variable. Baseline serum calcium showed no association with bone fragility fracture risk in any regression model. Baseline serum PTH >800 pg/mL was significantly associated with a higher bone fragility fracture risk in both regression models, but the association disappeared after a competitive risk analysis. CONCLUSIONS: Hyperphosphatemia was independently and consistently associated with an increased bone fracture risk, suggesting serum phosphate could be a novel risk factor for bone fractures in haemodialysis patients.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Serum phosphate is associated with increased risk of bone fragility fractures in haemodialysis patients
- Date Crossref
- 02/09/2023
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Parathyroid Disorders and TreatmentsDialysis and Renal Disease ManagementVitamin D Research Studies