Richard Z. Lin

Abstract 617: OSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA pathway.

Muhammad Usama Tariq, Namratha Sheshadri, Julia Shen, Jaeyong Jung et autres

Abstract Osteoclastogenesis-associated transmembrane protein 1 (OSTM1) is a membrane-integral glycosylated protein that regulates lysosomal homeostasis and osteoclast maturation. Its loss-of-function mutations cause autosomal recessive osteopetrosis (ARO). In addition, OSTM1 was described as a putative ubiquitin E3 ligase yet with ill-defined substrates and …

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Loss of PIK3CA Allows In Vitro Growth but Not In Vivo Progression of KRAS Mutant Lung Adenocarcinoma in a Syngeneic Orthotopic Implantation Model

Abigail Booth, Giuseppe Caso, Barbara Rosati, Ya-Ping Jiang et autres

Constitutively active KRAS mutations are highly prevalent in lung cancers, but the direct role of its downstream phosphatidylinositol 3-kinase (PI3K) pathway in tumor progression remains unclear. A previous study established the requirement for PIK3CA, the alpha catalytic isoform, in lung tumor development …

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Case Report: Deletion in the 5' untranslated region of TAFAZZIN in a boy with Barth syndrome

E. Singer, Janine A. Smith, Richard Z. Lin, A. Morrish et autres

Background Barth syndrome is an X-linked disorder characterised by cardiomyopathy, growth abnormalities, neutropenia, and 3-methylglutaconic aciduria. It is caused by pathogenic variants in TAFAZZIN , which encodes a mitochondrial protein essential for cardiolipin remodelling. In this study, we describe the case of …

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Loss of PIK3CA allows in vitro growth but not in vivo progression of KRAS mutant lung adenocarcinoma in a syngeneic orthotopic implantation model

Abigail Booth, Giuseppe Caso, Barbara Rosati, Y. Jiang et autres

Abstract Constitutively active KRAS mutations are highly prevalent in lung cancers, but the direct role of its downstream phosphatidylinositol 3-kinase (PI3K) pathway in tumor progression remains unclear. A previous study established the requirement for PIK3CA, the alpha catalytic isoform, in lung tumor …

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OSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA/CREB pathway

Muhammad Usama Tariq, Namratha Sheshadri, Jianliang Shen, Jaeyong Jung et autres

Abstract Osteoclastogenesis-associated transmembrane protein 1 (OSTM1) is a membrane-integral glycosylated protein known for regulating lysosomal homeostasis, with loss-of-function mutations causing autosomal recessive osteopetrosis. Through a whole-genome CRISPR/Cas9 screen, we identified OSTM1 as a critical tumor suppressor in B-cell malignancies. In humans, OSTM1 …

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Impaired nitrogenous waste clearance promotes hepatocellular carcinoma

Xinlu Han, Jianliang Shen, Junrong Yan, Rahul Tacke et autres

In mammals, hepatic urea cycle enzymes (UCEs) convert ammonia, the toxic nitrogenous waste, into urea for excretion. In hepatocellular carcinoma (HCC), UCE expression is often heterogeneously repressed, but its role in tumorigenesis is unclear. We show that, as in patients, UCE expression …

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Editorial commentary: Managing implantable cardioverter-defibrillators at end-of-life: Towards peaceful and dignified death

Richard Z. Lin, Shaun Evans, Dennis H. Lau

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Diagnosis and Management of Severe Left Main Disease With Concurrent Severe Thyrotoxicosis: A Case Report

Richard Z. Lin, Michael W. Hii, Wee Chian Lim, Linda My Huynh et autres

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Should routine dual antiplatelet therapy be recommended after elective coronary artery bypass surgery: insights from the DACAB-FE trial

Richard Z. Lin, J. Marathe, Peter J. Psaltis, Adam J. Nelson

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A CRITICAL ROLE FOR NEUTRAL SPHINGOMYELINASE-2 IN DOXORUBICIN-INDUCED CARDIOTOXICITY

Samia Mohammed, Yaping Jiang, Fabiola N. Velázquez, Sam B Chiappone et autres

ABSTRACT Cardiotoxicity is a major side effect of Doxorubicin (Dox) that has hampered its clinical utility, and strategies to mitigate this cardiotoxicity are limited. Sphingolipids (SL) are central to the chemotherapy response in cancer but their role in normal tissue is less …

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Author response: Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

Han V. Han, Richard Efem, Barbara Rosati, Kevin Lü et autres

Genome-wide CRISPR screen identified propionyl-CoA subunit B as a key regulator for anti-tumor T-cell activity in pancreatic cancer, which holds promise for advancing immunotherapy strategies in curing pancreatic cancer.

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Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

Han V. Han, Richard Efem, Barbara Rosati, Kevin Lü et autres

Most human pancreatic ductal adenocarcinoma (PDAC) are not infiltrated with cytotoxic T cells and are highly resistant to immunotherapy. Over 90% of PDAC have oncogenic KRAS mutations, and phosphoinositide 3-kinases (PI3Ks) are direct effectors of KRAS. Our previous study demonstrated that ablation …

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