Hideki Kawamura

Development of Vancomycin Population Pharmacokinetic Models for Pediatric Patients Using a Real-World Web Application Database

Kazutaka Oda, Kensuke Shoji, Kazuaki Matsumoto, Hideki Kawamura et autres

BACKGROUND: The Japanese Society of Chemotherapy developed practical area under the concentration-time curve (AUC)-guided therapeutic drug monitoring (PAT), a freely available web-based application widely used in Japan to support AUC-guided dosing of vancomycin. Its broad adoption has generated a substantial real-world pharmacokinetic …

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Fourth nationwide surveillance of the antimicrobial susceptibility patterns of pathogens isolated from surgical site infections in Japan

Norifumi Shigemoto, Hiroshige Mikamo, Hiroaki Hata, Junko Sato et autres

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Pitt candidaemia score as an assessment tool for mortality in patients with candidaemia caused by Candida tropicalis and other Candida species: a multicentre study conducted in Japan

Takashi Ueda, Hiroshi Kakeya, Koichiro Yoshida, Akihiro Hisato et autres

Abstract Background A bedside scoring system to assess the severity of disease is lacking for candidaemia. The Pitt candidaemia score (PCS) was evaluated for its association with mortality. Methods The PCS consists of five components, namely dialysis, hypotension, mechanical ventilation, cardiac arrest …

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P-2024. Multiple Cases of the Delta Substrain AY.29 with Casirivimab/Imdevimab Escape Mutation Identified in a Nosocomial COVID-19 Outbreak in a Hematology Ward

Yuka Hamada, Hideki Kawamura, Naomi Shinkawa, Makoto Kuroda

Abstract Background Underlying immunodeficiencies are a concern due to the risk of persistent infections of SARS-CoV-2. The Delta Substrain AY.29 with casirivimab/imdevimab escape mutations was detected from patients who was diagnosed as a COVID-19 while hospitalized in a hematology ward. This study …

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P-309. Spread of SCCmec IV type Community-acquired MRSA in a Tertiary Care ICU in Japan

Hideki Kawamura, Daisuke Okawa, Syuhei Niiyama, Naoko Imuta et autres

Abstract Background In recent years, community-acquired (CA) MRSA has become a problem, but there have been few reports of MRSA genotypes in the ICU. In our ICU, we have reinforced countermeasures such as screening for MRSA carriers using nasal specimens at admission …

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P-1961. Epidemiologic analysis of an alpha variant COVID-19 nosocomial cluster that occurred after completed vaccination of healthcare workers

Hideki Kawamura, Koji Nakano, Norihisa Hanada, Koji Sameshima

Abstract Background In a field where few reports have been made on the efficacy of SARS-CoV-2 vaccines in healthcare settings. We experienced an outbreak of an alpha variant in a medical institution cluster after healthcare workers were vaccinated, providing a novel perspective …

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Association between hospital case volume and mortality in pediatric sepsis: A retrospective observational study using a Japanese nationwide inpatient database

Shingo Ohki, Makoto Otani, Shinichi Tomioka, Kosaku Komiya et autres

Introduction: The survival benefits of treatment at high-volume hospitals (HVHs) are well-documented for several critical pediatric conditions. However, their impact on pediatric sepsis, a leading cause of mortality among children, remains understudied. Aim of the study: To investigate the association between hospital …

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A Novel Surgical Solution for Sciatic Hernia: Exploring the Totally Extraperitoneal Approach

Yuji Konishi, Yosuke Wakui, Kazuhiro Mino, Hideki Kawamura et autres

Sciatic hernia, a rare type of pelvic floor hernia, presents significant diagnostic and therapeutic challenges. We report the first totally extraperitoneal (TEP) repair of a sciatic hernia, which was performed in a 63-year-old woman who presented with vomiting and poor dietary intake. …

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Validation and development of population pharmacokinetic model of vancomycin using a real-world database from a nationwide free web application

Kazutaka Oda, Kazuaki Matsumoto, Kensuke Shoji, Akari Shigemi et autres

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Rapid response to a COVID-19 outbreak at a nightclub in Kagoshima prefecture, Japan, in the early phase of the COVID-19 pandemic, June and July 2020: A descriptive epidemiological study

Keisuke Kadokura, Hirofumi Kato, Kayoko Yoshizumi, Miyuki Kamikuri et autres

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Supplementary Material for: Prognostic nutritional index after introduction of atezolizumab with bevacizumab predicts prognosis in advanced hepatocellular carcinoma: A multicenter study

Tsutomu Suzuki, Kentaro Matsuura, Yūta Suzuki, Fumihiko Okumura et autres

Introduction: Atezolizumab plus bevacizumab (Atez/Bev) is the preferred treatment for advanced hepatocellular carcinoma (HCC). However, biomarkers of therapeutic efficacy have remained unclear. We took a retrospective approach to explore the role of prognostic nutritional index (PNI) for predicting the outcomes of Atez/Bev …

Safety and efficacy of PARP inhibitor rechallenge for platinum-sensitive recurrent ovarian cancer previously treated with a PARP inhibitor: a multicenter retrospective study

Ami Sato, Hideki Kawamura, Ryosuke Takeshita, Takeshi Aida et autres

Objective:The purpose of this study is to assess the prognostic implications of P53 mutation, estrogen receptor (ER) and progesterone receptor (PR) expression, and histologic type in postmenopausal patients diagnosed with International Federation of Gynaecology and Obstetrics stage 1 and 2 endometrial cancer …

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