Beáta Ramasz

EpCAM–PSMA: Potential predictors of treatment outcomes for PSMA-targeted alpha therapies in metastatic castration-resistant prostate cancer

Gábor Bakos, Ulrike Bauder‐Wüst, Jonathan Landry, Mareike Roscher et autres

Ac]Ac-PSMA-617, and we further explored the underlying molecular mechanisms. Using flow cytometry to profile EpCAM and PSMA on circulating tumor cells (CTCs), we observed that Nonresponders displayed significantly higher EpCAM and lower PSMA levels than Responders, both at baseline and after the …

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Current and Future Challenges in Cytometry: Reports of the CYTO 2025 Conference Workshops

Paul K. Wallace, Evan R. Jellison, Sherry Thornton, Kathleen Kluepfel et autres

joint effort begun in 2018 and continued in 2019 by Kamila Czechowska proved to be a valuable reference [1,2].Building on that spirit, we present summaries from CYTO 2025, held in Denver, Colorado, from May 31 to June 4.This manuscript serves as a …

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Cyt‐Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2025 Conference Workshops

Paul K. Wallace, Evan R. Jellison, Sherry Thornton, Kathleen Kluepfel et autres

joint effort begun in 2018 and continued in 2019 by Kamila Czechowska proved to be a valuable reference [1,2].Building on that spirit, we present summaries from CYTO 2025, held in Denver, Colorado, from May 31 to June 4.This manuscript serves as a …

us, gb, de, uy, be, ca, in, dk, es, nl, au, nz, ch, pt (code pays fourni par la source)

Surface Marker Diversity on Circulating Tumor Cells in Advanced Prostate Cancer Patients

Gábor Bakos, Ulrike Bauder-Wuest, Jonathan J. M. Landry, Mareike Roscher et autres

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Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster

Tamás Szlanka, Tamás Lukácsovich, Éva Bálint, Erika Viràgh et autres

One of the major functions of programmed cell death (apoptosis) is the removal of cells that suffered oncogenic mutations, thereby preventing cancerous transformation. By making use of a Double-Headed-EP (DEP) transposon, a P element derivative made in our laboratory, we made an …

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Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster

Tamás Lukácsovich, Tamás Szlanka, Éva Bálint, Kornélia Szabó et autres

Summary Apoptosis, the programmed cell death, is responsible for the removal of cells seriously damaged or unwanted in development. A major function of apoptosis is the removal of cells which suffered oncogenic mutations, thereby preventing cancerous transformation. By making use of the …

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High-speed fluorescence image–enabled cell sorting

Daniel Schraivogel, Terra M. Kuhn, Benedikt Rauscher, Marta Rodríguez‐Martínez et autres

Fast and selective isolation of single cells with unique spatial and morphological traits remains a technical challenge. Here, we address this by establishing high-speed image-enabled cell sorting (ICS), which records multicolor fluorescence images and sorts cells based on measurements from image data …

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3019 – SINGLE-CELL PROTEO-GENOMIC REFERENCE MAPS OF THE HEMATOPOIETIC SYSTEM ENABLE THE PURIFICATION AND MASSIVE PROFILING OF PRECISELY DEFINED CELL STATES

Dominik Vonficht, Sergio Triana, Lea Jopp‐Saile, Simon Raffel et autres

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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

Sergio Triana, Dominik Vonficht, Lea Jopp‐Saile, Simon Raffel et autres

Single-cell genomics technology has transformed our understanding of complex cellular systems. However, excessive cost and a lack of strategies for the purification of newly identified cell types impede their functional characterization and large-scale profiling. Here, we have generated high-content single-cell proteo-genomic reference …

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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

Sergio Triana, Dominik Vonficht, Lea Jopp‐Saile, Simon Raffel et autres

ABSTRACT Single-cell genomics has transformed our understanding of complex cellular systems. However, excessive costs and a lack of strategies for the purification of newly identified cell types impede their functional characterization and large-scale profiling. Here, we have generated high content single-cell proteo-genomic …

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Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases

Beáta Ramasz, Anja Krüger, Julia Reinhardt, Anupam N. Sinha et autres

Although bone marrow niche cells are essential for hematopoietic stem cell (HSC) maintenance, their interaction in response to stress is not well defined. Here, we used a mouse model of acute thrombocytopenia to investigate the cross talk between HSCs and niche cells …

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Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation

Odette Leiter, Suse Seidemann, Rupert W. Overall, Beáta Ramasz et autres

Physical activity is a strong positive physiological modulator of adult neurogenesis in the hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still unknown, systemic processes must be involved. Here we show that platelets are activated after acute periods of running, and …

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