Dick Frans Swaab

Impaired cholinergic function and an enhanced glymphatic component in the nucleus basalis of Meynert in individuals with Prader-Willi syndrome

Wei Jiang, Anne S. Versteegh, Han Jiao, Margje Sinnema et autres

nl, se (code pays fourni par la source)

Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer’s pathology and cognitive resilience

Giorgia Tosoni, Dilara Ayyildiz, Sarah Snoeck, Elena P. Moreno‐Jiménez et autres

The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain an open question. Although rodent studies have highlighted active roles for adult-born immature neurons in the hippocampus both under healthy conditions …

nl, us, gb, be, ch (code pays fourni par la source)

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Dennis D. Wever et autres

INTRODUCTION: Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS: Lipidomics and activity-based protein profiling (ABPP) were performed in …

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Sexual Dimorphic Accumulation of Hyperphosphorylated Tau in Tauopathies: The Possible Role of Estrogen Receptor α

Xinlu Chen, Mengyu Luo, Ya-Nan Zhang, Wenjin Lv et autres

cn (code pays fourni par la source)

Hoe kunst je brein prikkelt en in beweging zet

Dick Frans Swaab

Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus

Wei Jiang, Martin J. T. Kalsbeek, Felipe Corrêa‐da‐Silva, Han Jiao et autres

People with type 1 or type 2 diabetes mellitus (T1DM or T2DM) often experience cognitive impairment. We profiled cells in the nucleus basalis of Meynert (NBM) in postmortem human brain tissue to investigate the neuropathological changes. Sixty-eight postmortem NBM samples were grouped …

nl (code pays fourni par la source)

Veertig jaar Nederlandse Hersenbank: wat was de aanleiding om de bank te beginnen?

I. Huitinga, Dick Frans Swaab, Netherlands Brain Netherlands Brain Bank

Koningin Máxima bestudeert hersenplakjes onder de microscoop tijdens bezoek aan Hersenbank

I. Huitinga, Dick Frans Swaab, Netherlands Brain Netherlands Brain Bank

Hoe komt het dat mensen met dementie zo opknappen van muziek? En is dat effect blijvend?

Dick Frans Swaab

A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease‐related neuropathology

Anneke Alkemade, Pierre‐Louis Bazin, Evgeniya P. Kirilina, Kerrin Pine et autres

To bridge between detailed post-mortem neuropathological assessments and Magnetic Resonance Imaging (MRI), we have created and share a three-dimensional (3D) account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change. We combined multimodal imaging, using cryosectioning, histology, immunocytochemistry, and …

nl, de, tw, gb (code pays fourni par la source)

Het suïcidale brein

Dick Frans Swaab, Lin Zhang

Increased numbers of CD4 + T-cells in the hypocretin/orexin region of Narcolepsy Type 1

Ling Shan, Milo Fonville, Joost Smolders, Dick Frans Swaab

Abstract Narcolepsy type 1 (NT1) is proposed to be an autoimmune disorder targeting hypothalamic hypocretin (orexin, Hcrt) neurons. Hcrt reactive T-cells have been identified in blood and cerebrospinal fluid (CSF) of NT1 patients. However, it remains unknown whether T-cells infiltrate the brain. …

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