Xinyu Di

Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake

Bingni Chen, Aishvaryaa Prabhu, Li Guo, Anna Kaltenbach et autres

Peripheral cannabinoid CB1 receptor antagonists that lack central nervous system effects are emerging as promising therapies for metabolic disease, yet the role of endothelial CB1 signaling in atherosclerosis remains unclear. Here, we show that endothelial CB1 is expressed in human atherosclerotic plaques, …

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Endocannabinoid cerebrospinal fluid levels in migraine and its relation to symptoms of depression

Aster V. E. Harder, Xinyu Di, Wendy M. Winter, Bingshu He et autres

Background Disruption of the endocannabinoid system has been implicated in both migraine and depression, which are frequently comorbid in patients. Nevertheless, supporting evidence for this hypothesis is limited. Hence, we investigated whether the endocannabinoid system is disrupted in interictal migraine patients and …

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Foamy microglia link oxylipins to disease progression in multiple sclerosis

Daan van der Vliet, Xinyu Di, Tatiana M. Shamorkina, Claire Coulon-Bainier et autres

microglia/macrophages associated with lesion expansion in secondary progressive MS. Using integrated lipidomic, transcriptomic, proteomic, chemical proteomic and histological analyses of human postmortem MS lesions, we show that lesions containing foamy microglia/macrophages exhibit disrupted lipid metabolism, lysosomal stress and markers associated with heightened …

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Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Dennis Wever et autres

INTRODUCTION: Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS: Lipidomics and activity-based protein profiling (ABPP) were performed in …

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Foamy microglia link oxylipins to disease progression in multiple sclerosis

Netherlands Brain Bank, Daan van der Vliet, Xinyu Di, Tatiana M. Shamorkina et autres

Multiple sclerosis (MS) is a chronic neuroinflammatory disease in which demyelinating white matter lesions accumulate and expand, driving irreversible disability. Here we identify a distinct population of foamy GPNMB + microglia/macrophages associated with lesion expansion in secondary progressive MS. Using integrated lipidomic, …

α-Methyltryptophan mitigates cognitive impairment in db/db mice: involvement of gut-brain metabolic remodeling

Aimin Cai, Qiushuang Xiong, Xinyu Di, Yun Yan et autres

BACKGROUND: Cognitive dysfunction in diabetes significantly impairs quality of life, yet effective therapies remain limited. Our previous work showed that α-methyltryptophan (α-MT), an inhibitor of the amino acid transporter SLC6A14 and indoleamine 2,3-dioxygenase 1 (IDO1), ameliorates diabetic nephropathy by modulating renal metabolism. …

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Inhibition of endocannabinoid synthesis enzymes DAGL and NAPE-PLD transiently lowers body weight and alters glucose homeostasis during a high-fat diet challenge in mice

Robin van Eenige, Elena Sánchez‐López, Anna T. Hoekstra, Zhixiong Ying et autres

BACKGROUND: Cannabinoid receptor 1 inhibition poses an effective treatment strategy in obesity, but has a risk of psychiatric side effects. As high-fat diet (HFD)-feeding acutely increases expression of endocannabinoid synthesis enzymes and circulating endocannabinoid levels in mice, here we tested whether inhibition …

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Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress

Sabine Steffens, Bingni Chen, Aishvaryaa Prabhu, Li Guo et autres

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Moderate-intensity exercise training uniquely modulates circulating lipid species beyond classical lipid levels in humans

Yu Zhang, Zhengzheng Zhang, Borja Martínez‐Téllez, Xinyu Di et autres

Background Regular physical exercise shows significant health-related benefits, potentially through the modulation of lipid metabolism in an intensity-dependent manner. Methods In this study, we profiled 794 plasma lipid species across 18 subclasses following a 24-week supervised concurrent and randomised exercise intervention at …

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Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer’s disease

Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Marc T.C. van der Meij et autres

Abstract Introduction While it has become clear that alterations in lipid metabolism are associated with AD, it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. Methods We performed lipidomics and activity-based protein profiling in the frontal …

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Lipidomic profiling of triple-negative breast cancer cells reveals distinct metabolic signatures associated with EpCAM expression

Xiaoyue Huang, Xinyu Di, Melissa Celine Zuiderwijk, Lu Zhang et autres

Lipid metabolism is essential at all stages of cancer progression, particularly for triple-negative breast cancer (TNBC) the deadliest cancer subtype for women patients. TNBC cells exhibit significant metabolic heterogeneity, which contributes to their aggressive behavior. Epithelial-to-mesenchymal transition (EMT), a key step in …

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Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress

Bingni Chen, Aishvaryaa Prabhu, Li Guo, Anna Kaltenbach et autres

ABSTRACT Background Peripherally restricted cannabinoid CB1 receptor antagonists without central side effects hold promise for treating metabolic disorders including diabetes and obesity. In atherosclerosis, the specific effects of peripheral CB1 signaling in vascular endothelial cells (ECs) remain incompletely understood. Methods and results …

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