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2026
report
OpenAlex
Theo Zacharis, Sheraz Gul, Bruno Nunes, Paul M. Selzer et autres
Vector-borne parasitic diseases (VBDs), including leishmaniasis, trypanosomiases, schistosomiasis and babesiosis, pose an escalating threat to human and animal health across Europe and globally. Approximately 75% of emerging human infections originate from animals, and VBDs account for roughly 17% of the global infectious …
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Accès ouvert
2026
report
OpenAlex
Theo Zacharis, Sheraz Gul, Bruno Nunes, Paul M. Selzer et autres
Vector-borne parasitic diseases (VBDs), including leishmaniasis, trypanosomiases, schistosomiasis and babesiosis, pose an escalating threat to human and animal health across Europe and globally. Approximately 75% of emerging human infections originate from animals, and VBDs account for roughly 17% of the global infectious …
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2026
article
OpenAlex
Evangelos Tsoukas, Michail Papadourakis, Eleni Chontzopoulou, Spyridon Vythoulkas et autres
High Resolution Image Download MS PowerPoint Slide Pharmaceutical pollution in aquatic environments poses a significant ecological threat due to the accumulation of bioactive compounds from human and veterinary sources. In support of the EU Green Deal’s Chemicals Strategy for Sustainability, this study …
gr
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2025
article
OpenAlex
Eleni Chontzopoulou, Andromachi Tzani, Katerina Paschalidou, Nikoletta Zoupanou et autres
High Resolution Image Download MS PowerPoint Slide A frequent challenge that graduate and undergraduate students in chemistry, biology, and pharmacy laboratories face is accurately assigning proton and carbon peaks in the 1D and 2D Nuclear Magnetic Resonance (NMR) spectra of organic and …
gr
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2024
article
OpenAlex
Nikitas Georgiou, Eleni Chontzopoulou, Efthymios Alexandros Routsi, I. Stavrakaki et autres
The rational design of AT1 receptor antagonists represents a pivotal approach in the development of therapeutic agents targeting cardiovascular pathophysiology. Sartans, a class of compounds engineered to inhibit the binding and activation of Angiotensin II on the AT1 receptor, have demonstrated significant …
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2024
article
OpenAlex
Alexandros-Timotheos Loukas, Michail Papadourakis, Vasilis Panagiotopoulos, Apostolia Zarmpala et autres
Osteoporosis, characterized by reduced bone density and increased fracture risk, affects over 200 million people worldwide, predominantly older adults and postmenopausal women. The disruption of the balance between bone-forming osteoblasts and bone-resorbing osteoclasts underlies osteoporosis pathophysiology. Standard treatment includes lifestyle modifications, calcium …
gr
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2023
article
OpenAlex
Kalliopi Moschovou, Maria Christina Antoniou, Eleni Chontzopoulou, Konstantinos D. Papavasileiou et autres
In this in silico study, we conducted an in-depth exploration of the potential of natural products and antihypertensive molecules that could serve as inhibitors targeting the key proteins of the SARS-CoV-2 virus: the main protease (Mpro) and the spike (S) protein. By …
gr, cy
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2023
article
OpenAlex
Nikitas Georgiou, Eleni Chontzopoulou, Antigoni Cheilari, Aikaterini Katsogiannou et autres
High Resolution Image Download MS PowerPoint Slide The potential of the 4,6-diphenyl-3,4-dihydropyrimidine-2(1 H )-thione (abbreviated as KKII5 ) and ( E )- N ′-benzylidenehydrazinecarbothiohydrazide (abbreviated as DKI5 ) compounds as possible drug leads is investigated. KKII5 and DKI5 are synthesized in high …
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2022
article
OpenAlex
Nikitas Georgiou, Antigoni Cheilari, Danai Karta, Eleni Chontzopoulou et autres
The structure assignment and conformational analysis of the thiosemicarbazones, DKI21 and DKI24, were performed through homonuclear and heteronuclear 2D Nuclear Magnetic Resonance (NMR) spectroscopy (2D-COSY, 2D-NOESY, 2D-ROESY, 2D-HSQC, and 2D-HMBC) and quantum mechanics (QM) calculations, using Functional Density Theory (DFT). In addition, …
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2021
article
OpenAlex
Nikitas Georgiou, Niki Gouleni, Eleni Chontzopoulou, George S. Skoufas et autres
The structure assignment and conformational analysis of cinnamic derivative N-benzyl-N-(2-(cyclohexylamino)-2-oxoethyl) cinnamamide (NGI25) was carried out through Nuclear Magnetic Resonance (NMR) spectroscopy, Molecular Dynamics (MD) and Quantum Mechanics (QM), i.e. semiempirical and Density Functional Theory (DFT) calculations. Moreover, Homonuclear (COSY, NOESY) and heteronuclear …
gr
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2021
article
OpenAlex
Eleni Chontzopoulou, Christina D. Papaemmanouil, Μaria V. Chatziathanasiadou, Dimitrios Kolokouris et autres
Repurposing existing drugs, as well as natural and artificial sweeteners for novel therapeutic indications could speed up the drug discovery process since numerous associated risks and costs for drug development can be surpassed. In this study, natural and artificial sweeteners have been …
gr
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2021
article
OpenAlex
Violeta Kourbeli, Eleni Chontzopoulou, Kalliopi Moschovou, Dimitrios Pavlos et autres
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and leishmaniases span worldwide and therefore their impact is a universal concern. The present regimen against kinetoplastid protozoan infections is poor and insufficient. Target-based design expands the horizon of drug design and …
gr
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