Xuezhao Feng

An antibiotic that mediates immune destruction of senescent cancer cells

Gabriele Casagrande Raffi, Jian Chen, Xuezhao Feng, Zhen Chen et autres

Drugs that eliminate senescent cells, senolytics, can be powerful when combined with prosenescence cancer therapies. Using a CRISPR/Cas9-based genetic screen, we identify here SLC25A23 as a vulnerability of senescent cancer cells. Suppressing SLC25A23 disrupts cellular calcium homeostasis, impairs oxidative phosphorylation, and interferes …

nl, cn (code pays fourni par la source)

An antibiotic that mediates immune destruction of senescent cancer cells

Gabriele Casagrande Raffi, Jian Chen, Xuezhao Feng, Zhen Chen et autres

Abstract Drugs that eliminate senescent cells, senolytics, can be powerful when combined with pro-senescence cancer therapies. Using a CRISPR/Cas9-based genetic screen, we identify here SLC25A23 as a vulnerability of senescent cancer cells. Suppressing SLC25A23 disrupts cellular calcium homeostasis, impairs oxidative phosphorylation and …

nl, cn (code pays fourni par la source)

Local membrane source gathering by p62 body drives autophagosome formation

Xuezhao Feng, Daxiao Sun, Yanchang Li, Jinpei Zhang et autres

Autophagosomes are double-membrane vesicles generated intracellularly to encapsulate substrates for lysosomal degradation during autophagy. Phase separated p62 body plays pivotal roles during autophagosome formation, however, the underlying mechanisms are still not fully understood. Here we describe a spatial membrane gathering mode by …

cn, de (code pays fourni par la source)

Myosin 1D and the branched actin network control the condensation of p62 bodies

Xuezhao Feng, Wanqing Du, Mingrui Ding, Wenkang Zhao et autres

cn (code pays fourni par la source)

Acteoside exerts neuroprotection effects in the model of Parkinson's disease via inducing autophagy: Network pharmacology and experimental study

Mutalifu Aimaiti, Ainiwaer Wumaier, Yiliyasi Aisa, Yu Zhang et autres

cn (code pays fourni par la source)

BF12, a Novel Benzofuran, Exhibits Antitumor Activity by Inhibiting Microtubules and the PI3K/Akt/mTOR Signaling Pathway in Human Cervical Cancer Cells

Yiting Gao, Cheng Ma, Xuezhao Feng, Yang Liu et autres

Abstract BF12 [(2E)‐3‐[6‐Methoxy‐2‐(3,4,5‐trimethoxybenzoyl)‐1‐benzofuran‐5‐yl]prop‐2‐enoic acid], a novel derivative of combretastatin A‐4 (CA‐4), was previously found to inhibit tumor cell lines, with a particularly strong inhibitory effect on cervical cancer cells. In this study, we investigated the microtubule polymerization effects and apoptosis signaling mechanism …

cn (code pays fourni par la source)