Ndaba Mazibuko

Deviations in effective connectivity explain different hallucination subtypes in Parkinson’s disease psychosis

Miriam Vignando, Dominic H Ffytche, Ndaba Mazibuko, Giulio Palma et autres

Abstract Psychosis and visual hallucinations (VH) in Parkinson’s disease (PD) substantially impact patient outcomes, yet the underlying neural mechanisms remain unclear, limiting effective treatments. Here we used dynamic causal modeling to leverage the fast temporal dynamics captured with electroencephalography data during a …

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Differential effects of a single dose of Lisdexamfetamine and Guanfacine on cognitive function in children with ADHD

Sahid El Masri, Olivia S. Kowalczyk, Marion Criaud, Steve Lukito et autres

Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with cognitive difficulties which improve with traditional stimulant and non-stimulant medications. However, there is limited evidence on the cognitive effects of the newer licensed stimulant lisdexamfetamine and non-stimulant guanfacine in children with ADHD. Therefore, we compared …

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The GPR139 agonist TAK-041 produces time-dependent alterations to cerebral blood flow and reward system function in patients with schizophrenia: a randomised placebo-controlled trial

Peter C.T. Hawkins, Adam James Schwarz, James M. Stone, Fiona Pepper et autres

The negative and cognitive symptoms of schizophrenia are predictive of quality of life and functional recovery, but there are no approved drug options that target these symptoms directly. TAK-041 (also known as NBI-1065846) is a selective and potent small-molecule agonist of GPR139, …

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Anomalies in effective connectivity explain different hallucination subtypes in Parkinson’s disease psychosis

Miriam Vignando, Dominic H Ffytche, Ndaba Mazibuko, Giulio Palma et autres

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Corrigendum to “Mifepristone enhances the neural efficiency of human visuospatial memory encoding and recall” [Psychoneuroendocrinology 125 (2021) 105116]

Nefize Yalın, Matthew J. Kempton, Ndaba Mazibuko, Mitul Ashok Mehta et autres

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Novel Lipid Formulation Increases Absorption of Oral Cannabidiol (CBD)

Edward Chesney, Ndaba Mazibuko, Dominic Oliver, Amedeo Minichino et autres

Background: Cannabidiol (CBD) is an approved treatment for childhood epilepsies and a candidate treatment for several other CNS disorders. However, it has poor oral bioavailability. We investigated the effect of a novel lipid formulation on its absorption in humans and on its …

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Visual mismatch negativity in Parkinson's psychosis and potential for testing treatment mechanisms

Miriam Vignando, Dominic H Ffytche, Ndaba Mazibuko, Giulio Palma et autres

Abstract Psychosis and visual hallucinations are a prevalent non-motor symptom of Parkinson's disease, negatively affecting patients’ quality of life and constituting a greater risk for dementia. Understanding neural mechanisms associated to these symptoms is instrumental for treatment development. The mismatch negativity is …

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Serial intravenous ketamine in treatment resistant depression produces reductions in symptoms and cerebral perfusion in reward and emotion-related brain regions

Peter R. Hawkins, Matthew Burrows, Geor Bakker, Kristiina Kompus et autres

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Acute effects of mifepristone on emotional processing related brain activity: A functional MRI study

Nefize Yalın, Matthew J. Kempton, Ndaba Mazibuko, Mitul Ashok Mehta et autres

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Comparison of Cerebral Blood Flow in Regions Relevant to Cognition After Enzalutamide, Darolutamide, and Placebo in Healthy Volunteers: A Randomized Crossover Trial

Steven Williams, Ndaba Mazibuko, Owen O’Daly, Christian Zurth et autres

Off-target central nervous system (CNS) effects are associated with androgen receptor (AR)-targeting treatments for prostate cancer. Darolutamide is a structurally distinct AR inhibitor with low blood–brain barrier penetration. We compared cerebral blood flow (CBF) in grey matter and specific regions related to …

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The effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats

Nisha Singh, Eilidh MacNicol, Ottavia Dipasquale, Karen Randall et autres

Methylene Blue (MB) is a brain-penetrating drug with putative neuroprotective, antioxidant and metabolic enhancing effects. In vitro studies suggest that MB enhances mitochondrial complexes activity. However, no study has directly assessed the metabolic effects of MB in the human brain. We used …

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The effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats

Nisha Singh, Eilidh MacNicol, Ottavia Dipasquale, Karen Randall et autres

Abstract Methylene Blue (MB) is a brain-penetrating drug with putative neuroprotective, antioxidant and metabolic enhancing effects. In vitro studies suggest that MB enhances mitochondrial complexes activity. However, no study has directly assessed the haemodynamic and metabolic effects of MB in the human …

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