Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8
Katy Billot, Charlène Coquil, Benoît Villiers, Béatrice Josselin-Foll et autres
Following the discovery of (R)-roscovitine's beneficial effects in three polycystic kidney disease (PKD) mouse models, cyclin-dependent kinases (CDKs) inhibitors have been investigated as potential treatments. We have used various affinity chromatography approaches to identify the molecular targets of roscovitine and its more …
fr, us, de, ca (code pays fourni par la source)
7 citations
American Journal of Physiology-Renal Physiology