Development of CBCT-Guided Online Adaptive Radiotherapy
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Online adaptive radiotherapy (oART) can change the dose distribution briefly to match the shape of the targets and organs at risk. Cone-beam computed tomography (CBCT)-guided oART has been introduced in clinical practice and is expected to improve clinical outcomes. This technology allows treatment as an extension of conventional CT-based image-guided radiotherapy technology and has the advantage of relatively short treatment times. However, the clinical and dosimetric benefits of oART have not yet been adequately reported. Methods: We systematically reviewed previous studies evaluating CBCT-guided oART in patients with malignancies. Case reports, conference abstracts, letters, editorials, and reviews were excluded. PubMed was searched from January 2019 to 22 November 2025, supplemented by hand searching. Study design, cancer site, workflow, treatment time, dosimetric outcomes, feasibility, and clinical outcomes were extracted. Owing to clinical and methodological heterogeneity, findings were synthesized narratively. Results: A total of 127 studies were included. Across most studies, adapted plans improved target coverage and reduced or maintained doses to organs at risk compared with scheduled plans. This review provides an overview of the workflows and latest developments in CBCT-guided oART. Furthermore, the clinical and dosimetric benefits at each site, including the chest, abdomen, pelvis, head, and neck, are shown. Conclusions: The development of oART is expected to lead to the introduction of personalized medicine and improve the clinical outcomes of patients with various cancers. Further research and clinical trials are warranted to establish CBCT-guided oART. This review received no external funding and was registered in PROSPERO (CRD420251237632).
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Development of CBCT-Guided Online Adaptive Radiotherapy
- Date Crossref
- 25/08/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Jichi Medical University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Kyoto University pays non établi dans la noticeUniversité ou école supérieure
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Kyushu University pays non établi dans la noticeUniversité ou école supérieure
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Kagoshima University pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Medicine Department of Radiation Oncology and Image-Applied Therapy pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Medical Sciences Department of Clinical Radiology pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Medical and Dental Sciences Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
Department of Radiology — Jichi Medical University, Kyoto University et Kyushu University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.