Guanghong Wei

Pathological Mutation E46K Acts as an Electrostatic Switch to Increase Distant Interdomain Interactions and Promote α-Synuclein Phase Separation

Zhongyuan Yang, Yiming Tang, Jitao Wen, Cong Guo et autres

The Parkinson's disease-related protein α-synuclein can form solid amyloid fibrils through liquid-liquid phase separation (LLPS) and liquid-to-solid phase transition. The most deleterious familial mutation E46K has recently been shown to enhance α-synuclein LLPS and subsequent solidification; yet, the precise mechanisms remain largely …

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The value of third-generation sequencing for neonatal screening of thalassemia in the Yulin region of Southern China

Sisi Ning, Shibin He, Guanghong Wei, Yi Liang et autres

Background: Thalassemia is one of the most prevalent and severe monogenic disorders worldwide. In China, a three-tiered prevention and control strategy has been established for this disease, comprising preconception carrier screening, prenatal diagnosis, and neonatal screening. However, the implementation of neonatal thalassemia …

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Underlying Polymorphism: Superhelical Crystallization Induces Architectural and Functional Diversity

Yan Zhang, Tong Pan, Sarah Guerin, Jiahao Zhang et autres

Crystallized peptide assemblies have demonstrated useful physicochemical and electromechanical features due to the highly ordered supramolecular packing driven by efficient and extensive non-covalent interactions. However, the structural polymorphism of the bioinspired self-assemblies poses challenges for their rational design and scale production as …

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Histidine Containing Minimalistic‐Peptide‐Based Nanostructured Hydrogel for Multiple Enzyme‐Mimicking Catalytic Activities

Vivek Vishwanath Adole, Zichao Wang, Yiming Tang, Gayatri Mishra et autres

Abstract The exceptional catalytic prowess of native enzymes is inherited from their ability to fold into distinctive arrangements with appropriate positioning of the amino acid constituents. Thanks to their selective and efficacious catalytic competence, enzymes play a critical role in industry and …

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Stoichiometry-Controlled Structural Transformation of Diphenylalanine Nanoassemblies through Coassembly with Charged Dipeptides

Yiming Tang, Zhongyuan Yang, Junli Yang, Jiyuan Zeng et autres

Peptide self-assembly produces a wide range of well-structured nanostructures, offering significant potential for biomedical and nanotechnological applications. However, controlling the morphologies of these assemblies is considerably challenging due to their intricate polymorphisms and complex responsiveness to environmental changes. In this study, we …

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Dissecting the Molecular Determinants of α‐synuclein Phase Separation and Condensate Aging: The Pivotal Role of β‐Sheet‐Rich Motifs

Yiming Tang, Jitao Wen, Zhongyuan Yang, Yifei Yao et autres

Emerging evidence indicates that liquid-liquid phase separation of α-synuclein occurs during the nucleation step of its aggregation, a pivotal step in the onset of Parkinson's disease. Elucidating the molecular determinants governing this process is essential for understanding the pathological mechanisms of diseases …

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Discrete Actuation of Water‐Responsive Crystalline Metal–Peptide Frameworks

Hui Liang Yuan, Yiming Tang, Elma Naranjo, Pierre‐André Cazade et autres

Abstract Engineering guest‐responsive materials capable of controlled and precise sorption behavior and structural deformation in response to external stimuli is imperative for various applications. However, existing systems often exhibit complex, unpredictable dynamics, posing challenges for efficient control and utilization. Here, we design …

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Discrete Actuation of Water‐Responsive Crystalline Metal–Peptide Frameworks

Hui Yuan, Yiming Tang, Elma Naranjo, Pierre‐André Cazade et autres

Engineering guest-responsive materials capable of controlled and precise sorption behavior and structural deformation in response to external stimuli is imperative for various applications. However, existing systems often exhibit complex, unpredictable dynamics, posing challenges for efficient control and utilization. Here, we design crystalline …

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Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior

Jitao Wen, Yiming Tang, Tomas Šneideris, Hannes Ausserwӧger et autres

Liquid-liquid phase separation (LLPS) is now recognized as one of the key mechanisms underlying the formation of membraneless organelles. Typically, condensates formed through LLPS are dynamic and play a crucial role in the spatiotemporal regulation of essential cellular processes. In some cases, …

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Comparative Study of a Variant Neural Relational Inference Deep Learning Model and Dynamical Network Analysis for p53-DNA Allosteric Interactions

Haoxin Sun, Jingbo Wei, Yiming Tang, Tianjing Guo et autres

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Effect of solvent-induced packing transitions on N-capped diphenylalanine peptide crystal growth

Yoav Dan, Zohar A. Arnon, Yiming Tang, Mathar Kravikass et autres

Self-assembled supramolecular materials have gained extensive interest due to their ability to form structures with diverse physical, chemical, and biological properties. These characteristics arise from the precise arrangement of building blocks at the nanoscale. There is an unmet need to efficiently manipulate …

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pH ‐Dependent β‐Strand Alignment of the Alzheimer's Amyloid‐β (16–22) Peptide

Junfeng Wan, Yin Luo, Philippe Derreumaux, Guanghong Wei et autres

The extracellular amyloid plaques of amyloid-β (Aβ) peptides formed in the human brain are an important pathological hallmark of Alzheimer's disease. There is evidence that pH affects the morphologies of fibrils and the kinetics of amyloid fibril formation. However, the underlying molecular …

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