Daniel Klinger

Numerical estimation of drug loading contents in amphiphilic nanogels

Ante Markovina, Clara López Iglesias, Ruiguang Cui, Daniel Klinger

to drug loading content across diverse ANG-drug systems. Consequently, our framework suggests predictive potential of solubility parameter-based models, reduces experimental burden, and supports the rational design of ANG carriers tailored to specific hydrophobic drugs.

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Numerical estimation of drug loading contents in amphiphilic nanogels

Ante Markovina, Clara López-Iglesias, Ruiguang Cui, Daniel Klinger

Amphiphilic nanogels (ANGs) are promising colloidal carriers to improve bioavailability of poorly water-soluble drugs. In contrast to conventional hydrophilic nanogels, ANGs contain additional hydrophobic domains in their network to load hydrophobic cargos. However, optimizing drug loading remains labour-intensive due to the lack …

Sulfonium‐Based Antimicrobial Block Copolymers: Influence of Hydrophobicity on Biological Activity and Antibiotic Synergy

Sidra Kanwal, Otto Staudhammer, Umer Bin Abdul Aziz, Elisa Quaas et autres

Antimicrobial polymers (AMP) are promising therapeutics to target bacterial pathogens. Sulfonium-based AMPs offer a good balance between high antimicrobial activity and low cytotoxicity. Currently, sulfonium groups are mostly incorporated into random copolymers that combine these cations with hydrophobic and neutral hydrophilic groups. …

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Multi‐Responsive Nanogels Based on Sulfoxide Polymethacrylates for Biomedical Applications

Clara López‐Iglesias, Sidra Kanwal, Elisa Quaas, Daniel Klinger

ABSTRACT Nanogels for biomedical applications require polymeric building blocks that show high hydrophilicity and (thermo‐)responsive properties without immune response risks. Polysulfoxides offer these advantages but have not yet been translated to 3‐dimensional colloidal materials. To examine their potential as alternatives to established …

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Sulfonium-based polymethacrylamides for antimicrobial use: influence of the structure and composition

Sidra Kanwal, Umer Bin Abdul Aziz, Elisa Quaas, Katharina Achazi et autres

Structure–property relations for antimicrobial sulfonium-based polymers reveal that same-center structures show superior activity and selectivity compared to different-center and ammonium-based analogues of similar clog P .

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Nanogels with tailored hydrophobicity and their behavior at air/water interfaces

Ruiguang Cui, Maret Ickler, Johannes Menath, Nicolas Vogel et autres

-(2-hydroxypropyl)methacrylamide) (PHPMA) nanogels as a hydrophilic benchmark and introduce gradually varied amounts of hydrophobic propyl or dodecyl moieties to increase the nanogel hydrophobicity. We study the deformation and arrangement of these particles at an air/water interface and correlate the results with quantitative …

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Ruiguang Cui, Maret Ickler, Daniel Klinger, Nicolas Vogel et autres

Amphiphilic Nanogels as Versatile Stabilizers for Pickering Emulsions

Ruiguang Cui, Maret Ickler, Ante Markovina, Sidra Kanwal et autres

High Resolution Image Download MS PowerPoint Slide Pickering emulsions (PEs) are stabilized by particles at the water/oil interface and exhibit superior long-term stability compared to emulsions with molecular surfactants. Among colloidal stabilizers, nano/microgels facilitate emulsification and can introduce stimuli responsiveness. While increasing …

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Optically monitoring the microenvironment of a hydrophobic cargo in amphiphilic nanogels: influence of network composition on loading and release

Clara López‐Iglesias, Ante Markovina, Nithiya Nirmalananthan‐Budau, Ute Resch‐Genger et autres

, at the nanodomain border, and favored dye-dye interactions and NR aggregation. These results correlate well with release experiments, indicating first NR release from more hydrophilic network locations. Overall, our findings demonstrate the importance to understand carrier-drug interactions for efficient loading and …

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Poly( N -acryloylmorpholine) Nanogels as Promising Materials for Biomedical Applications: Low Protein Adhesion and High Colloidal Stability

Thi Mai Phuong Neumann‐Tran, Clara López‐Iglesias, Lucila Navarro, Elisa Quaas et autres

Poly( N -acryloylmorpholine) (P(NAM))-based materials have been developed to prevent protein adhesion to surfaces due to their biocompatibility and protein-repellent properties. However, transferring the benefits of P(NAM) to nanoscale materials such as nanogels has not yet been studied. This can be attributed …

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Rational Design and Development of Polymeric Nanogels as Protein Carriers

Clara López‐Iglesias, Daniel Klinger

Proteins have gained significant attention as potential therapeutic agents owing to their high specificity and reduced toxicity. Nevertheless, their clinical utility is hindered by inherent challenges associated with stability during storage and after in vivo administration. To overcome these limitations, polymeric nanogels …

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Synthesis of New Degradable AB-Type Polyesters with 1,2,3-Triazole Rings in the Backbone via “Click” Step-Growth Polymerization

Tengiz Kantaria, Temur Kantaria, Alexandre Vanishvili, Sophiko Kvinikadze et autres

A series of new aliphatic AB-type polyesters (PEs) and co-polyesters (co-PEs) with 1,2,3-triazole rings in the backbone were successfully synthesized via Cu(I)-catalyzed click step-growth polymerization (SGP) following the efficient one pot/two step synthetic strategy. The structure of the click polymers was confirmed …

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