Lukas Endler

Gut-derived ammonia modulates hypothalamic stress responses during viral infection

Henrique G. Colaço, Anna Gundacker, Aubrey Burrett, Christian Grozev et autres

Abstract The gut–brain axis integrates microbial and host metabolism to regulate systemic physiology, yet its role during viral infection remains poorly defined. Viral infection induces behavioral changes and neuroendocrine stress responses accompanied by profound alterations in gut microbial metabolism. Here, we show …

at, fr, us (code pays fourni par la source)

Crosstalk between CD8+ T cells and systemic bile acid metabolism shapes antiviral immunity and immunopathology

Felix Clemens Richter, Zsofia Keszei, Csilla Viczenczová, Maximilian Baumgartner et autres

Antiviral immunity profoundly impacts host metabolism, which can, in turn, modulate immune responses and influence disease pathology. The liver orchestrates systemic bile acid (BA) metabolism, a pathway disrupted in chronic liver diseases such as viral hepatitis. BAs are increasingly recognized for their …

at, de, es, se (code pays fourni par la source)

Tyrosine kinase targeting uncovers oncogenic pathway plasticity in Tasmanian devil transmissible cancers

Anna Schönbichler, Anna Orlova, Carmen Kreindl, Lukas Endler et autres

Two transmissible cancers, Devil Facial Tumour 1 (DFT1) and Devil Facial Tumour 2 (DFT2), have caused a significant decline in the Tasmanian devil population. DFT1 is driven by ERBB, while DFT2 is driven by PDGFRA. We show that DFT cancer cells exhibit …

at, au, ca (code pays fourni par la source)

Genomic surveillance of SARS-CoV-2 evolution by a centralised pipeline and weekly focused sequencing, Austria, January 2021 to March 2023

Olga Frank, David Acitores Balboa, Maria Novatchkova, Ezgi Özkan et autres

BackgroundThe COVID-19 pandemic was largely driven by genetic mutations of SARS-CoV-2, leading in some instances to enhanced infectiousness of the virus or its capacity to evade the host immune system. To closely monitor SARS-CoV-2 evolution and resulting variants at genomic-level, an innovative …

at, us (code pays fourni par la source)

Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny

Martin Hunt, Angie S. Hinrichs, D.P. Anderson, Lily Karim et autres

The SARS-CoV-2 genome occupies a unique place in infection biology - it is the most highly sequenced genome on earth (making up over 20% of public sequencing datasets) with fine scale information on sampling date and geography, and has been subject to …

gb, us, at, Ghana, ar, it, sg, th, nl, de, fr, Afrique du Sud, fi, lk, in, pl, Zimbabwe, cr, Malawi, Éthiopie, Burundi, Niger (code pays fourni par la source)

Detection and abundance of SARS-CoV-2 in wastewater in Liechtenstein, and the estimation of prevalence and impact of the B.1.1.7 variant

Rudolf Markt, Lukas Endler, Fabian Amman, Anna Schedl et autres

The COVID-19 pandemic demonstrated the necessity for highly interdisciplinary, multi-stakeholder collaboration to enable effective public health practice and response. The application of wastewater monitoring to support the pandemic response was demonstrated quickly, leveraging existing scientific and engineering capability to develop rapidly methods …

WAVES (Web-based tool for Analysis and Visualization of Environmental Samples)—a web application for visualization of wastewater pathogen sequencing results

Petr Tříska, Fabian Amman, Lukas Endler, Andreas Bergthaler

MOTIVATION: Environmental monitoring of pathogens provides an accurate and timely source of information for public health authorities and policymakers. In the last 2 years, wastewater sequencing proved to be an effective way of detection and quantification of severe acute respiratory syndrome coronavirus …

at (code pays fourni par la source)

Viral variant-resolved wastewater surveillance of SARS-CoV-2 at national scale

Fabian Amman, Rudolf Markt, Lukas Endler, Sebastian Hupfauf et autres

at (code pays fourni par la source)

WAVES (Web-based tool for Analysis and Visualization of Environmental Samples) – a web application for visualization of wastewater pathogen sequencing results

Petr Tříska, Fabian Amman, Lukas Endler, Andreas Bergthaler

Summary Environmental monitoring of pathogens provides an accurate and timely source of information for public health authorities and policymakers. In the last two years, wastewater sequencing proved to be an effective way of detection and quantification of SARS-CoV-2 variants circulating in population. …

at (code pays fourni par la source)

Emergence of SARS-CoV-2 Alpha lineage and its correlation with quantitative wastewater-based epidemiology data

Elena Radu, Fabian Amman, Anna Schedl, Benedikt Agerer et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gave rise to an international public health emergency in 3 months after its emergence in Wuhan, China. Typically for an RNA virus, random mutations occur constantly leading to new lineages, incidental with a higher transmissibility. …

at, ro (code pays fourni par la source)

National-scale surveillance of emerging SARS-CoV-2 variants in wastewater

Fabian Amman, Rudolf Markt, Lukas Endler, Sebastian Hupfauf et autres

Abstract SARS-CoV-2 surveillance is crucial to identify variants with altered epidemiological properties. Wastewater-based epidemiology (WBE) provides an unbiased and complementary approach to sequencing individual cases. Yet, national WBE surveillance programs have not been widely implemented and data analyses remain challenging. We deep-sequenced …

at (code pays fourni par la source)

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

Riem Gawish, Philipp Starkl, Lisabeth Pimenov, Anastasiya Hladik et autres

Despite tremendous progress in the understanding of COVID-19, mechanistic insight into immunological, disease-driving factors remains limited. We generated maVie16, a mouse-adapted SARS-CoV-2, by serial passaging of a human isolate. In silico modeling revealed how only three Spike mutations of maVie16 enhanced interaction …

at, us, es, se, nl, ca (code pays fourni par la source)