Anuradha Balasubramanian

Bioengineered Nanoparticles: Bacterial Surfactant-assisted Synthesis of Silver Nanoparticles and their Multifunctional Applications

Jameer Ahamed. S, A. S, Anuradha Balasubramanian, Chunmeng Shi et autres

Biosurfactants are surface-active agents synthesized by microorganisms, containing hydrophilic and hydrophobic domains. They lower surface tension at air/water interfaces and are primarily composed of polymeric heterosaccharide proteins. Nanotechnology manipulates nanoparticles, which have unique properties and biochemical and catalytic activity. Silver nanoparticles (AgNP) …

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Jack bean urease

Anuradha Balasubramanian, Karthe Ponnuraj

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List of contributors

Anuradha Balasubramanian, Stefano Benini, Alfred Botha, Célia R. Carlini et autres

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Correction: Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes

Nagaraja Tirumuru, Li Chen, Anuradha Balasubramanian, Jerome E. Groopman et autres

There is an error in Fig 3A, where the GAPDH results of Figs 1C and 2D were inadvertently included in Fig 3A during figure preparation.The updated Fig 3 provided with this notice shows the correct Fig 3A.The authors explain that the Figs …

Functional Heterogeneity of Neutrophils in the Lungs During Infection

Laxman Ghimire, J. Li, Xuemei Xie, Alan Y. Hsu et autres

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Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors

Rachel P. M. Abrams, Adam Yasgar, T Teramoto, Myoung‐Hwa Lee et autres

When Zika virus emerged as a public health emergency there were no drugs or vaccines approved for its prevention or treatment. We used a high-throughput screen for Zika virus protease inhibitors to identify several inhibitors of Zika virus infection. We expressed the …

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Hsp90 of E. coli modulates assembly of FtsZ, the bacterial tubulin homolog

Anuradha Balasubramanian, Monica Markovski, Joel R. Hoskins, Shannon M. Doyle et autres

Significance Hsp90 is a molecular chaperone that participates in protein remodeling and activation. We previously demonstrated that Hsp90 causes cell filamentation when highly expressed in E. coli . Here we show that cells filament due to overexpression of Hsp90 Ec because FtsZ, …

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Selecting an Optimal Positive IHC Control for Verifying Antigen Retrieval

Seshi R. Sompuram, Kodela Vani, Anika K. Schaedle, Anuradha Balasubramanian et autres

Positive immunohistochemistry (IHC) controls are intended to detect problems in both immunostaining and heat-induced epitope retrieval (HIER). However, it is not known what features in a control are important for verifying HIER. Contrary to expectation, the fact that a tissue is formalin-fixed …

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Inhibition of dengue virus by curcuminoids

Anuradha Balasubramanian, Rajendra Pilankatta, T Teramoto, Ayyiliath M. Sajith et autres

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Quantitative Assessment of Immunohistochemistry Laboratory Performance by Measuring Analytic Response Curves and Limits of Detection

Seshi R. Sompuram, Kodela Vani, Anika K. Schaedle, Anuradha Balasubramanian et autres

CONTEXT: - Numerous studies highlight interlaboratory performance variability in diagnostic immunohistochemistry (IHC) testing. Despite substantial improvements over the years, the inability to quantitatively and objectively assess immunostain sensitivity complicates interlaboratory standardization. OBJECTIVE: - To quantitatively and objectively assess the sensitivity of the …

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The Importance of Epitope Density in Selecting a Sensitive Positive IHC Control

Kodela Vani, Seshi R. Sompuram, Anika K. Schaedle, Anuradha Balasubramanian et autres

Clinical Immunohistochemistry (IHC) laboratories face unique challenges in performing accurate and reproducible immunostains. Among these challenges is the use of homemade controls derived from pathological discard samples. Such positive controls have an unknown number of analyte molecules per cell (epitope density). It …

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Serotype-specific interactions among functional domains of dengue virus 2 nonstructural proteins (NS) 5 and NS3 are crucial for viral RNA replication

T Teramoto, Anuradha Balasubramanian, Kyung H. Choi, Radhakrishnan Padmanabhan

Four serotypes of mosquito-borne dengue virus (DENV), evolved from a common ancestor, are human pathogens of global significance for which there is no vaccine or antiviral drug available. The N-terminal domain of DENV NS5 has guanylyltransferase and methyltransferase (MTase), and the C-terminal …

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