Elena Murcia García

An Integrated Computational–Experimental Strategy For the Prediction of Small Molecules as GLP-1R Agonists

Elena Murcia García, Ning Tian, Jorge Ricardo Alonso Fernández, Xiaoqing Cai et autres

Abstract The glucagon-like peptide-1 receptor (GLP-1R) plays a central role in metabolic regulation and is a major therapeutic target for obesity and diabetes. Peptide agonists, like semaglutide, targeting the GLP-1R remain among the most effective regulators of glucose metabolism and appetite. Nonetheless, …

es, cn (code pays fourni par la source)

A MULTI-DIMENSIONAL MACHINE LEARNING APPROACH FOR CARDIOVASCULAR DISEASE PREDICTION IN THE UK BIOBANK STUDY

Juan José Hernández Morante, Elena Murcia García, Carlos Martínez-Cortés, Carmen Piernas et autres

Abstract Cardiovascular diseases (CVD) are complex disorders involving the impaired function of blood vessels or the heart. Several risk factors contribute to CVD, including diet, body composition and physical activity. We developed an interpretable machine learning model integrating nongenetic factors from 502,134 …

es (code pays fourni par la source)

OBE-DB: A Computational Tool and Web Server for the Prediction of Antiobesity Drugs

Elena Murcia García, Carlos Martínez-Cortés, Antonio Jesús Banegas‐Luna, Juan José Hernández Morante et autres

ABSTRACT The huge obesity prevalence and its associated metabolic disorders highlight the urgent need for new therapeutic strategies beyond lifestyle interventions. Despite the availability of novel pharmacological treatments, the search for more effective and safe anti-obesity compounds remains a challenge. Recent advances …

es (code pays fourni par la source)

Effect of Silibinin on Human Pancreatic Lipase Inhibition and Gut Microbiota in Healthy Volunteers: A Randomized Controlled Trial

Elena Murcia García, Horacio Pérez‐Sánchez, Fermı́n I. Milagro, José Ignacio Riezu‐Boj et autres

Thistle (Onopordum acanthium) has been traditionally employed for liver protection. However, we recently identified silibinin, the main bioactive compound of thistle extract, as an in vitro pancreatic lipase inhibitor, which suggested a potential role as an anti-obesity agent. This study aimed to …

es (code pays fourni par la source)

Effect of Silibinin on Human Pancreatic Lipase Inhibition and Gut Microbiota in Healthy Volunteers: A Randomized Controlled Trial

Elena Murcia García, Horacio Pérez‐Sánchez, Fermı́n I. Milagro, José Ignacio Riezu‐Boj et autres

Thistle (Onopordum acanthium) has been traditionally employed for liver protection, however, we recently identified silibinin, the main bioactive compound of thistle extract, as an in vitro pancreatic lipase inhibitor, which suggested a potential role as anti-obesity agent. This study aimed to assess, …

Effects on the balance of fatty acids and lipid metabolism.

Pere Duran Montgé, Elena Murcia García

Effect of dietary fat on gene expression related with pig lipid metabolism

Elena Murcia García, Peter Kappel Theil, Charlotte Lauridsen

Direct effect of cannabinoids and ghrelin on liver and adipose cell metabolism via the AMP-activated protein kinase (AMPK) enzyme

Paolo Dalino Ciaramella, David Aguilar, A Isidori, Erika Hubina et autres

Dietary trans fatty acids affect tissue composition and function in early life.

Elvira Larqué, Elena Murcia García, Francisca Pérez‐Llamas, Salvador Zamora et autres