Sophia Chia‐Ning Chang

189. Risk Factors for the Progression from Clostridioides difficile Colonization to Infection: A Single-Center, Retrospective Case-Control Study

Sophia Chia‐Ning Chang, Deverick John Anderson, Michael Edwards Yarrington, Nicholas Turner

Abstract Background Clostridioides difficile infection (CDI) remains the leading cause of healthcare–associated infection. Patients colonized with toxigenic C. difficile are at an increased risk of developing CDI. Data remains limited on the distinct host and clinical characteristics that impact this risk of …

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Risk factors for progression from Clostridioides difficile colonization (NAAT+/toxin–) to infection (toxin+) following symptomatic retesting

Sophia Chia‐Ning Chang, Nicholas Turner, Michael Edwards Yarrington, Deverick John Anderson

Abstract Objective: To identify host and clinical risk factors contributing to the development of Clostridioides difficile infection (CDI) among colonized patients. Design: Retrospective, matched case-control study. Setting: Duke University Health System, including 3 hospitals and affiliated outpatient clinics. Participants: Adult patients who …

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Immediate Reconstruction With Autologous Temporoparietal Fascia After Enucleation of Infected or Extruded Alloplastic Nasal Implants

Peng Xiao, Sophia Chia‐Ning Chang

Simultaneous reconstruction after removal of nasal silicone implants was published as diced, autologous rib and ear auricular cartilages, and each had their shortcomings. Temporoparietal fascial grafts were used for facial and nasal contouring, vascularized tissue coverage, and augmentation the nose, lip. The …

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Supplementary Figures Legends 1-8 from Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

Younghoon Kee, Min Huang, Sophia Chia‐Ning Chang, Lisa A. Moreau et autres

PDF file - 51K

Supplementary Figure 8 from Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

Younghoon Kee, Min Li HUANG, Sophia Chia‐Ning Chang, Lisa A. Moreau et autres

PDF file - 288K

Supplementary Figures 1-7 from Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

Younghoon Kee, Min Huang, Sophia Chia‐Ning Chang, Lisa A. Moreau et autres

PDF file - 581K

Supplementary Figures 1-7 from Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

Younghoon Kee, Min Huang, Sophia Chia‐Ning Chang, Lisa A. Moreau et autres

PDF file - 581K

Supplementary Figures Legends 1-8 from Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

Younghoon Kee, Min Huang, Sophia Chia‐Ning Chang, Lisa A. Moreau et autres

PDF file - 51K

Supplementary Figure 8 from Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

Younghoon Kee, Min Li HUANG, Sophia Chia‐Ning Chang, Lisa A. Moreau et autres

PDF file - 288K

Data from Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

Younghoon Kee, Min Li HUANG, Sophia Chia‐Ning Chang, Lisa A. Moreau et autres

Abstract The Fanconi anemia pathway is required for repair of DNA interstrand cross-links (ICL). Fanconi anemia pathway–deficient cells are hypersensitive to DNA ICL–inducing drugs such as cisplatin. Conversely, hyperactivation of the Fanconi anemia pathway is a mechanism that may underlie cellular resistance …

Data from Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents

Younghoon Kee, Min Huang, Sophia Chia‐Ning Chang, Lisa A. Moreau et autres

Abstract The Fanconi anemia pathway is required for repair of DNA interstrand cross-links (ICL). Fanconi anemia pathway–deficient cells are hypersensitive to DNA ICL–inducing drugs such as cisplatin. Conversely, hyperactivation of the Fanconi anemia pathway is a mechanism that may underlie cellular resistance …

Efficient endothelial and smooth muscle cell differentiation from human pluripotent stem cells through a simplified insulin-free culture system

Fengzhi Zhang, Yonglin Zhu, Jing Chen, Wenhua Kuang et autres

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