Ursula Reinhard

Association of IgG N-Glycans With Adverse Outcomes in CKD

Elena Butz, Miriam I.J. Bach, Fruzsina Kotsis, Inga Steinbrenner et autres

Introduction: IgG N-glycosylation modulates inflammation and may influence chronic kidney disease (CKD). We investigated associations between IgG N-glycan patterns, kidney function, mortality, and kidney failure (KF) within the German CKD (GCKD) study. Methods: or overt albuminuria). We assessed associations with baseline kidney …

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Long-term outcomes of patients with IgA nephropathy in the German CKD cohort

Eleni Stamellou, Jennifer Nadal, Bruce M. Hendry, Alex Mercer et autres

Background: The importance of albuminuria as opposed to proteinuria in predicting kidney outcomes in primary immunoglobulin A nephropathy (IgAN) is not well established. Methods: and initiation of kidney replacement therapy; the individual components of the CKE; and combined major adverse cardiac events …

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Long-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort

Eleni Stamellou, Jennifer Nadal, Bruce M. Hendry, Alex Mercer et autres

ABSTRACT Background Focal segmental glomerulosclerosis (FSGS) can lead to kidney failure in adults. This study examines the progression of FSGS in the German Chronic Kidney Disease (GCKD) cohort. Methods The GCKD study (N = 5217), a prospective cohort, included 159 patients with …

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Interactive exploration of adverse events and multimorbidity in CKD

Inga Steinbrenner, Fruzsina Kotsis, Robin Kosch, Heike Meiselbach et autres

BACKGROUND: Persons with chronic kidney disease (CKD) are at increased risk of adverse events, early mortality and multimorbidity. A detailed overview of adverse event types and rates from a large CKD cohort under regular nephrological care is missing. We generated an interactive …

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Apolipoprotein A-IV concentrations and cancer in a large cohort of chronic kidney disease patients: results from the GCKD study

Barbara Kollerits, Simon Gruber, Inga Steinbrenner, Johannes P. Schwaiger et autres

Abstract Background Chronic kidney disease (CKD) is highly connected to inflammation and oxidative stress. Both favour the development of cancer in CKD patients. Serum apolipoprotein A-IV (apoA-IV) concentrations are influenced by kidney function and are an early marker of kidney impairment. Besides …

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Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease (GCKD) cohort

Katharina C. Reimer, Jennifer Nadal, Heike Meiselbach, Matthias Schmid et autres

Abstract Mineral and bone disorder (MBD) in chronic kidney disease (CKD) is tightly linked to cardiovascular disease (CVD). In this study, we aimed to compare the prognostic value of nine MBD biomarkers to determine those associated best with adverse cardiovascular (CV) outcomes …

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Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Markus P. Schneider, Matthias Schmid, Jennifer Nadal, Vera Krane et autres

Rationale & Objective: Copeptin and Midrange pro-atrial natriuretic peptide (MR-pro-ANP) are associated with outcomes independently of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) in patients with heart failure (HF). The value of these markers in patients with chronic kidney disease (CKD) has not been …

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Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Claudia Sommerer, Sandra Müller-Krebs, Jennifer Nadal, Ulla T. Schultheiß et autres

Introduction Soluble urokinase plasminogen activation receptor (suPAR) is an immune-derived pathogenic factor for kidney and atherosclerotic disease. Whether the association between suPAR and cardiovascular (CV) outcomes is dependent on the severity of underlying kidney disease is unclear. Methods We measured serum suPAR …

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Differential Prognostic Utility of Adiposity Measures in Chronic Kidney Disease

Vladimir Cejka, Stefan Störk, Jennifer Nadal, Matthias Schmid et autres

OBJECTIVE: Adipose tissue contributes to adverse outcomes in chronic kidney disease (CKD), but there is uncertainty regarding the prognostic relevance of different adiposity measures. We analyzed the associations of neck circumference (NC), waist circumference (WC), and body mass index (BMI) with clinical …

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Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study

Helena Bächle, Peggy Sekula, Pascal Schlosser, Inga Steinbrenner et autres

BACKGROUND: The progression of chronic kidney disease (CKD), a global public health burden, is accompanied by a declining number of functional nephrons. Estimation of remaining nephron mass may improve assessment of CKD progression. Uromodulin has been suggested as a marker of tubular …

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Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study

Inga Steinbrenner, Peggy Sekula, Fruzsina Kotsis, Maja von Cube et autres

BACKGROUND: Osteopontin (OPN), synthesized in the thick ascending limb of Henle's loop and in the distal tubule, is involved in the pathogenesis of kidney fibrosis, a hallmark of kidney failure (KF). In a cohort of chronic kidney disease (CKD) patients, we evaluated …

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Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study

Markus P. Schneider, Matthias Schmid, Jennifer Nadal, Christoph Wanner et autres

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