Accès ouvert
2026
article
OpenAlex
Katharina Daniel, Leon Ullrich, Denis Ruchnewitz, Matthijs Meijers et autres
The transmission of influenza A virus H5N1 clade 2.3.4.4b from cattle to humans highlights the risk of an H5N1 pandemic. Pre-existing immunity strongly impacts the course and severity of viral infections, making detailed knowledge of antibodies against the spilled-over strain crucial. Here, …
de
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Katharina Daniel, Leon Ullrich, Denis Ruchnewitz, Matthijs Meijers et autres
Abstract The spill-over of Influenza A virus H5N1 clade 2.3.4.4b from cattle to humans highlights the risk of a human H5N1 pandemic. Given the impact of pre-existing immunity on the course and severity of viral infections, we comprehensively assessed the humoral immunity …
de
(code pays fourni par la source)
2025
book-chapter
OpenAlex
Matthijs Meijers, Denis Ruchnewitz, Jan Eberhardt, Malancha Karmakar et autres
de, us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Matthijs Meijers, Denis Ruchnewitz, Jan Eberhardt, Malancha Karmakar et autres
The seasonal human influenza virus undergoes rapid evolution, leading to significant changes in circulating viral strains from year to year. These changes are typically driven by adaptive mutations, particularly in the antigenic epitopes, the regions of the viral surface protein haemagglutinin targeted …
de, us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Matthijs Meijers, Denis Ruchnewitz, Jan Eberhardt, Malancha Karmakar et autres
The seasonal human influenza virus undergoes rapid evolution, leading to significant changes in circulating viral strains from year to year. These changes are typically driven by adaptive mutations, particularly in the antigenic epitopes, the regions of the viral surface protein haemagglutinin targeted …
Accès ouvert
2023
article
OpenAlex
Matthijs Meijers, Denis Ruchnewitz, Jan Eberhardt, Marta Łuksza et autres
The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of genetic clades. New variants show intrinsic changes, notably increased transmissibility, and antigenic changes that reduce cross-immunity induced by previous infections or vaccinations. How this functional variation shapes global …
de, us
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Matthijs Meijers, Denis Ruchnewitz, Marta Łuksza, Michael Lässig
Abstract The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of genetic clades. New variants show intrinsic changes, notably increased transmissibility, as well as anti-genic changes that reduce the cross-immunity induced by previous infections or vaccinations 1–4 . …
de, us
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Matthijs Meijers, Denis Ruchnewitz, Marta Łuksza, Michael Lässig
The large-scale evolution of the SARS-CoV-2 virus has been marked by rapid turnover of genetic clades. New variants show intrinsic changes, notably increased transmissibility, as well as antigenic changes that reduce the cross-immunity induced by previous infections or vaccinations. How this functional …
Accès ouvert
2021
article
OpenAlex
Kanika Vanshylla, Chengcheng Fan, Marie Wunsch, Nareshkumar Poopalasingam et autres
de, us, cn
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Matthijs Meijers, Kanika Vanshylla, Henning Gruell, Florian Klein et autres
Broadly neutralizing antibodies are promising candidates for treatment and prevention of HIV-1 infections. Such antibodies can temporarily suppress viral load in infected individuals; however, the virus often rebounds by escape mutants that have evolved resistance. In this paper, we map a fitness …
de
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Matthijs Meijers, Sosuke Ito, Pieter Rein ten Wolde
Recent experiments have indicated that many biological systems self-organize near their critical point, which hints at a common design principle. While it has been suggested that information transmission is optimized near the critical point, it remains unclear how information transmission depends on …
nl, jp
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Matthijs Meijers, Kanika Vanshylla, Henning Gruell, Florian Klein et autres
ABSTRACT Broadly neutralizing antibodies are promising candidates for treatment and prevention of HIV-1 infections. Such antibodies can temporarily suppress viral load in infected individuals; however, the virus often rebounds by escape mutants that have evolved resistance. In this paper, we map an …
de
(code pays fourni par la source)