Accès ouvert
2023
article
OpenAlex
Chie Hashikawa‐Muto, Yoshiro Yokoyama, Ryo Hamamoto, Kazuya Kobayashi et autres
Virus filtration is one of the most important steps in ensuring viral safety during the purification of monoclonal antibodies (mAbs) and other biotherapeutics derived from mammalian cell cultures. Regarding the various virus retentive filters, including Planova filters, a great deal of data …
jp, de
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Accès ouvert
2020
article
OpenAlex
Teruya Nakamura, Chie Hashikawa‐Muto, Kohtaro Okabe, Yuya Yokote et autres
TRAF-interacting protein with a forkhead-associated (FHA) domain (TIFA), originally identified as an adaptor protein of TRAF6, has recently been shown to be involved in innate immunity, induced by a pathogen-associated molecular pattern (PAMP). ADP-β-D-manno-heptose, a newly identified PAMP, binds to alpha-kinase 1 …
jp
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2019
article
OpenAlex
Yumiko Masuda, Masashi Tsuda, Chie Hashikawa‐Muto, Yusuke Takahashi et autres
Viral safety is a critical concern with regard to monoclonal antibody (mAb) products produced in mammalian cells such as Chinese hamster ovary cells. Manufacturers are required to ensure the safety of such products by validating the clearance of viruses in downstream purification …
jp
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Accès ouvert
2012
article
OpenAlex
Y. Koga, Miyuki Inazato, Teruya Nakamura, Chie Hashikawa‐Muto et autres
Human MTH1 (hMTH1) is an enzyme that hydrolyses several oxidized purine nucleoside triphosphates to their corresponding nucleoside monophosphates. Crystallographic studies have shown that the accurate mode of interaction between 8-oxoguanine and hMTH1 cannot be understood without determining the positions of the H …
jp
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Accès ouvert
2011
article
OpenAlex
Y. Yamagata, Yuichi Koga, Chie Hashikawa‐Muto, Miyuki Inazato et autres
unexpected structural change presented here provides a cautionary note about interpreting functional data derived from a mutated protein in the absence of its exact structure.
jp
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