Koushik Chakrabarty

Sesamol reprograms mitochondrial dysfunction and metabolic signaling to rescue endothelial degeneration in Fuchs’ endothelial corneal dystrophy

Divyani Nayak, Ramaraj Kannan, Sharon D'Souza, Shivapriya Shivakumar et autres

in (code pays fourni par la source)

Trehalose extricates impaired mitochondrial and autophagy dysregulation in patient iPSC-derived macular corneal dystrophy disease model

Divyani Nayak, Shivapriya Shivakumar, Rohit Shetty, K. N. Prashanthi et autres

BACKGROUND: Patient-derived induced pluripotent stem cell (iPSCs) represents a powerful tool for elucidating the underlying disease mechanisms. Macular corneal dystrophy (MCD) is an intractable and progressive bilateral corneal disease affecting the corneal stroma due to mutation/s in carbohydrate sulfotransferase 6 (CHST6) gene. …

in (code pays fourni par la source)

Exploring The Therapeutic Potential: In-Vitro Assessment of Antioxidant and Anti-Inflammatory Activity Of methanolic extract from Tabernaemontana divaricata Leaves

Somnath Mondal, Koushik Chakrabarty, Mayukh Bose, Sudip Maity et autres

Introduction: Medicinal plants have various applications in the field of medical sciences. Plants are wide source of numerous phyto-constituents which have been proved to have multiple health benefits. Literature says that leaves of Tabernaemontana divaricata are loaded with such phyto-chemicals which can …

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Retinal organoids in disease modeling and drug discovery: Opportunities and challenges

Koushik Chakrabarty, Divyani Nayak, Jayasree Debnath, Debashish Das et autres

in (code pays fourni par la source)

Generation of iPSC line (GLNNFi001-A) from peripheral blood mononuclear cells of a patient with macular corneal dystrophy

Koushik Chakrabarty, K. N. Prashanthi, Rohit Shetty, Shubham Argulwar et autres

Macular corneal dystrophy (MCD) an autosomal recessive disorder leading to severe visual impairment is caused by mutations in the carbohydrate sulfotransferase 6 (CHST6) gene. Here, we describe generation of a iPSC line from peripheral blood mononuclear cells (PBMCs) from a 38 year …

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Induced pluripotent stem cell-based disease modeling and prospective immune therapy for coronavirus disease 2019

Koushik Chakrabarty, Rohit Shetty, Shubham Argulwar, Debashish Das et autres

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Tear Fluid Angiogenic Factors: Potential Noninvasive Biomarkers for Retinopathy of Prematurity Screening in Preterm Infants

Anand Vinekar, Archana Padmanabhan Nair, Shivani Sinha, Tanuja Vaidya et autres

Purpose: To determine the status of proangiogenic factors in the tear fluid of preterm infants with and without retinopathy of prematurity (ROP). Methods: Preterm infants (n = 36) undergoing routine ROP screening included in the prospective study were categorized as No-ROP (n …

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Stem cell therapy in coronavirus disease 2019: current evidence and future potential

Rohit Shetty, Ponnalagu Murugeswari, Koushik Chakrabarty, Chaitra Jayadev et autres

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Modeling macular corneal dystrophy using corneal organoids from patient derived induced pluripotent stem cells

Koushik Chakrabarty, Karthikeyan Ramaswamy, Praveen Machiraju, Shubham Argulwar et autres

in (code pays fourni par la source)

Distinct ocular surface soluble factor profile in human corneal dystrophies

Rohit Shetty, Jagadeesh R. Naidu, Archana Padmanabhan Nair, Tanuja Vaidya et autres

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Corneal cell therapy: with iPSCs, it is no more a far-sight

Koushik Chakrabarty, Rohit Shetty, Arkasubhra Ghosh

Human-induced pluripotent stem cells (hiPSCs) provide a personalized approach to study conditions and diseases including those of the eye that lack appropriate animal models to facilitate the development of novel therapeutics. Corneal disease is one of the most common causes of blindness. …

in (code pays fourni par la source)

Dyskinesia in Parkinson's disease: mechanisms and current non‐pharmacological interventions

Rolf Heumann, Rosario Moratalla, María Trinidad Herrero, Koushik Chakrabarty et autres

Dopamine replacement therapy in Parkinson's disease is associated with several unwanted effects, of which dyskinesia is the most disabling. The development of new therapeutic interventions to reduce the impact of dyskinesia in Parkinson's disease is therefore a priority need. This review summarizes …

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