Claudia Leoni

Digital Droplet PCR (ddPCR) for Absolute Quantification of 16S rRNA Copy Number in Metagenomic Data

Claudia Leoni, Marinella Marzano, Ermes Filomena, Anna Maria D’Erchia

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Lanthanum exposure and its metabolomic effects on Ruditapes philippinarum

Fabrizio Mastrorocco, Marco Vito Guglielmi, Luca De Martino, Clara Musicco et autres

The growing release of rare earth elements (REEs) into aquatic environments, driven by their extensive industrial and technological applications, has raised growing concern due to their largely unknown ecological and toxicological effects. Among these, lanthanum (La), one of the most widely used …

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Dissecting B Cell Landscape and Receptor Repertoire in Plasma Cell Neoplasms at Single Cell Resolution

Filippo Viviani, Francesca Lazzaroni, Emanuele Calvi, Antonio Matera et autres

Impact of Control-Plane Uplink in Asymmetric RF/RIS-Aided VLC Indoor System

Claudia Leoni, Anna Maria Vegni

Apart the well-known benefits of Visible Light Commmunications (VLC), some drawbacks still limit its realworld deployment and market penetration, such as the need of link alignment, shadowing, and blockage. Radio Frequency (RF) technology is traditionally adopted to alleviate such limitations, acting as …

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Real‐world evidence of pegcetacoplan in patients with paroxysmal nocturnal haemoglobinuria: A nationwide Italian study

Elisabetta Metafuni, Filippo Achille Brioschi, Andrea Patriarca, Claudia Leoni et autres

In this study, we collected real-world evidence on the use of pegcetacoplan among 22 Italian patients with paroxysmal nocturnal haemoglobinuria showing suboptimal response to anti-C5 treatments eculizumab and ravulizumab. Most patients exhibited a complete or good response as per the criteria of …

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Rapid and Ultra‐Sensitive SARS‐CoV‐2 Subgenomic RNA Detection Using Single‐Molecule With a Large Transistor‐SiMoT Bioelectronic Platform

Eleonora Macchia, Anna Maria D’Erchia, Mariapia Caputo, Angelica Bianco et autres

Abstract The replication of Coronaviridae viruses depends on the synthesis of structural proteins expressed through the discontinuous transcription of subgenomic RNAs (sgRNAs). Thus, detecting sgRNAs, which reflect active viral replication, provides valuable insights into infection status. Current diagnostic methods, such as PCR‐based …

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Intrinsic and Microenvironmental Determinants of AML Response to HMA-Venetoclax Therapy at the Single-Cell Transcriptomic Level

Alfredo Marchetti, Francesca Lazzaroni, Matteo Da Vià, Alessio Marella et autres

The combination of hypomethylating agents (HMA) with Venetoclax has become standard of care in patients with Acute Myeloid Leukemia (AML) unfit for intensive chemotherapy. Genetic and cellular resistance mechanisms, such as RAS and TP53 mutations as well as monocytic differentiation, were recently …

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Evaluating Lanthanum-Induced Alterations in Manila Clam: An Integrated Method

Marco Vito Guglielmi, Michela Marashi, Daniela Semeraro, Marcella Narracci et autres

Lanthanum (La), a rare earth element, has unique properties that make it valuable in various industries. Extraction activities pose environmental and health risks due to pollution, habitat disruption, and human exposure to hazardous chemicals. Animal models are needed to evaluate La effects …

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Reputation-based Trustworthiness Degree in Interference-variable Vehicular Networks

Claudia Leoni, Anna Maria Vegni, Valéria Loscrì, Abderrahim Benslimane

Trustworthiness in wireless networks is an open challenge due to several features that should be taken into account. All the networking concepts should be updated accordingly, as well as physical layer features that influence the node transmission ability. Indeed, a trusted vehicle …

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Endometrial Cancer: A Pilot Study of the Tissue Microbiota

Claudia Leoni, Lorenzo Vinci, Marinella Marzano, Anna Maria D’Erchia et autres

BACKGROUND: The endometrium remains a difficult tissue for the analysis of microbiota, mainly due to the low bacterial presence and the sampling procedures. Among its pathologies, endometrial cancer has not yet been completely investigated for its relationship with microbiota composition. In this …

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A Reputation-Based Trustworthiness Concept for Wireless Networking in Vehicular Social Networks

Anna Maria Vegni, Claudia Leoni, Valéria Loscrì, Abderrahim Benslimane

Social features are affecting different application areas, from traditional online social networks to economical networks, as well as the study of epidemical behaviors of pandemics and diseases. From the information point of view also, the Internet paradigm has been revised according to …

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Evaluation of Couples at Risk for Hemoglobin Disorders in Italy: The Results of an 18-Month Retrospective Observational Single-Center Study

Alfredo Marchetti, Elisa Sambruna, Giacomo Aquilino, Francesco Ballardini et autres

Background: Hemoglobinopathies are genetic disorders caused by mutations in the genes encoding globin chains. These conditions are the most common monogenic disorders worldwide, resulting in significant morbidity and mortality among those affected by the most severe forms. Antenatal evaluation for thalassemia and …

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