Sha Yang

Theaflavin attenuates atherosclerosis by targeting GSK-3β to suppress pyroptosis and Promote Autophagy in macrophages

Sha Yang, Li Liao, Qin Yang, Tianqin Xia et autres

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Alantolactone Inhibits Double Expression Lymphoma via Dual-Targeted Glycogen Synthase Kinase 3 Beta and B-Cell Lymphoma2

Jianhua Chen, Qing Kui Liao, Sha Yang, Jiaojiao Bian et autres

Background: Dual-expression lymphoma (DEL) is an aggressive subtype with concurrent MYC and BCL2 overexpression. This disease exhibits a poor prognosis and responds poorly to standard R-CHOP therapy,highlighting the urgent need for novel treatments. Alantolactone (ALA), a natural compound, has shown anticancer potential, …

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Development and Validation of a Nomogram for Early Prediction of Heat Stroke Induced Cardiorenal Syndrome: A Multicenter Retrospective Cohort Study

Tao Cheng, Guo Tang, Tian-Shan Zhang, Ping Zhang et autres

Background Heat stroke (HS) is a life‐threatening condition, and its prognosis is severely compromised when accompanied by cardiorenal syndrome (CRS). Early identification of HS‐induced CRS is essential for enhancing clinical outcomes. Objective To develop and validate a nomogram for early prediction of …

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Association of CT-derived extracellular volume fraction combined with serological markers with histological grading of colorectal cancer

Hongli Zhou, Yuan Feng, Sha Yang, Wei Li et autres

This study evaluates the association between computed tomography-derived extracellular volume fraction (CT-ECV), serological markers, and histological grading in colorectal cancer, and to assess their diagnostic value in predicting poorly differentiated tumors. This retrospective study included 200 patients with pathologically confirmed primary colorectal …

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Prediction of acute pancreatitis severity using NLR, procalcitonin, and CT severity score: A retrospective study

Hongli Zhou, Xing Li, Sha Yang

This study aims to evaluate the clinical value of the neutrophil-to-lymphocyte ratio (NLR), procalcitonin (PCT), and computed tomography (CT) severity score in predicting the severity of acute pancreatitis (AP). Additionally, we investigate their correlations with clinical, laboratory, and imaging parameters to provide …

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Specific immune landscape of heatstroke distinguished from sepsis and aseptic inflammation

Juan Wu, Zhenzhen Cheng, Sha Yang, Qinjuan Wu et autres

Heatstroke is associated with immune system disturbances, which was similar to sepsis and aseptic inflammation.This study characterized the immune landscape of heatstroke and compared it to sepsis or aseptic inflammation in order to identify heatstroke-specific characteristics.We prospectively recruited 40 patients with heatstroke …

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Coexisting metabolic dysfunction-associated steatotic liver disease exacerbates in-hospital outcomes in patients with heat stroke

Ping Zhang, Guo Tang, Hongguang Gao, Tian-Shan Zhang et autres

Purpose This study aimed to investigate the impact of coexisting metabolic dysfunction-associated steatotic liver disease (MASLD) on in-hospital mortality and organ injury markers in patients with heat stroke (HS). Approach HS patients were retrospectively identified between July 1, 2022 and September 30, …

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Construction and Evaluation of a Predictive Model for Liver Injury Associated with Heatstroke: A Multicenter Retrospective Study

Hongguang Gao, Guo Tang, Sha Yang, Ying Yang et autres

Background. Liver injury related to heatstroke plays a pivotal role in secondary multiorgan damage and is a direct cause of mortality in affected patients of heatstroke. This study was designed to identify independent risk factors associated with liver injury in heatstroke and …

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Comparison of immune cell profiles associated with heatstroke, sepsis, or cardiopulmonary bypass: Study protocol for an exploratory, case-control study trial

Juan Wu, Sha Yang, Tingting Wang, Qinjuan Wu et autres

Introduction: Heatstroke is a life-threatening illness involving extreme hyperthermia and multi-organ failure, and it is associated with high mortality. The immune profiles of heatstroke have not been fully elucidated, and diagnostic and prognostic biomarkers of heatstroke are lacking. This study will analyze …

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Pathophysiological Changes in Rhesus Monkeys with Paraquat-Induced Pulmonary Fibrosis

Mingyang Shao, Sha Yang, Aiyi Zheng, Zhenru Wu et autres

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