Motoyuki Kohjima

THU-188 Age-related clinical features of metabolic dysfunction associated steatotic liver disease in a real-world cohort

Ryotaro Sakamori, Yutaro Abe, Sumiko Yoshida, Atsumasa Komori et autres

SAT-549 Prognostic value of handgrip strength in 1,294 japanese patients with liver cirrhosis: a large-scale multicenter cohort study from the NHO network

Hiroshi Yatsuhashi, Kazumi Yamasaki, Hayato Yamana, Shinobu Imai et autres

WED-644 Impact of sustained virological response on the prognosis of patients with HCV-related cirrhosis: a large-scale multicenter cohort study from the pre-and post-DAA eras

Hiroshi Yatsuhashi, Hayato Yamana, Shinobu Imai, Atsushi Naganuma et autres

The Conjugated Bile Acids Profile Suggests a Novel Liver‐Muscle Axis Associated With Sarcopenia in Chronic Liver Disease

Motoh Iwasa, Akiko E. Eguchi, Motoyuki Kohjima, Teruo Miyazaki et autres

BACKGROUND: Liver-related sarcopenia is a devastating systemic complication of chronic liver disease (CLD) driven by mechanisms extending beyond nutritional deficiency. However, the role of liver-derived humoral factors remains unclear. We utilised a unique cohort of human skeletal muscle biopsies to test the …

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Clinicopathological features of steroid-refractory immune-mediated hepatotoxicity induced by immune checkpoint inhibitors

Tomonobu Hioki, Koji Imoto, Takeshi Goya, Yuki Azuma et autres

BACKGROUND: Mycophenolate mofetil (MMF) is a second-line agent for steroid-refractory immune checkpoint inhibitor-induced immune-mediated hepatotoxicity (IMH). However, the clinicopathologic characteristics and the efficacy and safety of MMF for steroid-refractory IMH are not fully understood. METHODS: This retrospective study enrolled 33 patients with …

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Long non-coding RNA PWRN4 associated with post-SVR hepatocellular carcinoma: a genome-wide association study

Goki Suda, Masaya Sugiyama, Hayato Hikita, Akira Nishio et autres

A subset of patients still develops hepatocellular carcinoma (HCC) even after eradication of the hepatitis-C virus (HCV) by anti-HCV treatment. We conducted a genome-wide association study (GWAS) to identify host genetic factors associated with HCC development following HCV eradication in Japan. In …

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Advances in Systemic Therapy for Hepatocellular Carcinoma and Future Prospects

Rie Sugimoto, Miho Kurokawa, Yuki Tanaka, Takeshi Senju et autres

The focus of treatment of hepatocellular carcinoma (HCC) has shifted significantly from local therapy to systemic drug therapy. Recently, the efficacy of drug therapy for HCC has made rapid progress. We have transitioned from eras of sorafenib monotherapy and sequential therapy with …

jp (code pays fourni par la source)

Five‐Year Effectiveness and Renal Safety Following Switching to Tenofovir Alafenamide in Chronic Hepatitis B Patients With Renal Impairment

Eiichi Ogawa, Motoyuki Kohjima, Toshimasa Koyanagi, Kazufumi Dohmen et autres

BACKGROUND AND AIM: Long-term nucleos(t)ide analog (NUC) therapy is essential for chronic hepatitis B (CHB) management. However, data on long-term outcomes, particularly for patients switching to tenofovir alafenamide (TAF) and patients with chronic kidney disease (CKD), remain limited. This study aimed to …

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Multi-omics analysis of diabetic cardiomyopathy pathogenesis using a type 2 diabetic Zucker diabetic fatty rat model

Kazuhiro Tanabe, Qianqian Zheng, Xuguang Zhang, Naoki Tanaka et autres

Diabetic cardiomyopathy (DCM) is a leading cause of mortality in patients with diabetes, highlighting the need to better understand its mechanisms for effective treatment. The primary pathogenic mechanism of DCM is mitochondrial dysfunction associated with increased oxidative stress; however, the exact reasons …

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Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe et autres

Liver and pancreatic cancers are difficult to detect early, leading to high mortality rates. Blood-based diagnostics present a viable alternative for earlier detection, potentially improving survival rates. The comprehensive serum glycopeptide spectra analysis (CSGSA) method combines enriched glycopeptides (EGPs) with conventional tumor …

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Advances in Systemic Therapy for Hepatocellular Carcinoma and Future Prospects

Rie Sugimoto, Motoyuki Kohjima, Masatake Tanaka

The treatment of hepatocellular carcinoma has shifted significantly from the era of local therapy to the era of drug therapy, partly because of changes in background factors. Drug therapy for hepatocellular carcinoma has made rapid progress in recent years. We have moved …

jp (code pays fourni par la source)

Author response for "Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study"

Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe et autres