The Conjugated Bile Acids Profile Suggests a Novel Liver‐Muscle Axis Associated With Sarcopenia in Chronic Liver Disease
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Le résumé fourni par la source
BACKGROUND: Liver-related sarcopenia is a devastating systemic complication of chronic liver disease (CLD) driven by mechanisms extending beyond nutritional deficiency. However, the role of liver-derived humoral factors remains unclear. We utilised a unique cohort of human skeletal muscle biopsies to test the hypothesis that serum conjugated bile acids (C-BAs) act as key mediators of this liver-muscle cross-talk. METHODS: Serum and rectus abdominis muscle samples were meticulously collected from 36 CLD patients and 6 non-CLD controls during elective surgery. Multifidus-erector spinae and psoas muscle areas were quantified from CT images. Comprehensive correlations were analysed between C-BAs and molecular markers of muscle inflammation and fibre-type composition. These findings were supplemented by in vitro validation using GCDCA treatment of C2C12 myotubes. RESULTS: , p = 0.019). Muscle area loss was strongly correlated with hepatic reserve deterioration (ALBI/ALB) and systemic inflammation (serum IL-6). Crucially, muscle area was negatively correlated with the ratio of tauro-C-BAs (p < 0.05). Muscle biopsies showed a molecular shift: enrichment of the slow-twitch fibre marker myosin-heavy chain 7 (MYH7, type I) and a concomitant reduction of the fast-twitch marker MYH4 (type IIb), alongside signs of local chronic inflammation (p < 0.05). The reduction in MYH4 was correlated with glyco-C-BAs, a finding replicated in GCDCA-treated C2C12 myotubes. CONCLUSIONS: Elevated C-BAs may represent a critical, liver-derived humoral factor associated with the pathological features of liver-related sarcopenia. C-BA-associated muscle mass loss and systemic inflammation are reflected at the molecular level by a shift toward a slow-twitch phenotype, accumulation of macrophages and altered energy metabolism in muscle biopsies. These findings suggest that C-BAs may serve as a potentially actionable therapeutic target for mitigating muscle catabolism and improving clinical outcomes in CLD patients.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Conjugated Bile Acids Profile Suggests a Novel Liver‐Muscle Axis Associated With Sarcopenia in Chronic Liver Disease
- Date Crossref
- 28/03/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Mie University pays non établi dans la noticeUniversité ou école supérieure
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Mie University Hospital pays non établi dans la noticeÉtablissement de santé
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National Kyushu Medical Center pays non établi dans la noticeÉtablissement de santé
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Tokyo Medical University Ibaraki Medical Center pays non établi dans la noticeÉtablissement de santé
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Tohoku University pays non établi dans la noticeUniversité ou école supérieure
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Baker Heart and Diabetes Institute pays non établi dans la noticeOrganisation à but non lucratif
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University of Alberta pays non établi dans la noticeUniversité ou école supérieure
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University of Alberta Hospital pays non établi dans la noticeÉtablissement de santé
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Department of Gastroenterology Murase Hospital Suzuka Japan pays non établi dans la noticeÉtablissement de santé
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Department of Gastroenterology Clinical Research Institute pays non établi dans la noticeStructure de recherche
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Joint Research Center Tokyo Medical University pays non établi dans la noticeUniversité ou école supérieure
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Department of Hepato‐Biliary‐Pancreatic Surgery NHO Kyushu Medical Center Fukuoka Japan pays non établi dans la noticeÉtablissement de santé
Mie University, Mie University Hospital et National Kyushu Medical Center, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.